Protein Alignment CG10077 and glh-2

DIOPT Version :10

• Sequence 1: NP_648062.2
• Gene: CG10077 / 38756
• FlyBaseID: FBgn0035720
• Length: 818
• Species: Drosophila melanogaster
• Sequence 2: NP_491876.1
• Gene: glh-2 / 172361
• WormBaseID: WBGene00001599
• Length: 974
• Species: Caenorhabditis elegans
• Alignment Length: 678
• Identity: 207/678 - (30%)
• Similarity: 295/678 - (43%)
• Gaps: 134/678 - (19%)

  Fly     2 NMYNGQMNAFGGGGGGGAG---GLAGGMVPNR----------MGGGAPGGGPGGAGMFQ------ 47
            |.:.|..:.||||.|||.|   ||..|.....          .||.:.|.|.||.|..:
 Worm   308 NGFTGGSSGFGGGNGGGTGFDSGLTNGFGSGNNGESGFGSGGFGGNSNGFGSGGGGQDRGERNNN 372

  Fly    48 ---------RNRSAP---------------YPGFNGHGPANGGQRRMNGGGPSMGPGGPRNQDGF 88
                     |:...|               .||.|........:.|....|.:.|.|| .|..||
 Worm   373 CFNCQQPGHRSNDCPEPKKEREPRVCYNCQQPGHNSRDCPEERKPREGRNGFTSGFGG-GNDGGF 436

  Fly    89 GGQNG----------------------------------------GQRSS--------NHGA--H 103
            ||.|.                                        |.||:        ..||  .
 Worm   437 GGGNAEGFGNNEERGPMKCFNCKGEGHRSAECPEPPRGCFNCGEQGHRSNECPNPAKPREGAEGE 501

  Fly   104 LPKIVWSEV--NLTPFRKNFYKPCDSVLARTVGETETFLTSNEITIKGDQVPTPSIEFEEGGFPD 166
            .||..:..|  |:... .|..|..:.::.....:.|..:||::..:......|    |.|....:
 Worm   502 GPKATYVPVEDNMEEV-FNMQKISEGLMFNKFFDAEVKITSDKKPVGVKTCKT----FSEANLGE 561

  Fly   167 YVMNEIRKQGFAKPTAIQAQGWPIAMSGRDLVGVAQTGSGKTLAYVLPAVVHINNQPRLE-RGDG 230
            .:...:...|:.|.|.||....|:...|.|::..||||||||.|::||.:..:.::..|. .|:|
 Worm   562 TMKKNVAHAGYTKTTPIQQYTLPLIHQGHDIMACAQTGSGKTAAFLLPIMARLIDENDLNTAGEG 626

  Fly   231 ---PIALVLAPTRELAQQIQQVAIEFGSNTHVRNTCIFGGAPKGQQARDLERGVEIVIATPGRLI 292
               |..::|.|||||..||.....:|...|.:....::||...|.....:|:|..|::.|.||:.
 Worm   627 GCYPRCIILTPTRELTDQIYNEGRKFAYQTMMEIRPVYGGLAVGYNKGQIEKGATIIVGTVGRIK 691

  Fly   293 DFLERGTTSLKRCTYLVLDEADRMLD-MGFEPQIRKIM----QQIRPDRQVLMWSATWPKEVRQL 352
            .|.|.||..|.:|.:.||||||||:| |||...|..|:    ...:.:||.||:|||:|..|::.
 Worm   692 HFCEEGTIKLDKCRFFVLDEADRMIDAMGFGTDIDTIVNYESMPKKENRQTLMFSATFPDSVQEA 756

  Fly   353 AEEFL-NNYIQVNIGSLSLSANHNILQIVDVCDENEKLMKLIKLL--------TDISAENET-KT 407
            |...| ..||.:.|..:. :||..:||..:.||.:||..||:::|        |:.::|..| ||
 Worm   757 ARNHLKEGYIMLAIDKIG-AANKCVLQEFEKCDRSEKKDKLLEILGIDIDSYTTEKNSEVYTKKT 820

  Fly   408 IIFVETKKRVDEITRNISRQGWRACAIHGDKSQQERDFVLSSFRNGRHSILVATDVAARGLDVDD 472
            |:||..:...|.:...:|.....|..|||.:.|:||...|..||||...:|:||.||.||||:..
 Worm   821 IVFVSQRAMADTLASILSSAQVPAITIHGAREQRERSEALRQFRNGSKPVLIATAVAERGLDIKG 885

  Fly   473 VKFVINYDYPSNSEDYVHRIGRTGRSNNTGTAYTLFTHSNANKANDLIQVLREANQTINPKLMNM 537
            |..|||||.|.|.:||:||||||||..|.|.| |.|...:.|..::|::||.:|:|.: |:.|.
 Worm   886 VDHVINYDMPDNIDDYIHRIGRTGRVGNAGRA-TSFISEDCNLLSELVRVLSDADQLV-PEWMQ- 947

  Fly   538 AMNGGYNKRGGGMGGGYRGGNGYQGRNP 565
                      |..||.:....|::...|
 Worm   948 ----------GASGGNFGASFGFESSVP 965

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10077	NP_648062.2	DEAD-like_helicase_N	49..544	CDD:475120	181/580 (31%)
glh-2	NP_491876.1	Keratin_2_head	73..>177	CDD:465068
		PTZ00368	<250..300	CDD:173561
		PTZ00368	373..508	CDD:173561	23/135 (17%)
		SrmB	553..924	CDD:440279	144/376 (38%)