DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10077 and DDX41

DIOPT Version :9

Sequence 1:	NP_001261491.1	Gene:	CG10077 / 38756	FlyBaseID:	FBgn0035720	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_057306.2	Gene:	DDX41 / 51428	HGNCID:	18674	Length:	622	Species:	Homo sapiens

Alignment Length:	461	Identity:	174/461 - (37%)
Similarity:	256/461 - (55%)	Gaps:	30/461 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 KNFYKPCDSVLARTVGETETFLTSNEITIKGDQVPTPSIEFEEGGFPDYVMNEIRKQGFAKPTAI 183
            |..:.|...||:.:....|.......|.::||.:|.|...|:|..||..::..::|:|...||.|
Human   143 KTSWTPPRYVLSMSEERHERVRKKYHILVEGDGIPPPIKSFKEMKFPAAILRGLKKKGIHHPTPI 207

  Fly   184 QAQGWPIAMSGRDLVGVAQTGSGKTLAYVLPAVVH-INNQPRL--ERGDGPIALVLAPTRELAQQ 245
            |.||.|..:||||::|:|.|||||||.:.||.::. :..:.||  .:.:||..|::.|:||||:|
Human   208 QIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQEKRLPFSKREGPYGLIICPSRELARQ 272

  Fly   246 IQQV------AIEFGSNTHVRNTCIFGGAPKGQQARDLERGVEIVIATPGRLIDFLERGTTSLKR 304
            ...:      .::..|:..:|.....||....:|...:..||.:::||||||:|.|::...||..
Human   273 THGILEYYCRLLQEDSSPLLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDI 337

  Fly   305 CTYLVLDEADRMLDMGFEPQIRKIMQQIRPDRQVLMWSATWPKEVRQLAEEFLNNYIQVNIGSLS 369
            |.||.|||||||:|||||..||.|....:..||.|::|||.||:::..|:..|...:.:|:|...
Human   338 CRYLALDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTINVGRAG 402

  Fly   370 LSANHNILQIVDVCDENEKLMKLIKLLTDISAENETKTIIFVETKKRVDEITRNISRQGWRACAI 434
             :|:.:::|.|:...|..|::.|::.|    .:.....:||.|.|..||.|...:..:|..|.||
Human   403 -AASLDVIQEVEYVKEEAKMVYLLECL----QKTPPPVLIFAEKKADVDAIHEYLLLKGVEAVAI 462

  Fly   435 HGDKSQQERDFVLSSFRNGRHSILVATDVAARGLDVDDVKFVINYDYPSNSEDYVHRIGRTGRSN 499
            ||.|.|:||...:.:||.|:..:|||||||::|||...::.|||||.|...|:|||||||||||.
Human   463 HGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFPAIQHVINYDMPEEIENYVHRIGRTGRSG 527

  Fly   500 NTGTAYTLFTHSNANKA------NDLIQVLREANQTINPKLMNMAMNGGYNKR---GGGMGGGYR 555
            |||.|.|..     |||      .||..:|.||.|.:.|.|  ..::.|....   ||..|..:.
Human   528 NTGIATTFI-----NKACDESVLMDLKALLLEAKQKVPPVL--QVLHCGDESMLDIGGERGCAFC 585

  Fly   556 GGNGYQ 561
            ||.|::
Human   586 GGLGHR 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10077	NP_001261491.1	PTZ00110	49..544	CDD:240273	168/439 (38%)
		DEADc	159..364	CDD:238167	84/213 (39%)
		HELICc	375..507	CDD:238034	58/131 (44%)
DDX41	NP_057306.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	52..84
		SrmB	153..>566	CDD:223587	164/424 (39%)
		Q motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00552	181..209		9/27 (33%)
		DEADc_DDX41	192..397	CDD:350709	80/204 (39%)
		DEAD box. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00541	344..347		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53695
OrthoDB	1	1.010	-	-		D183201at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.930