DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14820 and CG4017

DIOPT Version :9

Sequence 1:	NP_648060.1	Gene:	CG14820 / 38754	FlyBaseID:	FBgn0035718	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_609309.1	Gene:	CG4017 / 34296	FlyBaseID:	FBgn0032143	Length:	424	Species:	Drosophila melanogaster

Alignment Length:	433	Identity:	167/433 - (38%)
Similarity:	254/433 - (58%)	Gaps:	36/433 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LLKILLVVG--LFGLARSVEQVRYDNYKVYN---VRIDDLEQFKLLH-TQERSLKLSSWREARHL 60
            ||.:||.|.  :|.||   |:.|:||||||.   |:.:.||..:.|. ..|.:|.|::    .||
  Fly     3 LLLLLLSVNILIFCLA---ERQRFDNYKVYRVSPVKANQLEGLRSLEANSEDALVLNN----LHL 60

  Fly    61 GESSDIMLPPEYQKTFESLLTKHNFTYNLKIDNVQTHI--------DAQRPKQRITSMEWTQFHT 117
            | .:|.::.|::..||..|:...:.:..|...|.||.:        ||.|   |.....|:::|.
  Fly    61 G-PTDFLVAPDFDGTFLKLVKDLDLSPELIDANAQTSLSLDIEPIADANR---RSDDYSWSEYHE 121

  Fly   118 LEEIYAWLDVIEDRYPDIVTPFTIGNSYEGRPIRGVKISYKEG---NPAVFIESNIHAREWITSA 179
            |.:.:.|:..:..:|||:|:.|..|.|||||.:.|::|::.:|   ..::|:|:.:||||||..|
  Fly   122 LNDTHRWMQNLVGKYPDVVSVFVAGQSYEGRELLGLRINHNDGRAEKQSIFLEAGMHAREWIGPA 186

  Fly   180 TITYFIDELLVPRNPAVRDIAQNVDWYIIPVLNTDGFAYSHEVERLWRKSRLPSDPTGECIGTDL 244
            |.|||.:|||..:...:.::|::..|||:|..|.||:.|:|:..|:|||:|.|.|.  .|:|||.
  Fly   187 TATYFANELLSSQQQEIMNLARSYVWYILPHANPDGYVYTHKTNRMWRKTRSPQDK--NCVGTDP 249

  Fly   245 NRNFDYLWMLTGAESDPCSQLYAGPSPESDPEISQLTAYINNSIPEGTIKIYISLHSYGQYVLSP 309
            |||:|:.|...||.|||||:.||||...|:||:..|:.:: .|:|| .:.:::||||:.|.:|.|
  Fly   250 NRNWDFHWREVGASSDPCSESYAGPKAFSEPEVQTLSQFL-KSVPE-PMFMFLSLHSFSQLLLYP 312

  Fly   310 WGHTALEFPEHYPQMMHVAKGFSDALYRRYGTVFTYGSSATTLYEVSGSGKEWAYAVKNIKIHYT 374
            :|||: ..||::.|:..:......|:.|||||.:|.|:....:|..:||..:|||.|.|:|..:|
  Fly   313 YGHTS-ALPENHRQLEQIFNTAVGAMKRRYGTRYTGGNVYDAIYPAAGSSMDWAYGVLNVKYSFT 376

  Fly   375 IELRDKGE---LGFVLPPEDIIPVAREVTEGFVGMIAAAREID 414
            .|||..|.   .||.||...|||..:|.|:..|.||.||.:|:
  Fly   377 YELRPSGYSFWTGFRLPAAQIIPTGQETTDSLVEMIKAAAQIE 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14820	NP_648060.1	Propep_M14	31..100	CDD:280416	19/77 (25%)
CG14820	NP_648060.1	M14_CP_A-B_like	115..410	CDD:199844	124/300 (41%)
CG4017	NP_609309.1	Propep_M14	30..97	CDD:280416	19/71 (27%)
CG4017	NP_609309.1	M14_CP_A-B_like	119..415	CDD:199844	124/300 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467031
Domainoid	1	1.000	224	1.000	Domainoid score	I1450
eggNOG	1	0.900	-	-		E1_COG2866
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	239	1.000	Inparanoid score	I2114
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		mtm6559
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	1	1.100	-	-	P	PTHR11705
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X86
	11	10.800