DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10077 and ddx42

DIOPT Version :9

Sequence 1:	NP_001261491.1	Gene:	CG10077 / 38756	FlyBaseID:	FBgn0035720	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	XP_002935570.1	Gene:	ddx42 / 100135374	XenbaseID:	XB-GENE-972670	Length:	943	Species:	Xenopus tropicalis

Alignment Length:	539	Identity:	208/539 - (38%)
Similarity:	304/539 - (56%)	Gaps:	35/539 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 LPKIVWSEVNLTPFRKNFYKPCDSVLARTVGETETFLTSNEITIKGDQVPTPSIEFEEGGFPDYV 168
            ||.|..:|:..|||.||||:..:.:.::|..:.........:.:.|...|.....|...||.:.:
Frog   198 LPPIDHTEIEYTPFEKNFYEEHEEITSQTPQQITELRHKLNLRVSGAAPPRLCSSFAHFGFDEQL 262

  Fly   169 MNEIRKQGFAKPTAIQAQGWPIAMSGRDLVGVAQTGSGKTLAYVLPAVVHINNQPRLERGDGPIA 233
            |::|||..:.:||.||.||.|:|:||||::|:|:||||||.|::.|.:|||.:|..|:.||||||
Frog   263 MHQIRKSEYTQPTPIQCQGVPVALSGRDMIGIAKTGSGKTAAFIWPILVHIMDQKELQPGDGPIA 327

  Fly   234 LVLAPTRELAQQIQQVAIEFGSNTHVRNTCIFGGAPKGQQARDLERGVEIVIATPGRLIDFLERG 298
            :::.|||||.|||......||...::|:..::||....:||:.|:.|.|||:.|||||||.:::.
Frog   328 VIVCPTRELCQQIHSECKRFGKAYNLRSVAVYGGGSMWEQAKALQEGAEIVVCTPGRLIDHVKKK 392

  Fly   299 TTSLKRCTYLVLDEADRMLDMGFEPQIRKIMQQIRPDRQVLMWSATWPKEVRQLAEEFLNNYIQV 363
            .|:|:|.||||.||||||.|||||.|:|.|...:|||||.|::|||:.|::.:||.:.|.:.|:|
Frog   393 ATNLQRVTYLVFDEADRMFDMGFEYQVRSIANHVRPDRQTLLFSATFRKKIEKLARDILVDPIRV 457

  Fly   364 NIGSLSLSANHNILQIVDVCDEN-EKLMKLIKLLTDISAENETKTIIFVETKKRVDEITRNISRQ 427
            ..|.:. .||.:|.|:|::.... ||...|.:.|.:.::..  ..:|||..|...:|:..|:.:.
Frog   458 VQGDIG-EANEDITQVVEILPSGPEKWTWLTRRLVEFTSTG--SVLIFVTKKANAEELANNLRQD 519

  Fly   428 GWRACAIHGDKSQQERDFVLSSFRNGRHSILVATDVAARGLDVDDVKFVINYDYPSNSEDYVHRI 492
            ......:|||..|.||:.|:|.|:.....:||||||||||||:..:|.|||||...:.:.:.|||
Frog   520 DHPLGLLHGDMDQSERNKVISDFKKKSIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRI 584

  Fly   493 GRTGRSNNTGTAYTLFTHSNANKANDLIQVLREANQTINPKLMNMAMNGGYNKRG---------- 547
            |||||:...|.|:||.|..::|.|.||::.|..|||.::.:|:::||...:.::.
Frog   585 GRTGRAGEKGVAHTLLTPKDSNFAGDLVRNLEGANQYVSKELLDLAMQNSWFRKSRFKAGKGKKL 649

  Fly   548 --GGMGGGYRGGNGYQGRNPQMGGGYNGGNNYRNNNGPGATMN--------------RNSFNGGS 596
              ||.|.|||...|........|.|.|..:||......|..|.              :|.|...|
Frog   650 NIGGGGLGYRERPGLGAETSDRGVGGNVMSNYEAFKPTGGAMGDRLSAMKAAFQSQYKNHFVAAS 714

  Fly   597 AGGPPRFDQKPRTSPPNQG 615
            |.     .||..||..|.|
Frog   715 AS-----TQKTGTSSINSG 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10077	NP_001261491.1	PTZ00110	49..544	CDD:240273	184/440 (42%)
		DEADc	159..364	CDD:238167	102/204 (50%)
		HELICc	375..507	CDD:238034	50/132 (38%)
ddx42	XP_002935570.1	PTZ00110	196..650	CDD:240273	184/454 (41%)
ddx42	XP_002935570.1	PRK12678	733..>940	CDD:237171
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245118at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920