Protein Alignment Prat2 and ADE4

DIOPT Version :9

• Sequence 1: NP_523949.2
• Gene: Prat2 / 38753
• FlyBaseID: FBgn0041194
• Length: 547
• Species: Drosophila melanogaster
• Sequence 2: NP_014029.1
• Gene: ADE4 / 855346
• SGDID: S000004915
• Length: 510
• Species: Saccharomyces cerevisiae
• Alignment Length: 507
• Identity: 161/507 - (31%)
• Similarity: 257/507 - (50%)
• Gaps: 53/507 - (10%)

  Fly    58 CGVFAAIACGDYPTQLDIAQMICLGLVALQHRGQESAGIVTSLGKSSKNFSVHKGMGMINNLFND 122
            ||:...:....   ...:|..:|.|.:.||||||::|||.| .|...:.:.. ||.||..::|..
Yeast     2 CGILGIVLANQ---TTPVAPELCDGCIFLQHRGQDAAGIAT-CGSRGRIYQC-KGNGMARDVFTQ 61

  Fly   123 EAIRKLKGNLGIGHTRYSTAAASEVVNCQPFVVHTAHGALAIAHNGELVNCESLRR---EVLERG 184
            :.:..|.|::||.|.||.||.:|.....|||.|::.:| :.:||||.|||..||:|   |.:.|.
Yeast    62 QRVSGLAGSMGIAHLRYPTAGSSANSEAQPFYVNSPYG-INLAHNGNLVNTASLKRYMDEDVHRH 125

  Fly   185 VGLSTHSDSELIAQSLCCAPEDVSEHDGPNWPARIRHFM----TLAPLSYSLV-VMHKDKIYAVR 244
            :  :|.|||||:........|..:::...|  ..:.|.:    .|....|:.| ::....::..|
Yeast   126 I--NTDSDSELLLNIFAAELEKHNKYRVNN--EDVFHALEGVYRLCRGGYACVGLLAGFALFGFR 186

  Fly   245 DSYGNRPLCLGKIVPVDAGHANINDQLAEGWVVSSESCGFLSIGARYVREVEPGEIIELSRN--- 306
            |..|.|||..|:         ..|....:.::::|||..|.:......|:::|||.:.:.:|
Yeast   187 DPNGIRPLLFGE---------RENPDGTKDYMLASESVVFKAHNFTKYRDLKPGEAVIIPKNCSK 242

  Fly   307 ---GYRTVDIVE--RPDYKRMAFCIFEYVYFARSDSMFEGQMVYSARLQCGRQLARE-----SPL 361
               .::.|..:.  |||       :||||||||.||:.:|..||..||..|.:||..     .|.
Yeast   243 GEPEFKQVVPINSYRPD-------LFEYVYFARPDSVLDGISVYHTRLAMGSKLAENILKQLKPE 300

  Fly   362 DADLVSSVPESGTAAAHGYARESGLPFGEVLCKNRYVGRTFIQPSTRLRQLGVAKKFGALAQNVE 426
            |.|:|..||::....|...|...|.|:.|...||||||||||.|:.|.|...|.:|...:....:
Yeast   301 DIDVVIPVPDTARTCALECANVLGKPYREGFVKNRYVGRTFIMPNQRERVSSVRRKLNPMESEFK 365

  Fly   427 GKRIVLVDDSIVRGNTIGPIIKLLRDAGATEVHIRIASPPLQYPCYMGINIPTREELIANKLNAD 491
            ||::::||||||||.|...|:.:.:::|||:|:...|:|.::|....||::...:.|||.....:
Yeast   366 GKKVLIVDDSIVRGTTSKEIVNMAKESGATKVYFASAAPAIRYNHIYGIDLTDTKNLIAYNRTDE 430

  Fly   492 QLADHVGADSLAYLSVEGLVKAVQMNKAHVNPLKAGYCTACLTGEYPGGLPE 543
            ::|:.:|.:.:.|.|:|.|:...:.:|  :...:.|    ..||.|..|:.:
Yeast   431 EVAEVIGCERVIYQSLEDLIDCCKTDK--ITKFEDG----VFTGNYVTGVED 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prat2	NP_523949.2	PurF	57..544	CDD:223112	161/507 (32%)
		GPATase_N	58..340	CDD:238367	91/297 (31%)
		PRTases_typeI	351..487	CDD:206754	53/140 (38%)
ADE4	NP_014029.1	PRK09246	1..502	CDD:236427	161/507 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	81	1.000	Domainoid score	I1998
eggNOG	1	0.900	-	-		E1_COG0034
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	224	1.000	Inparanoid score	I758
Isobase	1	0.950	-	0.591673	Normalized mean entropy	S1178
OMA	1	1.010	-	-		QHG60992
OrthoFinder	1	1.000	-	-		FOG0002622
OrthoInspector	1	1.000	-	-		otm46770
orthoMCL	1	0.900	-	-		OOG6_101156
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1034
SonicParanoid	1	1.000	-	-		X1724
TreeFam	1	0.960	-	-
	13	12.710