DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prat2 and ppat

DIOPT Version :9

Sequence 1:	NP_523949.2	Gene:	Prat2 / 38753	FlyBaseID:	FBgn0041194	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	NP_989313.1	Gene:	ppat / 394937	XenbaseID:	XB-GENE-972203	Length:	508	Species:	Xenopus tropicalis

Alignment Length:	507	Identity:	316/507 - (62%)
Similarity:	380/507 - (74%)	Gaps:	17/507 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 GMTCECGVFAAIACGDYPTQLDIAQMICLGLVALQHRGQESAGIVTSLGKSSKNFSVHKGMGMIN 117
            |:..|||||..||.|.:|||||:..:|.||||.||||||||||||||.|.|...:.:||||||:|
Frog     7 GIREECGVFGCIAAGSWPTQLDVPHVITLGLVGLQHRGQESAGIVTSDGSSVPTYKMHKGMGMVN 71

  Fly   118 NLFNDEAIRKL-KGNLGIGHTRYSTAAASEVVNCQPFVVHTAHGALAIAHNGELVNCESLRREVL 181
            ::|::|:::|| ..|||||||||||:..|.:.|||||||.|.||.:|:||||||||...|:|:|:
Frog    72 HVFSEESLKKLHMSNLGIGHTRYSTSGNSALENCQPFVVETLHGKIAVAHNGELVNAARLKRKVM 136

  Fly   182 ERGVGLSTHSDSELIAQSLCCAPEDVSEHDGPNWPARIRHFMTLAPLSYSLVVMHKDKIYAVRDS 246
            ..||||||.||||||.|.|...|....:|.. :|.||||:.|...|.||||:|||.|.|||:||.
Frog   137 RHGVGLSTSSDSELITQLLAFTPPQEEDHTA-DWIARIRNLMNETPTSYSLLVMHNDVIYAIRDP 200

  Fly   247 YGNRPLCLGKIVPVDAGHANINDQLAEGWVVSSESCGFLSIGARYVREVEPGEIIELSRNGYRTV 311
            |||||||:|:::||:...........||||||||||.||||||.|.||:.||||:::||.|.:|:
Frog   201 YGNRPLCIGRLMPVNNEGRGKRSAETEGWVVSSESCSFLSIGAEYYREILPGEIVKISREGVQTL 265

  Fly   312 DIVERPDYKRMAFCIFEYVYFARSDSMFEGQMVYSARLQCGRQLARESPLDADLVSSVPESGTAA 376
            |||.|.:....||||||||||||.||:||||||||.|.:||:|||.|:|::|||||:||||.|.|
Frog   266 DIVPRTNGDPSAFCIFEYVYFARPDSIFEGQMVYSVRRRCGQQLAIEAPVEADLVSTVPESATPA 330

  Fly   377 AHGYARESGLPFGEVLCKNRYVGRTFIQPSTRLRQLGVAKKFGALAQNVEGKRIVLVDDSIVRGN 441
            |.|||.:.||.:.||||||||||||||||:.||||||||||||.|:.|..|||:||:||||||||
Frog   331 ALGYAEKCGLQYVEVLCKNRYVGRTFIQPNMRLRQLGVAKKFGVLSDNFVGKRVVLIDDSIVRGN 395

  Fly   442 TIGPIIKLLRDAGATEVHIRIASPPLQYPCYMGINIPTREELIANKLNADQLADHVGADSLAYLS 506
            ||.||||||||:||.|||||:||||::|||||||||||:||||||:...:.||.::||||:.|||
Frog   396 TISPIIKLLRDSGAKEVHIRVASPPIKYPCYMGINIPTKEELIANRPEFNDLAGYIGADSVVYLS 460

  Fly   507 VEGLVKAVQMN----KAHVNPLKA-------GYCTACLTGEYPGGLPEELSW 547
            ||||..||:..    |...|.:..       |:|||||||||    |.||.|
Frog   461 VEGLTAAVREGVKAFKDEQNGINGKTKSSSHGHCTACLTGEY----PVELEW 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prat2	NP_523949.2	PurF	57..544	CDD:223112	312/498 (63%)
		GPATase_N	58..340	CDD:238367	169/282 (60%)
		PRTases_typeI	351..487	CDD:206754	104/135 (77%)
ppat	NP_989313.1	PurF	8..506	CDD:223112	312/502 (62%)
		GPATase_N	12..294	CDD:238367	169/282 (60%)
		PRTases_typeI	305..440	CDD:206754	103/134 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	161	1.000	Domainoid score	I3972
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H68272
Inparanoid	1	1.050	635	1.000	Inparanoid score	I824
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D257834at33208
OrthoFinder	1	1.000	-	-		FOG0002622
OrthoInspector	1	1.000	-	-		otm48392
Panther	1	1.100	-	-	O	PTHR11907
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1034
SonicParanoid	1	1.000	-	-		X1724
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190