DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prat2 and ade4

DIOPT Version :9

Sequence 1:	NP_523949.2	Gene:	Prat2 / 38753	FlyBaseID:	FBgn0041194	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	NP_001342845.1	Gene:	ade4 / 2543626	PomBaseID:	SPAC4D7.08c	Length:	533	Species:	Schizosaccharomyces pombe

Alignment Length:	524	Identity:	169/524 - (32%)
Similarity:	259/524 - (49%)	Gaps:	75/524 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 CGVFAAIACGDYPTQLDIAQMIC----LGLVALQHRGQESAGIVTSLGKSSKNFSVHKGMGMINN 118
            ||:.|.:..       |..|..|    .||.:||||||::|||||: |...:.:.. ||.||:.:
pombe     2 CGILALMLA-------DPHQQACPEIYEGLYSLQHRGQDAAGIVTA-GNKGRLYQC-KGSGMVAD 57

  Fly   119 LFNDEAIRKLKGNLGIGHTRYSTAAASEVVNCQPFVVHTAHGALAIAHNGELVNCESLRREV-LE 182
            :|:...:|:|.|::||||.||.||.:......|||.|::.:| |.:.|||.|:|...|||.: .|
pombe    58 VFSQHQLRQLVGSMGIGHLRYPTAGSCAHSEAQPFYVNSPYG-LVLGHNGNLINGPELRRFLDTE 121

  Fly   183 RGVGLSTHSDSELIAQSLC----------CAPEDVSEHDGPNWPARIRHFMTLAPLSYSLVVMHK 237
            ....::|.|||||:.....          ....|:.|        .:|:........|:.|.|..
pombe   122 AHRHVNTGSDSELLLNIFAYELQRLDKFRINENDIFE--------ALRNVYDRVNGGYACVAMIA 178

  Fly   238 D-KIYAVRDSYGNRPLCLGKIVPVDAGHANINDQLAEG--WVVSSESCGFLSIGARYVREVEPGE 299
            . .:...||..|.|||.:|:            ....||  ::::|||......|.|..|::.|||
pombe   179 GLGVLGFRDPNGIRPLVIGE------------RDTPEGKDYMLASESVVLTQFGYRTFRDIRPGE 231

  Fly   300 IIELSRN-------GYRTVDIVERPDYKRMAFC--IFEYVYFARSDSMFEGQMVYSARLQCGRQL 355
            .:.:.|:       |:|...:..|.....:.|.  |||||||||.||:.:|..||.:||..|.:|
pombe   232 CVFIRRSNREDILAGFRGPRLFSRQILPCLRFTPDIFEYVYFARPDSVIDGLSVYQSRLNMGEKL 296

  Fly   356 A-----RESP-----LDADLVSSVPESGTAAAHGYARESGLPFGEVLCKNRYVGRTFIQPSTRLR 410
            |     |..|     :||  |..||:|...:|...|:.:.||:.|...||||:|||||.|..::|
pombe   297 AHTIMKRFGPDYMEKIDA--VIPVPDSARTSALALAQTAQLPYVEAFIKNRYIGRTFIMPGQQIR 359

  Fly   411 QLGVAKKFGALAQNVEGKRIVLVDDSIVRGNTIGPIIKLLRDAGATEVHIRIASPPLQYPCYMGI 475
            :..|.:|.....|....|.:::||||||||.|...|:::.|::||..|::...:|.:.:|...||
pombe   360 RKSVRRKLNVQPQEFFDKNVLIVDDSIVRGTTSREIVQMARESGAKNVYLASCAPMITHPHVYGI 424

  Fly   476 NIPTREELIANKLNADQLADHVGADSLAYLSVEGLVKAVQMNKAHVNPLKAGYCTACLTGEYPGG 540
            ::...::|||.....|::|:.:.||.:.|.::|.|:.:.:  .|.:...:.|    ..||||..|
pombe   425 DLADCKDLIAYGKTEDEVAEAISADGVIYQTLEDLLDSCR--TAELTEFEVG----LFTGEYTTG 483

  Fly   541 LPEE 544
            ..:|
pombe   484 ASKE 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prat2	NP_523949.2	PurF	57..544	CDD:223112	168/522 (32%)
		GPATase_N	58..340	CDD:238367	97/308 (31%)
		PRTases_typeI	351..487	CDD:206754	52/145 (36%)
ade4	NP_001342845.1	GlmS	1..523	CDD:333118	169/524 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	81	1.000	Domainoid score	I2319
eggNOG	1	0.900	-	-		E1_COG0034
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	224	1.000	Inparanoid score	I893
OMA	1	1.010	-	-		QHG60992
OrthoFinder	1	1.000	-	-		FOG0002622
OrthoInspector	1	1.000	-	-		otm47216
orthoMCL	1	0.900	-	-		OOG6_101156
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1034
SonicParanoid	1	1.000	-	-		X1724
TreeFam	1	0.960	-	-
	12	11.760