DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10077 and ddx5

DIOPT Version :9

Sequence 1:	NP_001261491.1	Gene:	CG10077 / 38756	FlyBaseID:	FBgn0035720	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_997777.2	Gene:	ddx5 / 322206	ZFINID:	ZDB-GENE-030131-925	Length:	617	Species:	Danio rerio

Alignment Length:	703	Identity:	366/703 - (52%)
Similarity:	439/703 - (62%)	Gaps:	117/703 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 PGFNGHGPANGGQRRMNGGGPSMGPGGPRNQDGFGGQNGG----QRSSNHGAHLPKIVWSEVNLT 115
            ||::..      .|..:.|..|.||  ||    |||...|    ::..|.|..|.|..|:...|.
Zfish     2 PGYSDR------DRGRDRGSYSSGP--PR----FGGSRNGPPPAKKFGNPGDRLRKKHWNLDELP 54

  Fly   116 PFRKNFYKPCDSVLARTVGETETFLTSNEITIKGDQVPTPSIEFEEGGFPDYVMNEIRKQGFAKP 180
            .|.||||:....|..|:..|.|.:..|.|||:||...|.|.::|.|..||.|||:.|.||.:..|
Zfish    55 KFEKNFYQENPDVARRSAQEVEHYRRSKEITVKGRDGPKPIVKFHEANFPKYVMDVITKQNWTDP 119

  Fly   181 TAIQAQGWPIAMSGRDLVGVAQTGSGKTLAYVLPAVVHINNQPRLERGDGPIALVLAPTRELAQQ 245
            |.|||||||:|:||:|:||:|||||||||:|:|||:||||:||.||.|||||.||||||||||||
Zfish   120 TPIQAQGWPVALSGKDMVGIAQTGSGKTLSYLLPAIVHINHQPFLEHGDGPICLVLAPTRELAQQ 184

  Fly   246 IQQVAIEFGSNTHVRNTCIFGGAPKGQQARDLERGVEIVIATPGRLIDFLERGTTSLKRCTYLVL 310
            :||||.|:|..:.:::|||:||||||.|.|||||||||.||||||||||||.|.|:|:|||||||
Zfish   185 VQQVAAEYGKASRIKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNLRRCTYLVL 249

  Fly   311 DEADRMLDMGFEPQIRKIMQQIRPDRQVLMWSATWPKEVRQLAEEFLNNYIQVNIGSLSLSANHN 375
            ||||||||||||||||||:.|||||||.||||||||||||||||:||..|||:|:|:|.||||||
Zfish   250 DEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKEYIQINVGALQLSANHN 314

  Fly   376 ILQIVDVCDENEKLMKLIKLLTDISAENETKTIIFVETKKRVDEITRNISRQGWRACAIHGDKSQ 440
            ||||||||::.||..|||:||.:|.:|.|.|||||||||:|.|::||.:.|.||.|..|||||:|
Zfish   315 ILQIVDVCNDGEKEDKLIRLLEEIMSEKENKTIIFVETKRRCDDLTRRMRRDGWPAMGIHGDKNQ 379

  Fly   441 QERDFVLSSFRNGRHSILVATDVAARGLDVDDVKFVINYDYPSNSEDYVHRIGRTGRSNNTGTAY 505
            ||||:||:.|:.|:..||:|||||:|||||:|||||||:|||:|||||:||||||.||..|||||
Zfish   380 QERDWVLNEFKYGKAPILIATDVASRGLDVEDVKFVINFDYPNNSEDYIHRIGRTARSQKTGTAY 444

  Fly   506 TLFTHSNANKANDLIQVLREANQTINPKLMNMAMNGGYNKRGGGMGGGYR--------------- 555
            |.||.:|..:|:||:.|||||||.|||||:.||.:.|...| ||.|||||
Zfish   445 TFFTPNNMKQAHDLVSVLREANQAINPKLIQMAEDRGGRSR-GGRGGGYRDDRRDRHSGSRRDFG 508

  Fly   556 --------GGNGYQGRNPQMGG-GYNGGNNYRNNNGPGATMNRNSFNGGSAGGPPRFDQKPRTSP 611
                    ||:.| |:....|. ..||.::|.|::.     :.:|||||..
Zfish   509 SYSQDNRSGGDSY-GQKKVFGNKTQNGSSSYNNSSS-----SSSSFNGGGY-------------- 553

  Fly   612 PNQGGQGGYRGQGGG-GYQGQQQQQQQQN-GGVPFSRFNPNAACFEPNKPQNGPGSGPPQAQHQQ 674
             |..|||.:..|.|| |.||.|.||...| |||                 |||....||...:.|
Zfish   554 -NNNGQGNFGNQSGGYGNQGYQNQQFPPNQGGV-----------------QNGMNHPPPFPFNPQ 600

  Fly   675 QQQAQAAQQQHLLPDASVQAAMTAANYGVDQKRSRFSPYNMNFANMPPPAMNQ 727
            |.                                   |..|.|. |.|||..|
Zfish   601 QM-----------------------------------PQTMQFP-MAPPAFPQ 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10077	NP_001261491.1	PTZ00110	49..544	CDD:240273	312/492 (63%)
		DEADc	159..364	CDD:238167	156/204 (76%)
		HELICc	375..507	CDD:238034	90/131 (69%)
ddx5	NP_997777.2	PRK01297	25..446	CDD:234938	279/420 (66%)
		DEADc	98..303	CDD:238167	156/204 (76%)
		HELICc	314..446	CDD:238034	90/131 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	293	1.000	Domainoid score	I1483
eggNOG	1	0.900	-	-		E2759_KOG0331
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6797
Inparanoid	1	1.050	653	1.000	Inparanoid score	I768
OMA	1	1.010	-	-		QHG53695
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000439
OrthoInspector	1	1.000	-	-		otm26026
orthoMCL	1	0.900	-	-		OOG6_100364
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R290
SonicParanoid	1	1.000	-	-		X504
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.760