DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sgl and LOC100488276

DIOPT Version :9

Sequence 1:	NP_476980.1	Gene:	sgl / 38760	FlyBaseID:	FBgn0261445	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_002942363.2	Gene:	LOC100488276 / 100488276	-ID:	-	Length:	1102	Species:	Xenopus tropicalis

Alignment Length:	538	Identity:	106/538 - (19%)
Similarity:	186/538 - (34%)	Gaps:	154/538 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 DIVITLVDKSSERIAQWNSDKLPIYEPGLDEVVKKCRNVNLFFSTDIETAIKEADLIFISVNTPT 89
            :|...|.:...|.:.:....||.:.:. |.::|..|::|..   .|.||:  .:...:..|::..
Frog   563 EIARRLGNDGEEHLGEAGHRKLRLCKE-LSDLVNLCQSVKF---RDFETS--RSSQKYWQVSSFN 621

  Fly    90 KTCGNGKGRAADLKYVESAARMIAEIAQSNKIVVEKSTVPVRAAESIMHILRAN-QKPGIHYDI- 152
            :...:........::|....|.::.:..|:..:...:..|....:....|:..| |.||:..|:
Frog   622 EVAASRFSNEYPEEFVRYNKRFLSRVYPSSMRIDASNMNPQDFWKCGCQIVAMNFQTPGLMMDLN 686

  Fly   153 ------------LSNPEFLAEGTAINDLLNADRV-----------LIGGEE--TPEGHQA----V 188
                        :..|..:.|..:.......|.:           :|.|:.  .|:|..|    |
Frog   687 TGWFRQNGNCGYVLRPAIMREEVSYFSANAKDSLPGVSAQLLYIKIISGQNLPKPKGSGAKGDVV 751

  Fly   189 EKLSWIYEHWIP------KQNILTTN----------TWSSELSKLA------------ANAFLAQ 225
            |...::..|.||      :...:|.|          .:...|.:||            .:.|:||
Frog   752 EPYVYVEIHGIPADCAEHRTKTVTQNGDNPIFDESFEFHINLPELAILRFVVLDDDFIGDEFIAQ 816

  Fly   226 RISSINSLSAVCEATGADVSEVARAVGLDSRIGSKFLQASVGF---------GGSCFQKDILNLI 281
                 .::...|..||      .|.|.|.|..| :|||.:..|         ||...||..|
Frog   817 -----YTIPFECLQTG------FRHVPLQSLTG-EFLQNTTLFVHIAITNRRGGGKAQKKGL--- 866

  Fly   282 YICENLNLPEVAAYWQQVIDMNEYQKRRFSQ-KIIESLFNT-------VSDKRIAILG--FAFKK 336
                         |.::...:.||...:.:. |.|:.:|.|       .:|.|..:..  .:||:
Frog   867 -------------YVRKGKKVREYTSTKTTGIKAIDEVFRTATPSLREATDLRENVQNALVSFKE 918

  Fly   337 NTGDT----RETAAITVCQTLLEEGAALDI-------YDPKVEPEQIIDDLTHPSVTESPEKVKK 390
            ..|.|    .:...:||...||...:.|.:       | |.:|.:..:           ||.:||
Frog   919 LCGLTPAANMKQCILTVSAWLLNNDSPLTVTLNLRSQY-PTLEAQGPV-----------PELLKK 971

  Fly   391 AVQIHSDPYSA-VRATHALVICTEWDEFVDLDFKRIYQSMMKPAYIFDGRKILDHERLQQIGFHV 454
            .:.    .|.| ::|:..|:      |..|:.:.:|.| :.|....|       ||.|.:||...
Frog   972 VLA----SYEAFIQASRTLI------ETADVVYSKIIQ-VQKAGMGF-------HEDLHRIGAKE 1018

  Fly   455 QTIGKKYQRTGLLRSWGI 472
            ...|:|.|:.....:|.|
Frog  1019 GLKGRKLQKVMESFAWNI 1036

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sgl	NP_476980.1	PLN02353	1..459	CDD:177986	101/523 (19%)
LOC100488276	XP_002942363.2	PH_PLC_eta	115..223	CDD:270170
		EFh_PRIP	243..385	CDD:320036
		EF-hand motif	243..272	CDD:320036
		EF-hand motif	279..311	CDD:320036
		EF-hand motif	315..343	CDD:320036
		EF-hand motif	352..385	CDD:320036
		PI-PLCc_GDPD_SF	397..693	CDD:387364	23/135 (17%)
		C2_PLC_like	725..853	CDD:175974	30/139 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000