DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10077 and ddx59

DIOPT Version :9

Sequence 1:	NP_001261491.1	Gene:	CG10077 / 38756	FlyBaseID:	FBgn0035720	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001038443.2	Gene:	ddx59 / 562123	ZFINID:	ZDB-GENE-050208-665	Length:	584	Species:	Danio rerio

Alignment Length:	452	Identity:	147/452 - (32%)
Similarity:	234/452 - (51%)	Gaps:	24/452 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 FGGQNGGQRSSNHGAHLPKIVWSEVNLTPFRKNF-YKPCDSVLARTVGETETFLTSNEITIKGDQ 151
            |..:|..:.|.|                  .||: ||....:...|..:.|.......|...|.:
Zfish   118 FNNKNTPESSEN------------------TKNYCYKEDTFISELTEEQIERVKAELGIVSVGTE 164

  Fly   152 VPTPSIEFEEGGFPDYVMNEIRKQGFAKPTAIQAQGWPIAMSGRDLVGVAQTGSGKTLAYVLPAV 216
            |..|.|||:...||..:...::..|:..||.:|.|..|:.::|||::..|.||||||:|::||.|
Zfish   165 VCRPVIEFQHCRFPTVLEKNLKVAGYEAPTPVQMQMVPVGLTGRDVIATADTGSGKTVAFLLPVV 229

  Fly   217 VHINNQPRLERGDGPIALVLAPTRELAQQIQQVAIEFGSN-THVRNTCIFGGAPKGQQARDLERG 280
            :.. .|........|..|:|.||||||.||::.|.|.... .::|...:.||.|...|...|:..
Zfish   230 MRA-LQSESASPSCPACLILTPTRELAIQIEEQAKELMRGLPNMRTALLVGGMPLPPQLHRLKHN 293

  Fly   281 VEIVIATPGRLIDFLERGTTSLKRCTYLVLDEADRMLDMGFEPQIRKIMQQIRPDRQVLMWSATW 345
            ::|||.|||||::.|::....|.....:|:||||.||.|||:.|:..|::|:..|.|.|:.|||.
Zfish   294 IKIVIGTPGRLLEILKQKAIQLDHVRTVVVDEADTMLKMGFQQQVLDILEQVPEDHQTLLTSATI 358

  Fly   346 PKEVRQLAEEFLNNYIQVNIGSLSLSANHNILQIVDVCDENEKLMKLIKLLTDISAENETKTIIF 410
            |...:||||...::.:.:.||..:... .|:.|||...:|..|..||.::|.| ....:...::|
Zfish   359 PTGTQQLAERLTHDPVTITIGQKNQPC-ANVRQIVLWVEEPSKKKKLFEILND-EKLYQPPVVVF 421

  Fly   411 VETKKRVDEITRNISR-QGWRACAIHGDKSQQERDFVLSSFRNGRHSILVATDVAARGLDVDDVK 474
            |:.|...|.:...:.: ......|||.||.|.||:.::.....|:..::::|.:..||||:.:||
Zfish   422 VDCKLGADLLCEAVQKVMSLNTVAIHSDKMQWERNKIVKGLLEGQFDVVISTGILGRGLDLVNVK 486

  Fly   475 FVINYDYPSNSEDYVHRIGRTGRSNNTGTAYTLFTHSNANKANDLIQVLREANQTINPKLMN 536
            .|||:|.|||.::|||:|||.||..:.|||.|...::|.....::::.::.....:.|:::|
Zfish   487 LVINFDMPSNMDEYVHQIGRAGRLGHRGTAITFMNNNNKRLFLEMVKRVKPTGSILPPQILN 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10077	NP_001261491.1	PTZ00110	49..544	CDD:240273	147/452 (33%)
		DEADc	159..364	CDD:238167	77/205 (38%)
		HELICc	375..507	CDD:238034	48/132 (36%)
ddx59	NP_001038443.2	PLN00206	60..562	CDD:215103	147/452 (33%)
		zf-HIT	75..102	CDD:282314
		DEADc	183..377	CDD:238167	74/194 (38%)
		HELICc	387..519	CDD:238034	48/132 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0331
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810