DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sgl and plcg1

DIOPT Version :9

Sequence 1:	NP_476980.1	Gene:	sgl / 38760	FlyBaseID:	FBgn0261445	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_012808222.3	Gene:	plcg1 / 100496674	XenbaseID:	XB-GENE-982496	Length:	1274	Species:	Xenopus tropicalis

Alignment Length:	395	Identity:	81/395 - (20%)
Similarity:	128/395 - (32%)	Gaps:	161/395 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 ILSNPEFLAEGTAI-----------NDLLNADRVLIGGEETPEGHQAVEKLSWIYEHWIPKQNIL 205
            ||...:.||||:..           ||:.|:.:..|...:.|..|:           |.|...:|
Frog   452 ILIKHKKLAEGSTYEEIPASTVYSENDISNSIKNGILYLQDPINHE-----------WYPHFFVL 505

  Fly   206 TTN-----------------------TWSSEL--------SKLAA---NAFLAQRISSINSLSAV 236
            |::                       :.||||        .||.|   ...:|:|:     |:..
Frog   506 TSSKIYYSEETTGSQANDDEEEQKEASNSSELHSAEKWFHGKLGAGRDGRHIAERL-----LTDY 565

  Fly   237 CEATGAD-----VSEVARAVG------------LDSRIGSKFLQASVGFGGSCFQKDILNLIYIC 284
            |..|||.     |.|....||            ...||.|:....|..|    |..|  ||::
Frog   566 CIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQEAGSPKF----FLTD--NLVF-- 622

  Fly   285 ENLNLPEVAAYWQQVIDMNEYQKRRFSQKIIESLFNTVSDKRIAILGFAFKKNTGDTRE--TAAI 347
            |:| ...:..|.|..:..||::.|     :.|.:..|               |..:::|  .|::
Frog   623 ESL-YALITHYQQMPLRCNEFEMR-----LTEPVPQT---------------NAHESKEWYHASL 666

  Fly   348 T------VCQTLLEEGAALDIYDPKVEPEQIIDDLTHPSVTESPEKVKKAVQIHSDPYSAVRATH 406
            |      :...:..:||.|                    |.:..|:...|:...::.    :..|
Frog   667 TRGQAEHMLMRVPRDGAFL--------------------VRKRSEQNSYAISFRAEG----KIKH 707

  Fly   407 ALVI---------CTEWDEFVDLDFKRIYQSMMKPAYIFDGRKI-----LDHERLQQIGFHVQTI 457
            ..||         .:|:|..|||    |......|.|    ||:     ::.|.|::||......
Frog   708 CRVIQEGQSVVLGSSEFDSLVDL----ISYYEKHPLY----RKMKLRYPINEETLEKIGTPDPDY 764

  Fly   458 GKKYQ 462
            |..|:
Frog   765 GALYE 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sgl	NP_476980.1	PLN02353	1..459	CDD:177986	79/390 (20%)
plcg1	XP_012808222.3	PH_PLC_gamma	27..149	CDD:270168
		EFh_PI-PLC	154..299	CDD:333715
		PI-PLCc_gamma	312..>459	CDD:176534	2/6 (33%)
		PH-like	482..>519	CDD:418428	7/47 (15%)
		SH2_N-SH2_PLC_gamma_like	538..642	CDD:199829	28/117 (24%)
		SH2_C-SH2_PLC_gamma_like	656..758	CDD:198186	24/133 (18%)
		SH3_PLCgamma1	784..843	CDD:212903
		PHsplit_PLC_gamma	<857..926	CDD:270054
		PLCYc	947..1062	CDD:128454
		C2_PLC_like	1079..1204	CDD:175974
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000