DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prat2 and ppat-1

DIOPT Version :9

Sequence 1:	NP_523949.2	Gene:	Prat2 / 38753	FlyBaseID:	FBgn0041194	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	NP_497958.1	Gene:	ppat-1 / 175613	WormBaseID:	WBGene00011407	Length:	480	Species:	Caenorhabditis elegans

Alignment Length:	493	Identity:	230/493 - (46%)
Similarity:	324/493 - (65%)	Gaps:	31/493 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 CGVFAAIACGDYPTQLDIAQMICLGLVALQHRGQESAGIVTSLGKSSKNFSVHKGMGMINNLFND 122
            ||:|..:|.|:| ..|::  :...||.||||||.||.|:|.|.|.:..:..:.||.|::.::..:
Worm     2 CGIFGIVAAGNY-EHLNV--LAANGLAALQHRGTESTGLVGSDGITRDHVEIIKGHGLVRDVITE 63

  Fly   123 EAIRKLKG-NLGIGHTRYSTAAASEV-VNC-QPFVVHTAHGALAIAHNGELVNCESLRREVLERG 184
            :.|.::.| ::.|||.|||||...:. :|| |||||:||.|.:|||||||||:.:..|:|||..|
Worm    64 DNISRMNGQSIIIGHNRYSTAGKKKSGINCVQPFVVYTAMGTVAIAHNGELVDAKQKRKEVLHEG 128

  Fly   185 VGLSTHSDSELIAQSL---------CCAPEDVSEHDGPNWPARIRHFMTLAPLSYSLVVMHKDKI 240
            |||||.:|||||||.:         |...:::.:     ....:...|:...:||||:||..|::
Worm   129 VGLSTDTDSELIAQMIAKAIALNVKCKYGQEMGD-----ITRELAVTMSALNMSYSLLVMTFDRL 188

  Fly   241 YAVRDSYGNRPLCLGKIVPVDAGHANINDQLAEGWVVSSESCGFLSIGARYVREVEPGEIIELSR 305
            ||:||.:||||||:|.:...:..        .|.::.|||||.| ...|:...||.||||:|||.
Worm   189 YAIRDPFGNRPLCVGTVYSKNGN--------PEAFIASSESCAF-PANAKLDFEVRPGEIVELST 244

  Fly   306 NGYRTVDIVERPDYKRMAFCIFEYVYFARSDSMFEGQMVYSARLQCGRQLARESPLDADLVSSVP 370
            .|.::|..: :|: ..:|.||||||||||:||..|||.|.:.|.:||:.:|.|..|:||:|.:||
Worm   245 GGIKSVWQM-KPN-TPLAMCIFEYVYFARNDSEIEGQQVQTVREECGKTMALEDDLEADIVGNVP 307

  Fly   371 ESGTAAAHGYARESGLPFGEVLCKNRYVGRTFIQPSTRLRQLGVAKKFGALAQNVEGKRIVLVDD 435
            :|..:||.|||.:||:.:..||.:|.||||:||:|:..:||..:..|||.|.:.:.|:|||||||
Worm   308 DSSLSAAIGYASQSGITYEPVLHRNSYVGRSFIEPNDEMRQNAIKMKFGVLKKKIHGQRIVLVDD 372

  Fly   436 SIVRGNTIGPIIKLLRDAGATEVHIRIASPPLQYPCYMGINIPTREELIANKLNADQLADHVGAD 500
            |||||||:..::|:||||||.|||:||||||:::||:|||||||.:||||.:....::...||||
Worm   373 SIVRGNTMRTLVKMLRDAGAKEVHLRIASPPVKFPCFMGINIPTTKELIAAEKTIPEICQFVGAD 437

  Fly   501 SLAYLSVEGLVKAVQMNKAHVNPLKAGYCTACLTGEYP 538
            |:.||||:|||.:||...........|:|||||||:||
Worm   438 SVRYLSVDGLVSSVQKGIERAANFSPGHCTACLTGKYP 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prat2	NP_523949.2	PurF	57..544	CDD:223112	230/493 (47%)
		GPATase_N	58..340	CDD:238367	123/293 (42%)
		PRTases_typeI	351..487	CDD:206754	78/135 (58%)
ppat-1	NP_497958.1	PurF	1..478	CDD:223112	230/493 (47%)
		GPATase_N	2..277	CDD:238367	123/293 (42%)
		PRTases_typeI	293..415	CDD:206754	69/121 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	113	1.000	Domainoid score	I3841
eggNOG	1	0.900	-	-		E1_COG0034
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68272
Inparanoid	1	1.050	420	1.000	Inparanoid score	I1006
Isobase	1	0.950	-	0.591673	Normalized mean entropy	S1178
OMA	1	1.010	-	-		QHG60992
OrthoDB	1	1.010	-	-		D257834at33208
OrthoFinder	1	1.000	-	-		FOG0002622
OrthoInspector	1	1.000	-	-		otm14542
orthoMCL	1	0.900	-	-		OOG6_101156
Panther	1	1.100	-	-	O	PTHR11907
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1034
SonicParanoid	1	1.000	-	-		X1724
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.820