DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10077 and Ddx17

DIOPT Version :9

Sequence 1:	NP_001261491.1	Gene:	CG10077 / 38756	FlyBaseID:	FBgn0035720	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_951062.1	Gene:	Ddx17 / 67040	MGIID:	1914290	Length:	652	Species:	Mus musculus

Alignment Length:	781	Identity:	365/781 - (46%)
Similarity:	434/781 - (55%)	Gaps:	170/781 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 MNGGGPSMGPGGPRNQD----GFGGQNGG----QRSSNHGAHLPKIVWSEVNLTPFRKNFYKPCD 126
            |.|||     .|.|::|    |||.:.|.    ::..|.|..|.|..|....|..|.||||....
Mouse     1 MRGGG-----FGDRDRDRDRGGFGARGGSGLPPKKFGNPGERLRKKKWDLSELPKFEKNFYVEHP 60

  Fly   127 SVLARTVGETETFLTSNEITIK-GDQVPTPSIEFEEGGFPDYVMNEIRKQGFAKPTAIQAQGWPI 190
            .|...|..|.:......|||:: ||..|.|...|....||.|||:.:..|.|.:||.||.||:|:
Mouse    61 EVARLTPYEVDELRRKKEITVRGGDVCPKPVFAFHHANFPQYVMDVLMDQHFTEPTPIQCQGFPL 125

  Fly   191 AMSGRDLVGVAQTGSGKTLAYVLPAVVHINNQPRLERGDGPIALVLAPTRELAQQIQQVAIEFGS 255
            |:||||:||:|||||||||||:|||:||||:||.||||||||.||||||||||||:||||.::|.
Mouse   126 ALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYLERGDGPICLVLAPTRELAQQVQQVADDYGK 190

  Fly   256 NTHVRNTCIFGGAPKGQQARDLERGVEIVIATPGRLIDFLERGTTSLKRCTYLVLDEADRMLDMG 320
            .:.:::|||:||||||.|.|||||||||.||||||||||||.|.|:|:|||||||||||||||||
Mouse   191 CSRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLESGKTNLRRCTYLVLDEADRMLDMG 255

  Fly   321 FEPQIRKIMQQIRPDRQVLMWSATWPKEVRQLAEEFLNNYIQVNIGSLSLSANHNILQIVDVCDE 385
            ||||||||:.|||||||.||||||||||||||||:||.:|.|:|:|:|.||||||||||||||.|
Mouse   256 FEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRDYTQINVGNLELSANHNILQIVDVCME 320

  Fly   386 NEKLMKLIKLLTDISAENETKTIIFVETKKRVDEITRNISRQGWRACAIHGDKSQQERDFVLSSF 450
            :||..|||:|:.:|.||.|.|||||||||:|.|::||.:.|.||.|..|||||||.|||:||:.|
Mouse   321 SEKDHKLIQLMEEIMAEKENKTIIFVETKRRCDDLTRRMRRDGWPAMCIHGDKSQPERDWVLNEF 385

  Fly   451 RNGRHSILVATDVAARGLDVDDVKFVINYDYPSNSEDYVHRIGRTGRSNNTGTAYTLFTHSNANK 515
            |:|:..||:|||||:|||||:|||||||||||::|||||||||||.||.|.|||||.||..|..:
Mouse   386 RSGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYVHRIGRTARSTNKGTAYTFFTPGNLKQ 450

  Fly   516 ANDLIQVLREANQTINPKLMNMAMNGGYNKRGGGMGGGYRGGNGYQ----GRNPQM--------- 567
            |.:||:||.||||.||||||.:.     :.||||.|||..|.:.|:    ..||.:
Mouse   451 ARELIKVLEEANQAINPKLMQLV-----DHRGGGGGGGKGGRSRYRTTSSANNPNLMYQDECDRR 510

  Fly   568 -----GGGYNGGNNYRNNNGPGATMNRNSFNGGSAGGPPRFDQKPRTSPPNQGGQGGYRGQGGGG 627
                 .||.....:||:.:                       :..|.|..|           |.|
Mouse   511 LRGVKDGGRRDSTSYRDRS-----------------------ETDRASYAN-----------GSG 541

  Fly   628 YQGQQQQQQQQNGGVPFSRFNPNAACFEPNKPQNGPGSGPPQAQHQQQQQAQAAQQQHLLPDASV 692
            |            |.|.|.|.                             |||.|..:      .
Mouse   542 Y------------GSPNSAFG-----------------------------AQAGQYTY------A 559

  Fly   693 QAAMTAANYGVDQKRSRFSPYN-MNFANMPPPAMNQQQAAAAQQQQQQQL-------QTPQQQQQ 749
            |....||.||.       |.|. ..:|.....|.:...|..:.|...||.       |.||....
Mouse   560 QGTYGAAAYGT-------SGYTAQEYAAGTYGASSTASAGRSSQSSSQQFSGIGRSGQQPQPLMS 617

  Fly   750 QQQMQQPQAYGQYSSMSSSMATVSLNGGAAAVASSYRAPYAVPTQAAPYMMANGGDIFAYPPPPL 814
            ||..|.|.|                                  |....||   |...:.|||||.
Mouse   618 QQFAQPPGA----------------------------------TNMIGYM---GQTAYQYPPPPP 645

  Fly   815 P 815
            |
Mouse   646 P 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10077	NP_001261491.1	PTZ00110	49..544	CDD:240273	305/482 (63%)
		DEADc	159..364	CDD:238167	153/204 (75%)
		HELICc	375..507	CDD:238034	93/131 (71%)
Ddx17	NP_951062.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38		13/41 (32%)
		DEXDc	32..502	CDD:331760	305/474 (64%)
		Q motif	92..120		11/27 (41%)
		DEAD box	246..249		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	585..652		23/99 (23%)
		Interaction with YAP1. /evidence=ECO:0000250\|UniProtKB:Q92841	641..649		5/6 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850185
Domainoid	1	1.000	287	1.000	Domainoid score	I1574
eggNOG	1	0.900	-	-		E2759_KOG0331
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	618	1.000	Inparanoid score	I887
Isobase	1	0.950	-	0	Normalized mean entropy	S387
OMA	1	1.010	-	-		QHG53695
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000439
OrthoInspector	1	1.000	-	-		otm43919
orthoMCL	1	0.900	-	-		OOG6_100364
Panther	1	1.100	-	-	O	PTHR47958
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R290
SonicParanoid	1	1.000	-	-		X504
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.740