DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sgl and plcl2

DIOPT Version :9

Sequence 1:	NP_476980.1	Gene:	sgl / 38760	FlyBaseID:	FBgn0261445	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_002932453.1	Gene:	plcl2 / 100489093	XenbaseID:	XB-GENE-949595	Length:	1113	Species:	Xenopus tropicalis

Alignment Length:	418	Identity:	79/418 - (18%)
Similarity:	140/418 - (33%)	Gaps:	167/418 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 AEGTAIND------LLNADRVLI-----GGEETPEGHQAVEKLSWIYEHWIPKQNIL-------- 205
            :.|...||      :.|.|.|::     .|...||....|.|      |.:|:::.:
Frog    44 SNGKCSNDCTINSAVSNGDCVIVEAKEESGPALPESPGIVSK------HGLPRRSSIIKDGTKQK 102

  Fly   206 ----TTNTWS---------------------SELSKLAANAFLAQRISSINS------------- 232
                .|.::|                     |||.|:.:|:.:..|...:::
Frog   103 RERKKTVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKD 167

  Fly   233 -------LSAVCEATGADVSEVARAVGLDSRIGSKFLQASVGFGGSCFQKDILNLIYICENLNLP 290
                   :.:|.|......:::.|:.|:..:| |:....|:.:|.:....|::        .|..
Frog   168 SEKAKIDIKSVKEVRTGKNTDIFRSNGIYDQI-SEDCAFSIIYGENYESLDLV--------ANSA 223

  Fly   291 EVAAYW-----------QQVIDMNEYQKRRFSQKIIESLFNTVSDKRIAILGFAFK----KNTGD 340
            :||..|           :..:||            |||..:.:   ||:.|...|:    :||||
Frog   224 DVANVWVTGLRYLISYGKHTLDM------------IESFQDNM---RISWLSQMFRELDEENTGD 273

  Fly   341 TRETAAITVCQTLLEEGAALDIYDPKVEPEQIIDDLTHPSVTESPEKVKKAVQIHSDPYSAVRAT 405
            .....|:...:.|          :|.::..:|  :|....:.:|.|||...|
Frog   274 IPLCKAVQFIKNL----------NPGLKNSKI--ELKFKELQKSKEKVSTEV------------- 313

  Fly   406 HALVICTEWDEFVDLDFKRIYQSMMKPAYIF------DGRKILDHERL------QQIGFHVQ--- 455
                  |: |||:::    .::...:|...|      ..::.||.:.|      :|...||.
Frog   314 ------TK-DEFIEV----FHELCTRPEIYFLLVQFSSNKEYLDTKDLMMFLEAEQGMAHVTEEI 367

  Fly   456 --TIGKKY-----QRTGLLRSWGIVPQL 476
              .|.|||     |.||.|...|:...|
Frog   368 SLDIIKKYEPSKGQETGSLSLDGLTSYL 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sgl	NP_476980.1	PLN02353	1..459	CDD:177986	70/394 (18%)
plcl2	XP_002932453.1	PH_PLC_eta	130..238	CDD:270170	19/116 (16%)
		EFh_PI-PLC	258..400	CDD:333715	38/174 (22%)
		EF-hand motif	258..287	CDD:320029	8/38 (21%)
		EF-hand motif	294..325	CDD:320029	11/56 (20%)
		EF-hand motif	330..358	CDD:320029	4/27 (15%)
		EF-hand motif	367..399	CDD:320029	10/29 (34%)
		PI-PLCc_PRIP_metazoa	411..707	CDD:176539
		C2_PLC_like	739..867	CDD:175974
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000