DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sgl and plc-4

DIOPT Version :9

Sequence 1:	NP_476980.1	Gene:	sgl / 38760	FlyBaseID:	FBgn0261445	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_501213.1	Gene:	plc-4 / 177525	WormBaseID:	WBGene00004039	Length:	751	Species:	Caenorhabditis elegans

Alignment Length:	347	Identity:	63/347 - (18%)
Similarity:	129/347 - (37%)	Gaps:	64/347 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 DLKYVESAARMIAEIAQSNKIVVEKSTVPVRAAESIMHILRANQKPGIHYDILSNPEFLAEGTAI 165
            :|::.|..: ::..|  .|:.|.|.:.|.:::.:.:      |......::.:.|   ..:..|:
Worm    24 ELEWAEKGS-LLCRI--KNQKVKEMALVTIKSKQFL------NYYSSYWFNFVPN---ALKSVAL 76

  Fly   166 NDLLNADRVLIGGEETPEGHQAVEK------------LSWIYEHWIPKQNILTTNTWSSELSKLA 218
            ::||.    :..|.:|....:|.:|            .|.|:.|    ...|..:...|..||..
Worm    77 SELLE----VRSGYQTDNLQRASKKYEFQELAPESRCFSVIFSH----AKFLHKSVDFSADSKET 133

  Fly   219 ANAFLAQRISSINSLSAVCEATGADVSEVARAVGLDSRIGSKFLQASVGFGGSCFQKDILNLIYI 283
            .:.:    :|.:..|.:|.:......:|.|..:       .||.||.....|.....::.||:
Worm   134 RDKW----VSVLTHLISVAKHQRVVFNETAWLI-------DKFQQADTNKNGLLSFDEVWNLL-- 185

  Fly   284 CENLNLPEVAAYWQQVIDMNEYQKRR---FSQKIIESLFNTVSDKRIAILGFAFKKNTGDTRETA 345
             :.:||.....|.:.:...:|::..|   .::|...:.|..::|:  ..|.|...:.:.|..||.
Worm   186 -KRMNLQISERYAKAIFRESEFENSRDNKLNEKEFLNFFERLTDR--PDLRFVMTQASSDNVETL 247

  Fly   346 AITVCQTLLEEGAALDIYDPKVEPEQIIDDLTHPSVTESPEKVKKAVQIHSDPYSAVRATHALVI 410
            .:...|..|.|....:..|.| :.|||:.........:..||:...:.:..            ::
Worm   248 TVADLQRFLTEEQGFENVDLK-KAEQILTTFEQTVQDKQKEKLMGLMGMRR------------LM 299

  Fly   411 CTEWDEFVDLDFKRIYQSMMKP 432
            .:.|........:.|:|.|.:|
Worm   300 QSRWGNVFKPGHESIFQDMDQP 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sgl	NP_476980.1	PLN02353	1..459	CDD:177986	63/347 (18%)
plc-4	NP_501213.1	PH-like	29..145	CDD:302622	23/139 (17%)
		EF-hand_7	161..223	CDD:290234	13/71 (18%)
		EF-hand_10	176..226	CDD:291454	9/52 (17%)
		PLN02228	221..751	CDD:177873	22/116 (19%)
		EF-hand_like	231..315	CDD:286375	16/96 (17%)
		PI-PLCc_eukaryota	315..596	CDD:176501	3/7 (43%)
		C2_PLC_like	621..748	CDD:175974
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000