DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10077 and Ddx3x

DIOPT Version :9

Sequence 1:NP_001261491.1 Gene:CG10077 / 38756 FlyBaseID:FBgn0035720 Length:818 Species:Drosophila melanogaster
Sequence 2:NP_034158.1 Gene:Ddx3x / 13205 MGIID:103064 Length:662 Species:Mus musculus


Alignment Length:623 Identity:235/623 - (37%)
Similarity:317/623 - (50%) Gaps:101/623 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 GPGGAGMFQRNRSAPYPGFNGHGPANGGQRRMNGG-------------GPSMGPGGPRNQDGFGG 90
            |.|..|.|.......|.|..|.|..:|..:...||             ...:.|.....|:.|.|
Mouse    89 GSGSRGRFDDRGRGDYDGIGGRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSG 153

  Fly    91 QNGGQRSSNHGAHLPKIVWSEVNLTPFRKNFYKPCDSVLARTVGETETFLTSNEITIKGDQVPTP 155
            .|.|                        .||.|..|..:..|                |:..| |
Mouse   154 GNTG------------------------INFEKYDDIPVEAT----------------GNNCP-P 177

  Fly   156 SIE-FEEGGFPDYVMNEIRKQGFAKPTAIQAQGWPIAMSGRDLVGVAQTGSGKTLAYVLPAVVHI 219
            .|| |.:....:.:|..|....:.:||.:|....||....|||:..||||||||.|::||.:..|
Mouse   178 HIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQI 242

  Fly   220 -------------NNQPRLERGDGPIALVLAPTRELAQQIQQVAIEFGSNTHVRNTCIFGGAPKG 271
                         .|.....|...||:||||||||||.||.:.|.:|...:.||...::|||..|
Mouse   243 YADGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGAEIG 307

  Fly   272 QQARDLERGVEIVIATPGRLIDFLERGTTSLKRCTYLVLDEADRMLDMGFEPQIRKIMQQ--IRP 334
            ||.||||||..:::||||||:|.:|||...|..|.||||||||||||||||||||:|::|  :.|
Mouse   308 QQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPP 372

  Fly   335 D--RQVLMWSATWPKEVRQLAEEFLNNYIQVNIGSLSLSANHNILQIVDVCDENEKLMKLIKLLT 397
            .  |..:|:|||:|||::.||.:||:.||.:.:|.:. |.:.||.|.|...:|.:|...|:.||.
Mouse   373 KGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVG-STSENITQKVVWVEEIDKRSFLLDLLN 436

  Fly   398 DISAENETKTIIFVETKKRVDEITRNISRQGWRACAIHGDKSQQERDFVLSSFRNGRHSILVATD 462
              :...::.|::||||||..|.:...:..:|:...:||||:||::|:..|..||:|:..|||||.
Mouse   437 --ATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATA 499

  Fly   463 VAARGLDVDDVKFVINYDYPSNSEDYVHRIGRTGRSNNTGTAYTLFTHSNANKANDLIQVLREAN 527
            |||||||:.:||.|||:|.||:.|:||||||||||..|.|.|.:.|...|.|...||:.:|.||.
Mouse   500 VAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAK 564

  Fly   528 QTINPKLMNMAMNGGYNKRGGGMGGGYRGGNGYQGRNPQMGGGYNGGNNYRNNNGPGATMNRNSF 592
            |.:...|.|||....|.       |..||    :.::.:..||: |..:||.::|..:    :||
Mouse   565 QEVPSWLENMAFEHHYK-------GSSRG----RSKSSRFSGGF-GARDYRQSSGASS----SSF 613

  Fly   593 NGGSAGGPPRFDQKPRTSPPNQGGQGGYRGQGGGGYQG 630
            :...|.          :|....||.||.||.|||||.|
Mouse   614 SSSRAS----------SSRSGGGGHGGSRGFGGGGYGG 641

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10077NP_001261491.1 PTZ00110 49..544 CDD:240273 205/525 (39%)
DEADc 159..364 CDD:238167 104/221 (47%)
HELICc 375..507 CDD:238034 63/131 (48%)
Ddx3xNP_034158.1 Required for TBK1 and IKBKE-dependent IFNB1 activation. /evidence=ECO:0000250|UniProtKB:O00571 2..139 11/49 (22%)
Nuclear export signal. /evidence=ECO:0000250|UniProtKB:O00571 12..21
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 19..144 12/54 (22%)
Interaction with EIF4E. /evidence=ECO:0000250|UniProtKB:O00571 38..44
PTZ00110 57..580 CDD:240273 209/534 (39%)
eIF-4B 80..>172 CDD:283846 22/122 (18%)
Interaction with GSK3B. /evidence=ECO:0000250|UniProtKB:O00571 100..662 231/612 (38%)
Interaction with IKBKE. /evidence=ECO:0000250|UniProtKB:O00571 100..110 2/9 (22%)
Interaction with CHUK. /evidence=ECO:0000250|UniProtKB:O00571 139..172 11/72 (15%)
Q motif 180..208 6/27 (22%)
DEADc 182..404 CDD:238167 104/221 (47%)
Involved in stimulation of ATPase activity by DNA and RNA, nucleic acid binding and unwinding. /evidence=ECO:0000250|UniProtKB:O00571 250..259 1/8 (13%)
DEAD box 347..350 2/2 (100%)
Helicase_C 426..536 CDD:278689 55/111 (50%)
Interaction with NXF1. /evidence=ECO:0000250|UniProtKB:O00571 536..661 42/132 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 601..633 11/45 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53695
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
43.880

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