DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14820 and AGBL1

DIOPT Version :9

Sequence 1:	NP_648060.1	Gene:	CG14820 / 38754	FlyBaseID:	FBgn0035718	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001373023.1	Gene:	AGBL1 / 123624	HGNCID:	26504	Length:	1121	Species:	Homo sapiens

Alignment Length:	292	Identity:	64/292 - (21%)
Similarity:	92/292 - (31%)	Gaps:	121/292 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 FTYNLKIDNVQTHIDAQRPKQRITSMEWTQFHTLEEIYAWLDVIEDRYPDIVTPFTIGNSYEGRP 149
            :||..    :.||:|......           .|:|:|...||:..         |:|    |.|
Human   734 YTYTA----LMTHLDILEKSV-----------NLKEVYFRQDVLCQ---------TLG----GNP 770

  Fly   150 IRGVKI-SYKEGN-----------PAVFIESNIHARE----WITSATITYFIDELLVPRNPAVRD 198
            ...|.| :..|.|           |...|.:.:|..|    |:...|:     |.||..:|..|.
Human   771 CPLVTITAMPESNSDEHLEQFRHRPYQVITARVHPGESNASWVMKGTL-----EFLVSSDPVARL 830

  Fly   199 IAQNVDWYIIPVLNTDGFAYSHEVERLWRKSRLPSDPTGEC--IGTDLNRNFDYLWMLTGAESDP 261
            :.:|..:.|||:||.||....:.                .|  .|.||||.    |:
Human   831 LRENFIFKIIPMLNPDGVINGNH----------------RCSLSGEDLNRQ----WL-------- 867

  Fly   262 CSQLYAGPSPESDPEISQLTAYINNSIPEGTIKIYISLHSYG-QYVLSPWGHTALEFPEHYPQMM 325
                  .||....|.|                     .|:.| .|.||..|.:.:.|.:.:
Human   868 ------SPSAHLQPTI---------------------YHAKGLLYHLSSIGRSPVVFCDFH---- 901

  Fly   326 HVAKGFSDALYRRYGTVFTYGSS-ATTLYEVS 356
                |.|     :...||.||.| ..||::.:
Human   902 ----GHS-----QKKNVFLYGCSIKETLWQAA 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14820	NP_648060.1	Propep_M14	31..100	CDD:280416	4/14 (29%)
CG14820	NP_648060.1	M14_CP_A-B_like	115..410	CDD:199844	59/262 (23%)
AGBL1	NP_001373023.1	Pepdidase_M14_N	596..730	CDD:407865
AGBL1	NP_001373023.1	M14_Nna1	754..1019	CDD:349477	58/257 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900