DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sgl and Plce1

DIOPT Version :9

Sequence 1:	NP_476980.1	Gene:	sgl / 38760	FlyBaseID:	FBgn0261445	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_446210.1	Gene:	Plce1 / 114633	RGDID:	69424	Length:	2281	Species:	Rattus norvegicus

Alignment Length:	326	Identity:	70/326 - (21%)
Similarity:	112/326 - (34%)	Gaps:	104/326 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 SDKLPIY------------EPGLDEVVKKCRNVNLFFST---------DIETAIKEADLIFISVN 86
            |:..|:|            :|.||.:.:...::.||..:         .|..||..|.::
  Rat  1230 SESTPLYTNLTIEENTNDLQPDLDLLTRNVSDLGLFMKSKQQLSDNQRQISDAIAAASIV----- 1289

  Fly    87 TPTKTCGNGKGRAADLKYVESAARMI--AEIAQSNKIVV----EKSTVPVRAAESIMHILRANQK 145
                  .||.|       :||.:..|  ..|.|.|..:|    |..|.     :.|:.|:: ..:
  Rat  1290 ------TNGTG-------IESTSLGIFGVGILQLNDFLVNCQGEHCTY-----DEILSIIQ-KFE 1335

  Fly   146 PGI---HYDILSNPEFLAEGTAINDLLNADRVLIGGEETPEGHQAVE-KLSWIY---EHWIPKQN 203
            |.|   |..:||     .||.| ..|::.|......:|:.|..:.:: .||:.|   .|    ..
  Rat  1336 PNISMCHQGLLS-----FEGFA-RFLMDKDNFASKNDESRENKKDLQLPLSYYYIESSH----NT 1390

  Fly   204 ILTTNTWSSELSKLAANAFLAQRISSI--------NSLSAVCE----ATGADVSEVARAVGLDSR 256
            .||.:....|.|....:..|.|...||        :.:..:..    .|.....||..|:...:.
  Rat  1391 YLTGHQLKGESSVELYSQVLLQGCRSIELDCWDGDDGMPIIYHGHTLTTKIPFKEVVEAIDRSAF 1455

  Fly   257 IGSKFLQASVGFGGSCFQKDILNLIYICENLNLPEVAAYWQQVIDMNEYQKRRFSQKII-ESLFN 320
            |.|                |:..:|.|..:.:||       |...|.|..|..|.:|:: :.||.
  Rat  1456 ITS----------------DLPIIISIENHCSLP-------QQRKMAEIFKSVFGEKLVAKFLFE 1497

  Fly   321 T 321
            |
  Rat  1498 T 1498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sgl	NP_476980.1	PLN02353	1..459	CDD:177986	70/326 (21%)
Plce1	NP_446210.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..68
		GRF CDC25 domain	529..740
		RasGEF	531..710	CDD:279011
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1050..1146
		PLN02952	1299..1962	CDD:178538	53/239 (22%)
		EF-hand_like	<1309..1360	CDD:286375	16/62 (26%)
		PI-PLCc_epsilon	1372..1812	CDD:176538	32/154 (21%)
		PIPLC X domain	1373..1521		32/153 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1547..1572
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1664..1703
		PIPLC Y domain	1734..1824
		C2 domain	1839..1923
		C2_PLC_like	1847..1963	CDD:175974
		RA1 domain	1989..2093
		RA2 domain	2114..2217
		PLC_epsilon_RA	2116..2215	CDD:176375
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2239..2281
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000