DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sgl and plcb4

DIOPT Version :9

Sequence 1:	NP_476980.1	Gene:	sgl / 38760	FlyBaseID:	FBgn0261445	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_002931782.1	Gene:	plcb4 / 100125098	XenbaseID:	XB-GENE-1010443	Length:	1205	Species:	Xenopus tropicalis

Alignment Length:	444	Identity:	89/444 - (20%)
Similarity:	156/444 - (35%)	Gaps:	155/444 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PTCAVMALKCPDIVITLVDKSSERIAQWNSDK-------LPIYEPGLDEVVKKCRNVNLFFSTDI 71
            |...|:|..|...||:         .|:.|||       :.:|....|.:.|:.| ..:..:..:
Frog   706 PVDGVIAATCSVQVIS---------GQFLSDKKIGTYVEVDMYGLPTDTIRKEFR-TRMVMNNGL 760

  Fly    72 ETAIKEADLIFISVNTPTKTCGNGKGRAADLKYVESAARMIAEIAQSNKIVVEKSTVPVRAAES- 135
            .....:...:|..|..|            ||     |...||....:||::.:: .:|:...::
Frog   761 NPVYNDEPFVFRKVILP------------DL-----AVLRIAVYDDNNKLIGQR-ILPLDGLQAG 807

  Fly   136 IMHILRANQ--KP--------------------GIHYDILSNP-EFLAEGTAINDLLNADRVLIG 177
            ..||...|:  ||                    |...|.||:| :||    :|.: ..||::...
Frog   808 YRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFL----SITE-KRADQMRAM 867

  Fly   178 GEETPEGHQAVEKLSWIYEHWIPKQNILTTNTWSSELSKLAANAFLAQRISSINSLSAVCEATGA 242
            |.||.:          |.:  :|..|  |.|....:.|....|                  .|..
Frog   868 GIETSD----------IAD--VPADN--TKNDKKGKTSNAKTN------------------VTPQ 900

  Fly   243 DVSEVARAVGLDSRIGSKFLQASVGFGGSCFQKDILNLIYICEN---LNLPEVAAYWQQVIDMNE 304
            ..|||..:|           .|:.|.|              .||   :::|:|..  :::..|..
Frog   901 SSSEVRPSV-----------TAAPGAG--------------TENKKAIDIPQVKV--EELKQMKA 938

  Fly   305 YQKRRFSQK---------------IIESLFNTVSDKRIAILGFAFKKNTGDTRETAAITVCQTLL 354
            :.|::..|:               :::.|..|..||.:|...   |:.....|     |:.:::.
Frog   939 FLKQQKKQQKEIAALKKKHLKEHSVVQKLQCTQVDKIVAQFD---KEKVSHER-----TLEKSIK 995

  Fly   355 EEGAALDIYDPKVEPEQIIDDLTHPSVTESPEKVKKAVQIHSDPYS-AVRATHA 407
            ::||: :.::.|.|.|..|..||    ::...|||..|..|:..:: .|:|.:|
Frog   996 KKGAS-NCHEMKKETENKIQVLT----SDHKSKVKDIVAQHTKEFTEMVKAQNA 1044

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sgl	NP_476980.1	PLN02353	1..459	CDD:177986	89/444 (20%)
plcb4	XP_002931782.1	PH_PLC_beta	17..143	CDD:270167
		EFh_PI-PLCbeta4	148..300	CDD:320041
		PLN02228	285..819	CDD:177873	28/140 (20%)
		PI-PLCc_beta	312..680	CDD:176533
		DUF1154	923..966	CDD:399553	5/44 (11%)
		PLC-beta_C	1022..1168	CDD:400858	8/23 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000