DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sgl and sqv-4

DIOPT Version :9

Sequence 1:	NP_476980.1	Gene:	sgl / 38760	FlyBaseID:	FBgn0261445	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_505730.1	Gene:	sqv-4 / 179484	WormBaseID:	WBGene00005022	Length:	481	Species:	Caenorhabditis elegans

Alignment Length:	459	Identity:	304/459 - (66%)
Similarity:	370/459 - (80%)	Gaps:	5/459 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KVCCIGAGYVGGPTCAVMALKCPDIVITLVDKSSERIAQWNSDKLPIYEPGLDEVVKKCRNVNLF 66
            ||.|:|||||||||||::|.|||.|.:|:||.::.:||:|||||||||||||||:|...|..|||
Worm    11 KVVCVGAGYVGGPTCAMIAHKCPHITVTVVDMNTAKIAEWNSDKLPIYEPGLDEIVFAARGRNLF 75

  Fly    67 FSTDIETAIKEADLIFISVNTPTKTCGNGKGRAADLKYVESAARMIAEIAQSNKIVVEKSTVPVR 131
            ||:||..||.||||||||||||||..|.|||.|.|||||||.:|.||:.|...|||||||||||:
Worm    76 FSSDIPKAIAEADLIFISVNTPTKMYGRGKGMAPDLKYVESVSRTIAQYAGGPKIVVEKSTVPVK 140

  Fly   132 AAESIMHILRANQK--PGIHYDILSNPEFLAEGTAINDLLNADRVLIGGEETPEGHQAVEKLSWI 194
            |||||..|||..||  ..:.:.:||||||||||||:.||.|.||||||||.:|||.|||.:|..|
Worm   141 AAESIGCILREAQKNNENLKFQVLSNPEFLAEGTAMKDLANPDRVLIGGESSPEGLQAVAELVRI 205

  Fly   195 YEHWIPKQNILTTNTWSSELSKLAANAFLAQRISSINSLSAVCEATGADVSEVARAVGLDSRIGS 259
            ||:|:|:..|:||||||||||||.||||||||||||||:|||||||||::||||.|||.|:||||
Worm   206 YENWVPRNRIITTNTWSSELSKLVANAFLAQRISSINSISAVCEATGAEISEVAHAVGYDTRIGS 270

  Fly   260 KFLQASVGFGGSCFQKDILNLIYICENLNLPEVAAYWQQVIDMNEYQKRRFSQKIIESLFNTVSD 324
            |||||||||||||||||:|:|:|:||:||||:||.|||.||::|.:|:|||:.|||..|||||:|
Worm   271 KFLQASVGFGGSCFQKDVLSLVYLCESLNLPQVADYWQGVININNWQRRRFADKIIAELFNTVTD 335

  Fly   325 KRIAILGFAFKKNTGDTRETAAITVCQTLLEEGAALDIYDPKVEPEQIIDDLTHPSVTESPEKVK 389
            |:|||.|||||||||||||::||.|.:.|:||.|.|.:|||||:..|:::||.  ||| |.:.|:
Worm   336 KKIAIFGFAFKKNTGDTRESSAIHVIKHLMEEHAKLSVYDPKVQKSQMLNDLA--SVT-SAQDVE 397

  Fly   390 KAVQIHSDPYSAVRATHALVICTEWDEFVDLDFKRIYQSMMKPAYIFDGRKILDHERLQQIGFHV 454
            :.:.:.||||:|.|..||:|:.|||||||:|::.:|:..|..||.|||||.|||.:.|::|||..
Worm   398 RLITVESDPYAAARGAHAIVVLTEWDEFVELNYSQIHNDMQHPAAIFDGRLILDQKALREIGFRT 462

  Fly   455 QTIG 458
            ..||
Worm   463 FAIG 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sgl	NP_476980.1	PLN02353	1..459	CDD:177986	304/459 (66%)
sqv-4	NP_505730.1	PLN02353	11..471	CDD:177986	304/459 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165975
Domainoid	1	1.000	250	1.000	Domainoid score	I1156
eggNOG	1	0.900	-	-		E1_COG1004
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2520
Inparanoid	1	1.050	603	1.000	Inparanoid score	I506
Isobase	1	0.950	-	0	Normalized mean entropy	S2080
OMA	1	1.010	-	-		QHG60954
OrthoDB	1	1.010	-	-		D436314at33208
OrthoFinder	1	1.000	-	-		FOG0002453
OrthoInspector	1	1.000	-	-		oto20127
orthoMCL	1	0.900	-	-		OOG6_100511
Panther	1	1.100	-	-	LDO	PTHR11374
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6673
SonicParanoid	1	1.000	-	-		X2176
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790