DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10077 and Ddx59

DIOPT Version :9

Sequence 1:	NP_001261491.1	Gene:	CG10077 / 38756	FlyBaseID:	FBgn0035720	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_080776.1	Gene:	Ddx59 / 67997	MGIID:	1915247	Length:	619	Species:	Mus musculus

Alignment Length:	417	Identity:	139/417 - (33%)
Similarity:	236/417 - (56%)	Gaps:	9/417 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 YKPCDSVLARTVGETETFLTSNEITIKGDQVPTPSIEFEEGGFPDYVMNEIRKQGFAKPTAIQAQ 186
            ||....::.....:.||......|:::|..|..|.|:||..|||:.:...::|.|:..||.||.|
Mouse   168 YKEHPFIVTLKEDQIETLKQQLGISVQGQDVARPIIDFEHCGFPETLNQNLKKSGYEVPTPIQMQ 232

  Fly   187 GWPIAMSGRDLVGVAQTGSGKTLAYVLPAVVHINNQPRLERGDGPIALVLAPTRELAQQIQQVAI 251
            ..|:.:.|||::..|.||||||.|::||.::...::.:.     |.||:|.||||||.||::.|.
Mouse   233 MIPVGLLGRDILASADTGSGKTAAFLLPVIIRAFSEDKT-----PSALILTPTRELAIQIERQAK 292

  Fly   252 EFGSN-THVRNTCIFGGAPKGQQARDLERGVEIVIATPGRLIDFLERGTTSLKRCTYLVLDEADR 315
            |..|. ..::...:.||.|...|...|.:.|:::|||||||:|.:::.:.||.....:|:||||.
Mouse   293 ELMSGLPRMKTVLLVGGLPLPPQLYRLRQHVKVIIATPGRLLDIIKQSSVSLSGIKIVVVDEADT 357

  Fly   316 MLDMGFEPQIRKIMQQIRPDRQVLMWSATWPKEVRQLAEEFLNNYIQVNIGSLSLSANHNILQIV 380
            ||.|||:.|:..:::....|.|.::.|||.|..:.||.::.|:|.:::..|..:|.. .::.||:
Mouse   358 MLKMGFQQQVLDVLEHTPGDCQTILVSATIPDSIEQLTDQLLHNPVRIITGDKNLPC-ASVRQII 421

  Fly   381 DVCDENEKLMKLIKLLTDISAENETKTIIFVETKKRVDEITRNISR-QGWRACAIHGDKSQQERD 444
            ...::..|..||.::|.| ....:...::||:.|...|.::..:.: .|..:.:||.:|||.||.
Mouse   422 LWVEDPAKKKKLFEILND-QKLFKPPVLVFVDCKLGADLLSEAVQKITGLNSTSIHSEKSQVERR 485

  Fly   445 FVLSSFRNGRHSILVATDVAARGLDVDDVKFVINYDYPSNSEDYVHRIGRTGRSNNTGTAYTLFT 509
            .:|.....|.:.::|:|.|..||||:.:||.|:|:|.||:.::|||::||.||....|||.|...
Mouse   486 DILKGLLEGDYEVVVSTGVLGRGLDLVNVKLVVNFDMPSSMDEYVHQVGRVGRLGQNGTAITFIN 550

  Fly   510 HSNANKANDLIQVLREANQTINPKLMN 536
            :::.....|:.:.::.....:.|:|:|
Mouse   551 NNSKRLFWDVAKRVKPTGSILPPQLLN 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10077	NP_001261491.1	PTZ00110	49..544	CDD:240273	139/417 (33%)
		DEADc	159..364	CDD:238167	78/205 (38%)
		HELICc	375..507	CDD:238034	45/132 (34%)
Ddx59	NP_080776.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..101
		PLN00206	70..593	CDD:215103	139/417 (33%)
		Q motif	203..231		11/27 (41%)
		DEAD box	353..356		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	583..603
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0331
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810