DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10077 and Ddx17

DIOPT Version :9

Sequence 1:	NP_001261491.1	Gene:	CG10077 / 38756	FlyBaseID:	FBgn0035720	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001359065.1	Gene:	Ddx17 / 315133	RGDID:	1304945	Length:	652	Species:	Rattus norvegicus

Alignment Length:	781	Identity:	364/781 - (46%)
Similarity:	433/781 - (55%)	Gaps:	170/781 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 MNGGGPSMGPGGPRNQD----GFGGQNGG----QRSSNHGAHLPKIVWSEVNLTPFRKNFYKPCD 126
            |.|||     .|.|::|    |||.:.|.    ::..|.|..|.|..|....|..|.||||....
  Rat     1 MRGGG-----FGDRDRDRDRGGFGARGGSGLPPKKFGNPGERLRKKKWDLSELPKFEKNFYVEHP 60

  Fly   127 SVLARTVGETETFLTSNEITIK-GDQVPTPSIEFEEGGFPDYVMNEIRKQGFAKPTAIQAQGWPI 190
            .|...|..|.:......|||:: ||..|.|...|....||.|||:.:..|.|.:||.||.||:|:
  Rat    61 EVARLTPYEVDELRRKKEITVRGGDVCPKPVFAFHHANFPQYVMDVLMDQHFTEPTPIQCQGFPL 125

  Fly   191 AMSGRDLVGVAQTGSGKTLAYVLPAVVHINNQPRLERGDGPIALVLAPTRELAQQIQQVAIEFGS 255
            |:||||:||:|||||||||||:|||:||||:||.||||||||.||||||||||||:||||.::|.
  Rat   126 ALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYLERGDGPICLVLAPTRELAQQVQQVADDYGK 190

  Fly   256 NTHVRNTCIFGGAPKGQQARDLERGVEIVIATPGRLIDFLERGTTSLKRCTYLVLDEADRMLDMG 320
            .:.:::|||:||||||.|.|||||||||.||||||||||||.|.|:|:|||||||||||||||||
  Rat   191 CSRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLESGKTNLRRCTYLVLDEADRMLDMG 255

  Fly   321 FEPQIRKIMQQIRPDRQVLMWSATWPKEVRQLAEEFLNNYIQVNIGSLSLSANHNILQIVDVCDE 385
            ||||||||:.|||||||.||||||||||||||||:||.:|.|:|:|:|.||||||||||||||.|
  Rat   256 FEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRDYTQINVGNLELSANHNILQIVDVCME 320

  Fly   386 NEKLMKLIKLLTDISAENETKTIIFVETKKRVDEITRNISRQGWRACAIHGDKSQQERDFVLSSF 450
            :||..|||:|:.:|.||.|.|||||||||:|.|::||.:.|.||.|..|||||||.|||:||:.|
  Rat   321 SEKDHKLIQLMEEIMAEKENKTIIFVETKRRCDDLTRRMRRDGWPAMCIHGDKSQPERDWVLNEF 385

  Fly   451 RNGRHSILVATDVAARGLDVDDVKFVINYDYPSNSEDYVHRIGRTGRSNNTGTAYTLFTHSNANK 515
            |:|:..||:|||||:|||||:|||||||||||::|||||||||||.||.|.|||||.||..|..:
  Rat   386 RSGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYVHRIGRTARSTNKGTAYTFFTPGNLKQ 450

  Fly   516 ANDLIQVLREANQTINPKLMNMAMNGGYNKRGGGMGGGYRGGNGYQ----GRNPQM--------- 567
            |.:||:||.||||.||||||.:.     :.||||.|||..|.:.|:    ..||.:
  Rat   451 ARELIKVLEEANQAINPKLMQLV-----DHRGGGGGGGKGGRSRYRTTSSANNPNLMYQDECDRR 510

  Fly   568 -----GGGYNGGNNYRNNNGPGATMNRNSFNGGSAGGPPRFDQKPRTSPPNQGGQGGYRGQGGGG 627
                 .||.....:||:.:                       :..|.|..|           |.|
  Rat   511 LRGVKDGGRRDSTSYRDRS-----------------------ETDRASYAN-----------GSG 541

  Fly   628 YQGQQQQQQQQNGGVPFSRFNPNAACFEPNKPQNGPGSGPPQAQHQQQQQAQAAQQQHLLPDASV 692
            |            |.|.|.|.                             |||.|..:      .
  Rat   542 Y------------GSPNSAFG-----------------------------AQAGQYTY------A 559

  Fly   693 QAAMTAANYGVDQKRSRFSPYN-MNFANMPPPAMNQQQAAAAQQQQQQQL-------QTPQQQQQ 749
            |....||.||.       |.|. ..:|.....|.:......:.|...||.       |.||....
  Rat   560 QGTYGAAAYGT-------SGYTAQEYAAGTYGASSTTSTGRSSQSSSQQFSGIGRSGQQPQPLMS 617

  Fly   750 QQQMQQPQAYGQYSSMSSSMATVSLNGGAAAVASSYRAPYAVPTQAAPYMMANGGDIFAYPPPPL 814
            ||..|.|.|                                  |....||   |...:.|||||.
  Rat   618 QQFAQPPGA----------------------------------TNMIGYM---GQTAYQYPPPPP 645

  Fly   815 P 815
            |
  Rat   646 P 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10077	NP_001261491.1	PTZ00110	49..544	CDD:240273	305/482 (63%)
		DEADc	159..364	CDD:238167	153/204 (75%)
		HELICc	375..507	CDD:238034	93/131 (71%)
Ddx17	NP_001359065.1	PTZ00110	32..502	CDD:240273	305/474 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353878
Domainoid	1	1.000	287	1.000	Domainoid score	I1518
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	616	1.000	Inparanoid score	I857
OMA	1	1.010	-	-		QHG53695
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000439
OrthoInspector	1	1.000	-	-		otm46006
orthoMCL	1	0.900	-	-		OOG6_100364
Panther	1	1.100	-	-	O	PTHR47958
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X504
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.900