Protein Alignment CG10077 and DDX5

DIOPT Version :10

• Sequence 1: NP_648062.2
• Gene: CG10077 / 38756
• FlyBaseID: FBgn0035720
• Length: 818
• Species: Drosophila melanogaster
• Sequence 2: NP_004387.1
• Gene: DDX5 / 1655
• HGNCID: 2746
• Length: 614
• Species: Homo sapiens
• Alignment Length: 592
• Identity: 333/592 - (56%)
• Similarity: 403/592 - (68%)
• Gaps: 42/592 - (7%)

  Fly    74 GPSMGPGGPRNQDGFGGQN----GGQRSSNHGAHLPKIVWSEVNLTPFRKNFYKPCDSVLARTVG 134
            |...|.|.||    |||..    .|::..|.|..|.|..|:...|..|.||||:....:..||..
Human    11 GRDRGFGAPR----FGGSRAGPLSGKKFGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQ 71

  Fly   135 ETETFLTSNEITIKGDQVPTPSIEFEEGGFPDYVMNEIRKQGFAKPTAIQAQGWPIAMSGRDLVG 199
            |.||:..|.|||::|...|.|.:.|.|..||..||:.|.:|.|.:||||||||||:|:||.|:||
Human    72 EVETYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVG 136

  Fly   200 VAQTGSGKTLAYVLPAVVHINNQPRLERGDGPIALVLAPTRELAQQIQQVAIEFGSNTHVRNTCI 264
            ||||||||||:|:|||:||||:||.||||||||.||||||||||||:||||.|:.....:::|||
Human   137 VAQTGSGKTLSYLLPAIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCI 201

  Fly   265 FGGAPKGQQARDLERGVEIVIATPGRLIDFLERGTTSLKRCTYLVLDEADRMLDMGFEPQIRKIM 329
            :||||||.|.|||||||||.||||||||||||.|.|:|:|.|||||||||||||||||||||||:
Human   202 YGGAPKGPQIRDLERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIV 266

  Fly   330 QQIRPDRQVLMWSATWPKEVRQLAEEFLNNYIQVNIGSLSLSANHNILQIVDVCDENEKLMKLIK 394
            .|||||||.||||||||||||||||:||.:||.:|||:|.||||||||||||||.:.||..|||:
Human   267 DQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIR 331

  Fly   395 LLTDISAENETKTIIFVETKKRVDEITRNISRQGWRACAIHGDKSQQERDFVLSSFRNGRHSILV 459
            |:.:|.:|.|.|||:|||||:|.||:||.:.|.||.|..|||||||||||:||:.|::|:..||:
Human   332 LMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILI 396

  Fly   460 ATDVAARGLDVDDVKFVINYDYPSNSEDYVHRIGRTGRSNNTGTAYTLFTHSNANKANDLIQVLR 524
            |||||:|||||:|||||||||||::||||:||||||.||..||||||.||.:|..:.:|||.|||
Human   397 ATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLR 461

  Fly   525 EANQTINPKLMNMAMNGGYNKRGGGMGGGYRGGNGYQGRNPQMGGGYNGGNNYRN----NNGPGA 585
            ||||.|||||:.:.     ..||.|...| |||.....|:....|...|.|.:|:    :.|..:
Human   462 EANQAINPKLLQLV-----EDRGSGRSRG-RGGMKDDRRDRYSAGKRGGFNTFRDRENYDRGYSS 520

  Fly   586 TMNRN-------------SFNGGSAGGPPRFDQKPRTSPPNQGGQGGYR-GQGGGGYQGQQQQQQ 636
            .:.|:             ::..||.|          ::..:.|.|..:| |...|.||......|
Human   521 LLKRDFGAKTQNGVYSAANYTNGSFG----------SNFVSAGIQTSFRTGNPTGTYQNGYDSTQ 575

  Fly   637 QQNGGVP 643
            |....||
Human   576 QYGSNVP 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10077	NP_648062.2	DEAD-like_helicase_N	49..544	CDD:475120	305/473 (64%)
DDX5	NP_004387.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..39		10/31 (32%)
		DEAD-like_helicase_N	6..507	CDD:475120	315/505 (62%)
		Q motif	94..122		13/27 (48%)
		DEAD box	248..251		2/2 (100%)
		Transactivation domain	477..614		28/117 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	477..504		9/27 (33%)
		P68HR	498..532	CDD:429808	6/33 (18%)
		P68HR	551..583	CDD:429808	11/32 (34%)