DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14820 and cpa2

DIOPT Version :9

Sequence 1:	NP_648060.1	Gene:	CG14820 / 38754	FlyBaseID:	FBgn0035718	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001003446.2	Gene:	cpa2 / 445052	ZFINID:	ZDB-GENE-040801-182	Length:	422	Species:	Danio rerio

Alignment Length:	410	Identity:	129/410 - (31%)
Similarity:	222/410 - (54%)	Gaps:	25/410 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVVGLFGLARSVE-QVRYDNYKVYNVRIDDLEQFKLLHTQERSLKLSSWREARHLGESSDIMLPP 70
            |.:.:|.|..:|. :..::..:|..:..:..:..::|...|:...|..|..........|:.:|.
Zfish     3 LCIAVFVLLVAVHCEELFNGDQVLRIHAESKDHIQVLKELEKDSGLDFWTHGFSTERPVDVRVPH 67

  Fly    71 EYQKTFESLLTKHNFTYNLKIDNVQTHIDAQRPK-------QRIT-SMEWTQFHTLEEIYAWLDV 127
            ......:..|.::|.::::.|:|||..:|.:|.:       :|.| |..:..:|.|:.||:::|.
Zfish    68 ASLYAVKDFLKENNISFSVMINNVQELLDRERAEMVSNTEMERNTKSFNFAAYHDLDTIYSFMDT 132

  Fly   128 IEDRYPDIVTPFTIGNSYEGRPIRGVKISY-KEGNPAVFIESNIHAREWITSATITYFIDELLV- 190
            :...:.::::...||::||.||:..:|.|. .|..||::|::.||||||::.|:..:..|.:..
Zfish   133 LVASHSNLISKVKIGSTYENRPMYVLKFSTGGENKPAIWIDAGIHAREWVSHASAVWIADRIATD 197

  Fly   191 -PRNPAV-RDIAQNVDWYIIPVLNTDGFAYSH----EVERLWRKSR-LPSDPTGECIGTDLNRNF 248
             ..|.|: |::...:|.|::.|.|.||:.:||    ...||||||| :.|:|  .|.|.||||||
Zfish   198 FKENRALARNVLSKMDIYLMIVANPDGYVFSHLTVRPFHRLWRKSRSVTSNP--NCPGVDLNRNF 260

  Fly   249 DYLWMLTGAESDPCSQLYAGPSPESDPEISQLTAYINNSIPEGTIKIYISLHSYGQYVLSPWGHT 313
            |..:...||..|||::.|.|||..|:.|::.:..:|   :..|..|.:::||:|.|.::.|:|:|
Zfish   261 DAEFSGPGASDDPCAEDYRGPSAHSEIEVTNIADFI---LSHGNFKSFMTLHAYSQLLMYPYGYT 322

  Fly   314 ALEFPEHYPQMMHVAKGFSDALYRRYGTVFTYGSSATTLYEVSGSGKEWAYAVKNIKIHYTIELR 378
            ....|:. |.:..||...:.||...:||::..||...|:.:.||:..:|||. ..||..:..|||
Zfish   323 GSNAPDQ-PDLHDVATQANKALNSWHGTIYKVGSIFHTIEQASGASVDWAYQ-HGIKYCFAFELR 385

  Fly   379 DKGELGFVLPPEDIIPVARE 398
            |.||.||:||.:.|:..|||
Zfish   386 DTGEYGFLLPADQIVSTARE 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14820	NP_648060.1	Propep_M14	31..100	CDD:280416	12/68 (18%)
CG14820	NP_648060.1	M14_CP_A-B_like	115..410	CDD:199844	107/293 (37%)
cpa2	NP_001003446.2	Propep_M14	27..97	CDD:280416	12/69 (17%)
cpa2	NP_001003446.2	Peptidase_M14_like	115..420	CDD:299699	107/298 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593484
Domainoid	1	1.000	251	1.000	Domainoid score	I2056
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	287	1.000	Inparanoid score	I2817
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	1	1.100	-	-	O	PTHR11705
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X86
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.800