DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10077 and ddx-46

DIOPT Version :9

Sequence 1:	NP_001261491.1	Gene:	CG10077 / 38756	FlyBaseID:	FBgn0035720	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001033411.1	Gene:	ddx-46 / 176943	WormBaseID:	WBGene00018776	Length:	970	Species:	Caenorhabditis elegans

Alignment Length:	681	Identity:	223/681 - (32%)
Similarity:	348/681 - (51%)	Gaps:	74/681 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 DGFGGQNGGQRSSNHGAHLPKIVWSEVNLTPFRKNFYKPCDSVLARTVGETETFLTS-NEITIKG 149
            |.|..:.......:.|..|.:...|:|....|:||||...:.:...|..|.:.:... :.||:||
Worm   232 DDFDIETAAASLCHKGRMLAQTDHSKVYYRKFKKNFYIETEEIRRMTKAEVKAYREELDSITVKG 296

  Fly   150 DQVPTPSIEFEEGGFPDYVMNEIRKQGFAKPTAIQAQGWPIAMSGRDLVGVAQTGSGKTLAYVLP 214
            ...|.|...:.:.|....:||.::|..::|||:||||..|..|||||::|:|:||||||||::||
Worm   297 IDCPKPIKTWAQCGVNLKMMNVLKKFEYSKPTSIQAQAIPSIMSGRDVIGIAKTGSGKTLAFLLP 361

  Fly   215 AVVHINNQPRLERGDGPIALVLAPTRELAQQIQQVAIEFGSNTHVRNTCIFGGAPKGQQARDLER 279
            ...||.:||.||.||||||::||||||||.|..:.|.:|.....::..|.:||....:|..||:|
Worm   362 MFRHILDQPELEEGDGPIAVILAPTRELAMQTYKEANKFAKPLGLKVACTYGGVGISEQIADLKR 426

  Fly   280 GVEIVIATPGRLIDFLERGT---TSLKRCTYLVLDEADRMLDMGFEPQIRKIMQQIRPDRQVLMW 341
            |.|||:.||||:||.|...:   |:|:|.|||||||||||.|.||||||.|::..||||:|.:::
Worm   427 GAEIVVCTPGRMIDVLAANSGKVTNLRRVTYLVLDEADRMFDKGFEPQIMKVVNNIRPDKQTVLF 491

  Fly   342 SATWPKEVRQLAEEFLNNYIQVNIGSLSLSANHNILQIVDVCDENEKLMKLIKLLTDISAENETK 406
            |||:|:.:..||.:.|:..:::.:|..|:..: :|.|...:|.|::|.:||::||.  ....|..
Worm   492 SATFPRHMEALARKVLDKPVEILVGGKSVVCS-DITQNAVICAEHQKFLKLLELLG--MYYEEGS 553

  Fly   407 TIIFVETKKRVDEITRNISRQGWRACA-IHGDKSQQERDFVLSSFRNGRHSILVATDVAARGLDV 470
            :|:||:.:::.|:|...:.|.|:.:.| :||...|.:||..::.|:.|...:||||.||||||||
Worm   554 SIVFVDKQEKADDIVDQLMRTGYNSVAPLHGGIDQHDRDSSIADFKTGVIKVLVATSVAARGLDV 618

  Fly   471 DDVKFVINYDYPSNSEDYVHRIGRTGRSNNTGTAYTLFTHSNANK-ANDLIQVLREANQTINPKL 534
            .::..|:|||.|::.||||||:|||||:...|.|||.....:..| |.::.:....|.  ..|..
Worm   619 KNLILVVNYDCPNHYEDYVHRVGRTGRAGRKGYAYTFVLPEHQEKMAGEICRAFETAG--CKPPA 681

  Fly   535 MNMAMNGGYNKRGGGMGGGYRGGNGYQGRNPQMGGGYNGGNNYRNNNGPG-ATMNRNSF----NG 594
            ...||   :.:        ::.....:|:..::||....|:.|:.:.|.. |..|:...    :|
Worm   682 DLKAM---FER--------FKSEMAAEGKEVKLGGKGFEGSGYKYDEGEAEADANKKRMTRLVHG 735

  Fly   595 GSAGGPPRFD-----------------QKPRTSPPNQGGQGGYRGQGGGGYQGQQQQQQQQNGGV 642
            ..|||....|                 .||::..|: ...|..:.....|.:..|.:.:.:....
Worm   736 MEAGGDDDDDLEEQLSSMIKTKRRVVHGKPQSEKPS-SSSGNAKNDREAGKRADQAKLKAEELST 799

  Fly   643 PFSRFNPNAACFEPNKPQNGPGSGPPQAQHQQQQQAQAAQQQHLLPDASVQAAMTAANYGVDQKR 707
            ..                    .|..|.....::.|.....:.:|..|.|..|..:|.....:|.
Worm   800 RL--------------------KGASQVVQPVEKTAAQLTAEAVLRGAEVAPAQMSAAMLAKEKA 844

  Fly   708 SRFSPYNMNFANMPPPAMNQQQAAAAQQQQQ 738
            :|.:. .:|:..        .:||..|||::
Worm   845 NRLNE-KLNYLG--------GEAAPTQQQEE 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10077	NP_001261491.1	PTZ00110	49..544	CDD:240273	188/463 (41%)
		DEADc	159..364	CDD:238167	104/207 (50%)
		HELICc	375..507	CDD:238034	56/132 (42%)
ddx-46	NP_001033411.1	SrmB	276..793	CDD:223587	196/533 (37%)
		DEADc	316..514	CDD:238167	103/197 (52%)
		HELICc	534..655	CDD:238034	53/122 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245118at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920