DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10077 and Ddx21

DIOPT Version :9

Sequence 1:	NP_001261491.1	Gene:	CG10077 / 38756	FlyBaseID:	FBgn0035720	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001032278.1	Gene:	Ddx21 / 317399	RGDID:	1307306	Length:	782	Species:	Rattus norvegicus

Alignment Length:	661	Identity:	179/661 - (27%)
Similarity:	282/661 - (42%)	Gaps:	180/661 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 KPCDSVLARTVGETETFLTSNEITIKGDQVPTPSIEFEEGGFPDYVMNE-----IRKQGFAKPTA 182
            || ||...:..||...  |..||          .:|.:||.|.::.::|     ::.:|......
  Rat   156 KP-DSSSTQAPGEESE--TEKEI----------PVEQKEGAFSNFPISEETVKLLKARGVNFLFP 207

  Fly   183 IQAQGWPIAMSGRDLVGVAQTGSGKTLAYVLPAVVHINN--QPRLERGDGPIALVLAPTRELAQQ 245
            |||:.:....||:||:..|:||:|||.::.:|.:..:..  |.| :||..|..||||||||||.|
  Rat   208 IQAKTFHHVYSGKDLIAQARTGTGKTFSFAIPLIEKLQGGLQER-KRGRAPQVLVLAPTRELANQ 271

  Fly   246 IQQVAIEFGSNT-HVRNTCIFGGAPKGQQARDLERGVEIVIATPGRLIDFLERGTTSLKRCTYLV 309
            :.:   :|...| .:...|.:||.|.|.|...:..|::|::.||||:.|.|:.|...|.:..::|
  Rat   272 VSK---DFSDITKKLSVACFYGGTPYGGQIERMRSGIDILVGTPGRIKDHLQNGKLDLTKLKHVV 333

  Fly   310 LDEADRMLDMGFEPQIRKIM-----QQIRPDRQVLMWSATWPKEVRQLAEEFL-NNYIQVN-IGS 367
            |||.|:||||||..|:.:|:     :....:.|.|::|||.|..|..:|:::: :.|.||: ||.
  Rat   334 LDEVDQMLDMGFADQVEEILCVAYKKDSEDNPQTLLFSATCPHWVFNVAKKYMKSTYEQVDLIGK 398

  Fly   368 LSLSANHNILQIVDVCDENEKLMKLIKLLTDISAENETKTIIFVETKKRVDEITRNIS-RQGWRA 431
            .:..|...:..:...|...|: ..:|..:..:.:.::.:||||.||||...|:::|.. :|.  |
  Rat   399 KTQKAAITVEHLAIKCHWTER-AAVIGDVIRVYSGHQGRTIIFCETKKDAQELSQNTCIKQD--A 460

  Fly   432 CAIHGDKSQQERDFVLSSFRNGRHSILVATDVAARGLDVDDVKFVINYDYPSNSEDYVHRIGRTG 496
            .::|||..|::|:..|..||||...:||||:|||||||:.:|..|:....|.:.|.|:||.||||
  Rat   461 QSLHGDIPQKQREITLKGFRNGNFGVLVATNVAARGLDIPEVDLVVQSCPPKDVESYIHRSGRTG 525

  Fly   497 RSNNTGTAYTLFTHSNANK---------------------------ANDLIQVL----------- 523
            |:..||.....:.|....:                           :.|.|::|
  Rat   526 RAGRTGVCICFYQHKEEYQLAQVEQKAGIKFKRIGVPSATEIIKASSKDAIRLLDSVPPTAIGHF 590

  Fly   524 -REANQTINPK-----------------------LMNMAM--------------NGGY------N 544
             :.|.:.|..|                       |:|...              |..|      .
  Rat   591 KQSAEKLIEEKGAVEALAAALAHISGATSVDQRSLINSQAGFVTMILRCSVEMPNISYAWKELKE 655

  Fly   545 KRGGGMGGGYRGGNGYQGR--------------------------------NPQMGG---GYNGG 574
            :.|..:....:|....:|:                                .|::.|   ||.||
  Rat   656 QLGESIDAKVKGMVFLKGKLGVCFDVRTEAVTEIKEKWHDSRRWQLTVATEQPELEGPPEGYRGG 720

  Fly   575 NNYRNNNGPGATMNRNSFNGGSAGGPPRFDQKPRTSPPNQGGQGGYRGQGGGGYQGQQQQQQQQN 639
            ...|:.       :|.||.|                  .:||...:||||..|  |.:..:.|:.
  Rat   721 RGQRDG-------SRGSFRG------------------QRGGSRNFRGQGQRG--GSRNFRGQRP 758

  Fly   640 GGVPFSRFNPN 650
            ||...|..:||
  Rat   759 GGGNKSNRSPN 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10077	NP_001261491.1	PTZ00110	49..544	CDD:240273	151/518 (29%)
		DEADc	159..364	CDD:238167	76/218 (35%)
		HELICc	375..507	CDD:238034	50/132 (38%)
Ddx21	NP_001032278.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..184		12/40 (30%)
		BASP1	7..165	CDD:283191	4/9 (44%)
		PRK01297	112..557	CDD:234938	141/420 (34%)
		Q motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00552	182..210		5/27 (19%)
		DEADc	184..391	CDD:238167	72/210 (34%)
		DEAD box. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00541	335..338		2/2 (100%)
		HELICc	425..534	CDD:238034	47/110 (43%)
		GUCT_RHII_Gualpha_beta	613..705	CDD:240593	7/91 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	704..782		25/93 (27%)
		MPLKIP	<707..>780	CDD:292140	25/90 (28%)
		AdoMet_MTases	716..>765	CDD:302624	20/75 (27%)
		3 X 5 AA repeats	720..747		12/51 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0331
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53695
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820