DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14820 and suro-1

DIOPT Version :9

Sequence 1:	NP_648060.1	Gene:	CG14820 / 38754	FlyBaseID:	FBgn0035718	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_492177.2	Gene:	suro-1 / 172557	WormBaseID:	WBGene00011235	Length:	664	Species:	Caenorhabditis elegans

Alignment Length:	467	Identity:	134/467 - (28%)
Similarity:	227/467 - (48%)	Gaps:	60/467 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLLKI--LLVVGLFGLARSVEQVRYDNYKVYNVRIDD---LEQFKLLHTQERSLKLSSWREARHL 60
            :||.:  :|:||....:..|.... |.|.:.:|...|   |...|.|...:....|..|:....:
Worm     8 ILLAVHTILLVGSVCCSTDVHNTD-DKYALIHVSAHDEQSLHLIKQLQLNDFKYDLDFWKSPSSI 71

  Fly    61 GESSDIMLP-PEYQKTFESLLTKHNFTYNLKIDNVQ------------TH--------------- 97
            .:.:|||:. .:.::....:|:..|.|.::.:.:|:            :|
Worm    72 SDKADIMVKRGKSERMLRQILSFANVTVSMSVPDVEKLIMRNEGTTSKSHLGFGSLSKWLHDDPI 136

  Fly    98 IDAQRPKQRITSM--------EWTQFHTLEEIYAWLDVIEDRYPDIVTPFTIGNSYEGRPIRGVK 154
            :|:: |...:|.:        .:..:.:..::..::..||..||.|.....||.::||:||.|:|
Worm   137 LDSE-PDLDLTKVGALKKAKYPFGDYASYADMVKYMRTIEFYYPRIAKIVRIGATHEGKPIEGLK 200

  Fly   155 ISYKEGNP--AVFIESNIHAREWITSATITYFIDELL--VPRNPAVRDIAQNVDWYIIPVLNTDG 215
            |..:..:.  ||:::.|||||||.:|.|..|||::|:  ..::..:.:....:|:||:|.||.||
Worm   201 IGARSSHKKRAVWVDGNIHAREWASSHTALYFINQLVSEYGKDAQITNYVDTLDFYIVPCLNPDG 265

  Fly   216 FAYSH----EVERLWRKSRLPS--DPT---GE--CIGTDLNRNFDYLWMLTGAESDPCSQLYAGP 269
            :.|:.    ...|||||:|.|.  .|:   ||  |.|.||||||.:.|...|:..:|||.:|.|.
Worm   266 YEYTRTSPIPTVRLWRKNRSPELCRPSLWGGEKCCRGVDLNRNFRFHWAERGSSYEPCSNIYHGE 330

  Fly   270 SPESDPEISQLTAYINNSIPEGTIKIYISLHSYGQYVLSPWGHTALEFPEHYPQMMHVAKGFSDA 334
            ...|:||...:..::.....:..:..:::||||.|..:.|:.|....:||...::...|:...:.
Worm   331 EVFSEPETRAVRNFLATPEMKDRVDAFVTLHSYAQLWIYPYSHEEQNYPEDIGELRKTARKAINR 395

  Fly   335 LYRRYGTVFTYGSSATTLYEVSGSGKEWAYAVKNIKIHYTIELRDKGEL--GFVLPPEDIIPVAR 397
            |.|.|||.:..|:.|.||...:|...:||.:..|:|..|.||||.:.||  ||:|..:::||.|.
Worm   396 LSRVYGTNYRMGTGADTLSPAAGGSDDWAKSALNVKYVYLIELRPQMELSNGFILHKKELIPTAV 460

  Fly   398 EVTEGFVGMIAA 409
            |..|||..::.|
Worm   461 ETFEGFREVVDA 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14820	NP_648060.1	Propep_M14	31..100	CDD:280416	15/99 (15%)
CG14820	NP_648060.1	M14_CP_A-B_like	115..410	CDD:199844	108/312 (35%)
suro-1	NP_492177.2	Propep_M14	39..110	CDD:280416	14/70 (20%)
		M14_CP_A-B_like	161..473	CDD:199844	108/312 (35%)
		ShK	620..657	CDD:279838
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	239	1.000	Inparanoid score	I2114
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		mtm4737
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X86
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.770