DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vvl and Pou5f2

DIOPT Version :9

Sequence 1:	NP_001303384.1	Gene:	vvl / 38752	FlyBaseID:	FBgn0086680	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_001075220.2	Gene:	Pou5f2 / 680620	RGDID:	1589456	Length:	335	Species:	Rattus norvegicus

Alignment Length:	193	Identity:	80/193 - (41%)
Similarity:	116/193 - (60%)	Gaps:	20/193 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 EEDTPTSDDLEAFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLK 275
            |:.:....::|..||:.:|:|:.||::|||||.|:|.::|.|.||||||||||.|||..||.||:
  Rat   112 EDVSAIQKEMEQLAKELRQKRMTLGYSQADVGFAVGAMFGKVLSQTTICRFEAQQLSLANMWKLR 176

  Fly   276 PLLQKWLEEAD--STTGSPTSIDKIAAQGRKRKKRTSIEVSVKGALEQHFHKQPKPSAQEITSLA 338
            |||:.||||.|  :..|. ..::.|..|.||| :|.|.|..:...||:.|.:.|:|:.|:|:.:|
  Rat   177 PLLKMWLEEVDEKNLLGI-CRMEMILQQARKR-RRASRERRIGSNLEKLFLQCPEPTPQQISYIA 239

  Fly   339 DSLQLEKEVVRVWFCNRRQKEKRMTPPNT----LG--GDMMDGMP------PG-HM---HHGG 385
            ..|:|:|::|:|||.||.|.....|..::    :|  |....|.|      || |.   |:||
  Rat   240 GRLRLQKDLVQVWFSNRSQMAGWPTNDSSQRENVGATGAPFPGPPVCFPLAPGLHFDFPHYGG 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vvl	NP_001303384.1	POU	212..286	CDD:197673	40/73 (55%)
vvl	NP_001303384.1	Homeobox	307..360	CDD:278475	21/52 (40%)
Pou5f2	NP_001075220.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Pou	119..187	CDD:395105	40/67 (60%)
		homeodomain	<220..256	CDD:412151	15/35 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350544
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11636
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.940