DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prat2 and Ppat

DIOPT Version :9

Sequence 1:	NP_523949.2	Gene:	Prat2 / 38753	FlyBaseID:	FBgn0041194	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	NP_742158.1	Gene:	Ppat / 231327	MGIID:	2387203	Length:	517	Species:	Mus musculus

Alignment Length:	520	Identity:	320/520 - (61%)
Similarity:	395/520 - (75%)	Gaps:	34/520 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 GMTCECGVFAAIACGDYPTQLDIAQMICLGLVALQHRGQESAGIVTSLGKSSKNFSVHKGMGMIN 117
            |:..|||||..||.||:|||||:..:|.||||.||||||||||||||.|.:...|.||||||::|
Mouse     7 GIREECGVFGCIASGDWPTQLDVPHVITLGLVGLQHRGQESAGIVTSDGSAVPKFRVHKGMGLVN 71

  Fly   118 NLFNDEAIRKL-KGNLGIGHTRYSTAAASEVVNCQPFVVHTAHGALAIAHNGELVNCESLRREVL 181
            ::|.::.::|| ..|||||||||:|....|:.|||||||.|.||.:|:||||||||...||:::|
Mouse    72 HVFTEDNLKKLYDSNLGIGHTRYATTGKCELENCQPFVVETLHGKIAVAHNGELVNAARLRKKLL 136

  Fly   182 ERGVGLSTHSDSELIAQSLCCAPEDVSEHDGPNWPARIRHFMTLAPLSYSLVVMHKDKIYAVRDS 246
            .:|:||||.||||:|.|.|...|.. .:.|.|:|.|||::.|..||.:||||:||:|.||||||.
Mouse   137 RQGIGLSTSSDSEMITQLLAYTPPQ-EKDDAPDWVARIKNLMKEAPAAYSLVIMHRDFIYAVRDP 200

  Fly   247 YGNRPLCLGKIVPVDAGHANINDQ-----LAEGWVVSSESCGFLSIGARYVREVEPGEIIELSRN 306
            |||||||:|:::||    :::||:     ..||||||||||.||||||||..||:||||:|:||:
Mouse   201 YGNRPLCIGRLMPV----SDVNDKEKKSSETEGWVVSSESCSFLSIGARYCHEVKPGEIVEISRH 261

  Fly   307 GYRTVDIVERPDYKRMAFCIFEYVYFARSDSMFEGQMVYSARLQCGRQLARESPLDADLVSSVPE 371
            |.||:||:.|.:...:||||||||||||.|||||.||||:.|.:||:|||.|:|::|||||:|||
Mouse   262 GIRTLDIIPRSNGDPVAFCIFEYVYFARPDSMFEDQMVYTVRYRCGQQLAIEAPVEADLVSTVPE 326

  Fly   372 SGTAAAHGYARESGLPFGEVLCKNRYVGRTFIQPSTRLRQLGVAKKFGALAQNVEGKRIVLVDDS 436
            |.|.||.|||.:.|||:.||||||||||||||||:.||||||||||||.|:.|.:||||||:|||
Mouse   327 SATPAALGYATKCGLPYVEVLCKNRYVGRTFIQPNMRLRQLGVAKKFGVLSDNFKGKRIVLIDDS 391

  Fly   437 IVRGNTIGPIIKLLRDAGATEVHIRIASPPLQYPCYMGINIPTREELIANKLNADQLADHVGADS 501
            |||||||.||||||:::||.|||||:||||::|||:|||||||:|||||||...|.||:::||:|
Mouse   392 IVRGNTISPIIKLLKESGAKEVHIRVASPPIKYPCFMGINIPTKEELIANKPEFDCLAEYLGANS 456

  Fly   502 LAYLSVEGLVKAVQMN--------KAH-------VNPL----KAGYCTACLTGEYPGGLPEELSW 547
            :.||||||||.:||..        |.|       .|.|    |.|:|||||||:|    |.||.|
Mouse   457 VVYLSVEGLVSSVQQEIKFKKQKVKKHDIAIQENGNGLEYFEKTGHCTACLTGQY----PVELEW 517

Fly 548 547
Mouse 518 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prat2	NP_523949.2	PurF	57..544	CDD:223112	316/511 (62%)
		GPATase_N	58..340	CDD:238367	172/287 (60%)
		PRTases_typeI	351..487	CDD:206754	103/135 (76%)
Ppat	NP_742158.1	PurF	8..515	CDD:223112	316/515 (61%)
		GPATase_N	12..295	CDD:238367	172/287 (60%)
		PRTases_typeI	306..442	CDD:206754	103/135 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850233
Domainoid	1	1.000	162	1.000	Domainoid score	I3976
eggNOG	1	0.900	-	-		E1_COG0034
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68272
Inparanoid	1	1.050	629	1.000	Inparanoid score	I853
Isobase	1	0.950	-	0.591673	Normalized mean entropy	S1178
OMA	1	1.010	-	-		QHG60992
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002622
OrthoInspector	1	1.000	-	-		otm43249
orthoMCL	1	0.900	-	-		OOG6_101156
Panther	1	1.100	-	-	O	PTHR11907
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1034
SonicParanoid	1	1.000	-	-		X1724
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740