DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sgl and LOC100537538

DIOPT Version :9

Sequence 1:	NP_476980.1	Gene:	sgl / 38760	FlyBaseID:	FBgn0261445	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_021322946.1	Gene:	LOC100537538 / 100537538	-ID:	-	Length:	1213	Species:	Danio rerio

Alignment Length:	499	Identity:	87/499 - (17%)
Similarity:	159/499 - (31%)	Gaps:	133/499 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 DEVVKKCRNVNLFFS--------TDIETAIKEADLIFISVNTPTKTCGNGKGRAADLKYVESAAR 110
            ||:.::....:.|:|        ||||...|:.                 ||...|  |:
Zfish   223 DEIQREIFTFDKFYSLTQKICPRTDIEVLFKKF-----------------KGDKGD--YL----- 263

  Fly   111 MIAEIAQSNKIVVEKSTVPVRAAESIMHILRANQKPGIHYDILSNPEFLA-------------EG 162
                                 :.|..:|.|..||:.....:||. |.|.:             |.
Zfish   264 ---------------------SVEQFVHFLNDNQRDPRLNEILF-PFFNSKCAFQIIQRYEPDEK 306

  Fly   163 TAINDLLNAD---RVLIGGEETP---EGHQAVEKLSWIYEHWIPKQNILTTNTWSSELSKLAANA 221
            .....||:.|   |.|:..|..|   :..:..:::.....|:....:..|..|......|.:...
Zfish   307 LKRKGLLSCDGFCRFLMSDENAPVFLDRLEVYQEMDHPLSHYFINSSHNTYLTGRQFGGKSSVEI 371

  Fly   222 FLAQRISSINSLSAVC-EATGADVSEV---ARAVGLDSRI-----GSK---FLQAS----VGFGG 270
            :....::....:...| :..|.|...:   .:|:..|...     |.|   ||.:.    :.|..
Zfish   372 YRQVLLTGCRCVELDCWDGKGEDQEPIITHGKAMCTDVLFKDVIQGIKETAFLTSEYPVILSFEN 436

  Fly   271 SCFQKDILNLIYICENL-------------------NLPEVAAYWQQVIDMNEYQKRRFSQKIIE 316
            .|.:.....|...||::                   .||.......:::..|...|....:|.:|
Zfish   437 HCTKHQQYKLARYCEDIFGDLLLKQPLEDFPMEPGCPLPSPNDLKGKILIKNRRLKPEVEKKQLE 501

  Fly   317 SLFNTVSDKRIAILGFAFKKNTGDTRETA---------AITVCQTLLEEGAALDIY--DPKVEPE 370
            .....:.....::....|:....|...||         .|..|....||....::.  ..|.|.|
Zfish   502 DFRKHMEAGEPSVSTNLFEDENEDETNTAELLNEAHPERIHGCLITEEENREEEVLLRHRKAEEE 566

  Fly   371 QIIDDLTHPSVTESPEKVKKAVQIHSDPYSAVRATHALVICTEWDEFVDLDFKRIYQSMMKPAYI 435
            .:.|:|   :|.:|...|.....||  ||.:....:|..:  ::..|.:.:.|.|:.:|..
Zfish   567 NVADEL---AVIQSYTYVAATTNIH--PYLSNIINYAQAV--KFTGFDEAEEKNIHHNMSS---- 620

  Fly   436 FD---GRKILDHERLQQIGFHVQTIGKKYQRTGLLRSWGIVPQL 476
            |:   |...|....::.:.::.:.:.:.|.:.|.:.|...:||:
Zfish   621 FNESVGLGYLRTNAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQI 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sgl	NP_476980.1	PLN02353	1..459	CDD:177986	82/480 (17%)
LOC100537538	XP_021322946.1	PH_PLC_beta	43..169	CDD:270167
		EFh_PI-PLC	174..326	CDD:333715	28/148 (19%)
		EF-hand motif	174..203	CDD:320029
		EF-hand motif	209..237	CDD:320029	3/13 (23%)
		EF-hand motif	247..276	CDD:320029	11/73 (15%)
		EF-hand motif	293..326	CDD:320029	6/32 (19%)
		PI-PLCc_beta	338..694	CDD:176533	57/338 (17%)
		C2_PLC_like	728..844	CDD:175974
		DUF1154	937..>962	CDD:310911
		PLC-beta_C	1063..1184	CDD:312287
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000