DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10077 and ddx46

DIOPT Version :9

Sequence 1:	NP_001261491.1	Gene:	CG10077 / 38756	FlyBaseID:	FBgn0035720	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	XP_009294012.1	Gene:	ddx46 / 321948	ZFINID:	ZDB-GENE-030131-667	Length:	1035	Species:	Danio rerio

Alignment Length:	721	Identity:	219/721 - (30%)
Similarity:	360/721 - (49%)	Gaps:	111/721 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 EVNLTPFRKNFYKPCDSVLARTVGE--TETFLTSNEITIKGDQVPTPSIEFEEGGFPDYVMNEIR 173
            ::...|||||||..... |||...|  :|..|....|::||...|.|...:.:.|....|:|.::
Zfish   310 KIQYEPFRKNFYVEVPE-LARMSPEEVSEYRLELEGISVKGKGCPKPIKTWVQCGISMKVLNALK 373

  Fly   174 KQGFAKPTAIQAQGWPIAMSGRDLVGVAQTGSGKTLAYVLPAVVHINNQPRLERGDGPIALVLAP 238
            |..:.|||.||||..|..||||||:|:|:||||||:|::||...||.:|..:...:||:|:::.|
Zfish   374 KHNYEKPTPIQAQAIPAIMSGRDLIGIAKTGSGKTIAFLLPMFRHILDQRPVGEAEGPLAVIMTP 438

  Fly   239 TRELAQQIQQVAIEFGSNTHVRNTCIFGGAPKGQQARDLERGVEIVIATPGRLIDFLERG---TT 300
            |||||.||.:...:|..:..:|..|::||....:|..:|:||.||::.||||:||.|...   .|
Zfish   439 TRELALQITKECKKFSKSLALRVVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLGANNGRVT 503

  Fly   301 SLKRCTYLVLDEADRMLDMGFEPQIRKIMQQIRPDRQVLMWSATWPKEVRQLAEEFLNNYIQVNI 365
            :|:|.||:|:||||||.|||||||:.:|:..:|||||.:|:|||:|:.:..||...|:..::|.:
Zfish   504 NLRRVTYVVIDEADRMFDMGFEPQVMRIVDNVRPDRQTVMFSATFPRTMEALARRILSKPVEVQV 568

  Fly   366 GSLSLSANHNILQIVDVCDENEKLMKLIKLLTDISAENETKTIIFVETKKRVDEITRNISRQGWR 430
            |..|:..: ::.|.|.|.:|.:|.:||:::|...  :.:...||||:.::..|.:.:::.:..:.
Zfish   569 GGRSVVCS-DVEQHVIVIEEEKKFLKLLEILGHY--QEKGSVIIFVDKQEHADGLLKDLMKASYP 630

  Fly   431 ACAIHGDKSQQERDFVLSSFRNGRHSILVATDVAARGLDVDDVKFVINYDYPSNSEDYVHRIGRT 495
            ..::||...|.:||.:::.|:||...:||||.||||||||..:..|:||..|::.||||||.|||
Zfish   631 CMSLHGGIDQYDRDSIINDFKNGACRLLVATSVAARGLDVKQLILVVNYSCPNHYEDYVHRAGRT 695

  Fly   496 GRSNNTGTAYTLFTHSNANKANDLIQVLREANQTINPKLMNMAMNGGYNKRGGGMGGGYRGGNGY 560
            ||:.|.|.|||..|...|..:.|:::.|..:..::..:|..:..|  :.::....|...:..:|:
Zfish   696 GRAGNKGYAYTFITEGQARYSGDILKALELSGSSVPAELEQLWTN--FKEQQKAEGKIIKSSSGF 758

  Fly   561 QGR-------------------------------------NPQMGGGYNGGNNYRNNNGPGATMN 588
            .|:                                     :.|:...:|.....::.:.||
Zfish   759 SGKGFKFDETEHALANERKKLQKAALGLHDSDDEDTALDIDEQIESMFNSKKRVKDFSAPG---- 819

  Fly   589 RNSFNGGSAGGPPRFDQKPRTSPPNQGGQGGYRGQGGGGYQGQQ-------QQQQQQNGGVPFSR 646
              |.:.|||||       ...|.....|.|.......|..|..:       :.|.|:|.|.
Zfish   820 --SVSAGSAGG-------VSGSVSAVSGLGSLSTPSAGNIQKLEIAKKLALRIQAQKNLGA---- 871

  Fly   647 FNPNAACFEPNKPQNGPGSGPPQAQHQQQQQAQAAQQQHLLPDASVQAAMTAANYGVDQKRSRFS 711
                                  :||...||...|     :|...::.|...:|....:|:..:.:
Zfish   872 ----------------------EAQDVMQQATNA-----ILRGGTIIAPSVSAKTIAEQQAEKIN 909

  Fly   712 PYNMNFANMPPPAMNQQQAAAAQ--QQQQQQLQT---PQQQQQQQQMQQP-QAYGQYSSMSSSMA 770
            . .:|:..:......:|.|.||:  ::.:::|:.   ||..:.:...::. |..|:||.     |
Zfish   910 A-KLNYTPVEKLEEERQAAEAAETVKRYEEELEINDFPQTARWKVTSKEALQRIGEYSE-----A 968

  Fly   771 TVSLNG 776
            .:::.|
Zfish   969 AITIRG 974

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10077	NP_001261491.1	PTZ00110	49..544	CDD:240273	174/437 (40%)
		DEADc	159..364	CDD:238167	94/207 (45%)
		HELICc	375..507	CDD:238034	52/131 (40%)
ddx46	XP_009294012.1	SrmB	348..811	CDD:223587	165/467 (35%)
		DEADc	363..566	CDD:238167	94/202 (47%)
		HELICc	577..707	CDD:238034	52/131 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245118at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920