DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sgl and ugdh

DIOPT Version :9

Sequence 1:	NP_476980.1	Gene:	sgl / 38760	FlyBaseID:	FBgn0261445	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001103872.1	Gene:	ugdh / 116991	ZFINID:	ZDB-GENE-011022-1	Length:	493	Species:	Danio rerio

Alignment Length:	478	Identity:	316/478 - (66%)
Similarity:	391/478 - (81%)	Gaps:	3/478 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KVCCIGAGYVGGPTCAVMALKCPDIVITLVDKSSERIAQWNSDKLPIYEPGLDEVVKKCRNVNLF 66
            |:|||||||||||||:|:|..||:|.:|:||.:..||..||||.||||||||:|||..||..|||
Zfish     6 KICCIGAGYVGGPTCSVIASMCPEITVTVVDVNESRIKAWNSDTLPIYEPGLNEVVLSCRGKNLF 70

  Fly    67 FSTDIETAIKEADLIFISVNTPTKTCGNGKGRAADLKYVESAARMIAEIAQSNKIVVEKSTVPVR 131
            |||||::|||||||:||||||||||.|.|||||||||::|:.||.|.|::...|||.||||||||
Zfish    71 FSTDIDSAIKEADLVFISVNTPTKTYGMGKGRAADLKFIEACARRIVEVSDGYKIVTEKSTVPVR 135

  Fly   132 AAESIMHILRANQKPGIHYDILSNPEFLAEGTAINDLLNADRVLIGGEETPEGHQAVEKLSWIYE 196
            |||||..|..||.||.::..:||||||||||||:.||...|||||||:|||||.:|:..|..:||
Zfish   136 AAESIRRIFDANTKPSLNLQVLSNPEFLAEGTAVKDLKEPDRVLIGGDETPEGQRAISALCAVYE 200

  Fly   197 HWIPKQNILTTNTWSSELSKLAANAFLAQRISSINSLSAVCEATGADVSEVARAVGLDSRIGSKF 261
            ||:||..|:|||||||||||||||||||||||||||:||:||:|||||.|||||:|:|.||||||
Zfish   201 HWVPKTRIITTNTWSSELSKLAANAFLAQRISSINSISALCESTGADVEEVARAIGMDQRIGSKF 265

  Fly   262 LQASVGFGGSCFQKDILNLIYICENLNLPEVAAYWQQVIDMNEYQKRRFSQKIIESLFNTVSDKR 326
            |:|||||||||||||:|||:|:||.|||||||:||||||||||||::||:.:||:.|||||:.|:
Zfish   266 LKASVGFGGSCFQKDVLNLVYLCEALNLPEVASYWQQVIDMNEYQRKRFACRIIDCLFNTVTGKK 330

  Fly   327 IAILGFAFKKNTGDTRETAAITVCQTLLEEGAALDIYDPKVEPEQIIDDLTHPSVT-ESPEKVKK 390
            ||:|||:|||:||||||:::|.:.:.|::|||.|.||||||..||||.||:.|.:: ::||:|..
Zfish   331 IALLGFSFKKDTGDTRESSSIYISKYLMDEGAKLHIYDPKVLKEQIIQDLSQPGISGDNPERVSD 395

  Fly   391 AVQIHSDPYSAVRATHALVICTEWDEFVDLDFKRIYQSMMKPAYIFDGRKILD--HERLQQIGFH 453
            .|.:..|||.|..:.||||||||||.|.|||:::||..|:|||:|||||::||  |.:||.:||.
Zfish   396 LVTVTVDPYEACESAHALVICTEWDMFKDLDYEKIYHKMLKPAFIFDGRRVLDHLHTQLQNVGFQ 460

  Fly   454 VQTIGKKYQRTGLLRSWGIVPQL 476
            ::|||||........:.|.||::
Zfish   461 IETIGKKVMTRIPFTTSGGVPRI 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sgl	NP_476980.1	PLN02353	1..459	CDD:177986	310/459 (68%)
ugdh	NP_001103872.1	PLN02353	4..466	CDD:177986	310/459 (68%)
		UDPG_MGDP_dh_N	6..193	CDD:281683	129/186 (69%)
		UDPG_MGDP_dh	214..309	CDD:279344	81/94 (86%)
		UDPG_MGDP_dh_C	332..449	CDD:281682	66/116 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594185
Domainoid	1	1.000	267	1.000	Domainoid score	I1839
eggNOG	1	0.900	-	-		E1_COG1004
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2520
Inparanoid	1	1.050	656	1.000	Inparanoid score	I754
OMA	1	1.010	-	-		QHG60954
OrthoDB	1	1.010	-	-		D436314at33208
OrthoFinder	1	1.000	-	-		FOG0002453
OrthoInspector	1	1.000	-	-		oto40256
orthoMCL	1	0.900	-	-		OOG6_100511
Panther	1	1.100	-	-	O	PTHR11374
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6673
SonicParanoid	1	1.000	-	-		X2176
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	17	17.300