DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prat2 and ppat

DIOPT Version :9

Sequence 1:	NP_523949.2	Gene:	Prat2 / 38753	FlyBaseID:	FBgn0041194	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	NP_001076346.2	Gene:	ppat / 572027	ZFINID:	ZDB-GENE-041210-323	Length:	508	Species:	Danio rerio

Alignment Length:	510	Identity:	321/510 - (62%)
Similarity:	395/510 - (77%)	Gaps:	17/510 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 DATGMTCECGVFAAIACGDYPTQLDIAQMICLGLVALQHRGQESAGIVTSLGKSSKNFSVHKGMG 114
            :.:|:..|||||..:|.|::||||::||::.|||||||||||||||||||.|.:...||..||||
Zfish     4 EESGIGEECGVFGCVAAGEWPTQLEVAQILTLGLVALQHRGQESAGIVTSTGTNPPTFSTLKGMG 68

  Fly   115 MINNLFNDEAIRKLK-GNLGIGHTRYSTAAASEVVNCQPFVVHTAHGALAIAHNGELVNCESLRR 178
            ::|..|..|.:.||: ||||||||||||...||:.|||||||.|.||.:|:||||||||..:||:
Zfish    69 LVNTAFKPEDLLKLRYGNLGIGHTRYSTTGISELHNCQPFVVDTLHGKIAVAHNGELVNASALRK 133

  Fly   179 EVLERGVGLSTHSDSELIAQSLCCAPEDVSEHDGPNWPARIRHFMTLAPLSYSLVVMHKDKIYAV 243
            :|:..||||||.||||||.|.|...| .:.|.|.|:|.|||::.||..|.||||:||:||.||||
Zfish   134 KVMRHGVGLSTCSDSELITQLLALTP-PMEELDNPDWVARIKNLMTETPTSYSLLVMYKDVIYAV 197

  Fly   244 RDSYGNRPLCLGKIVPVDAGHAN-INDQLAEGWVVSSESCGFLSIGARYVREVEPGEIIELSRNG 307
            ||.|||||||:|::||:...|:: ..:...||||||||||.|.||||:|.|||:||||:::|:||
Zfish   198 RDPYGNRPLCIGRLVPISKLHSSGAGEADTEGWVVSSESCSFQSIGAKYYREVKPGEIVQISKNG 262

  Fly   308 YRTVDIVERPDYKRMAFCIFEYVYFARSDSMFEGQMVYSARLQCGRQLARESPLDADLVSSVPES 372
            ..::.:|.||:....||||||||||||.||||||||||:.|.:||||||.|:|.|||:||:||||
Zfish   263 VESLSVVPRPEGDLPAFCIFEYVYFARPDSMFEGQMVYTVRQRCGRQLAIEAPTDADVVSTVPES 327

  Fly   373 GTAAAHGYARESGLPFGEVLCKNRYVGRTFIQPSTRLRQLGVAKKFGALAQNVEGKRIVLVDDSI 437
            .|.||.|||::||||:.||||||||||||||||:|||||||||||||||..|:.|||:||:||||
Zfish   328 ATPAALGYAQQSGLPYVEVLCKNRYVGRTFIQPNTRLRQLGVAKKFGALTDNLAGKRVVLIDDSI 392

  Fly   438 VRGNTIGPIIKLLRDAGATEVHIRIASPPLQYPCYMGINIPTREELIANKLNADQLADHVGADSL 502
            ||||||.||||||::|||||||||:||||:::||||||||||:|||||||.....:|.::||.|:
Zfish   393 VRGNTISPIIKLLKEAGATEVHIRVASPPIRFPCYMGINIPTKEELIANKPEFKDIAGYIGATSV 457

  Fly   503 AYLSVEGLVKAVQMN-KAH---------VNPLKAGYCTACLTGEYPGGLPEELSW 547
            .|||||||:.|||.. ::|         ....:.|:|||||||:|    |.||.|
Zfish   458 RYLSVEGLLSAVQGGIESHGKDERISSTTKTTRIGHCTACLTGKY----PVELEW 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prat2	NP_523949.2	PurF	57..544	CDD:223112	317/498 (64%)
		GPATase_N	58..340	CDD:238367	173/283 (61%)
		PRTases_typeI	351..487	CDD:206754	108/135 (80%)
ppat	NP_001076346.2	PurF	10..506	CDD:223112	317/500 (63%)
		GPATase_N	12..295	CDD:238367	173/283 (61%)
		PRTases_typeI	306..442	CDD:206754	108/135 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596124
Domainoid	1	1.000	170	1.000	Domainoid score	I3735
eggNOG	1	0.900	-	-		E1_COG0034
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68272
Inparanoid	1	1.050	635	1.000	Inparanoid score	I806
OMA	1	1.010	-	-		QHG60992
OrthoDB	1	1.010	-	-		D257834at33208
OrthoFinder	1	1.000	-	-		FOG0002622
OrthoInspector	1	1.000	-	-		otm26540
orthoMCL	1	0.900	-	-		OOG6_101156
Panther	1	1.100	-	-	O	PTHR11907
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1034
SonicParanoid	1	1.000	-	-		X1724
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800