DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vvl and pou3f1

DIOPT Version :9

Sequence 1:	NP_001303384.1	Gene:	vvl / 38752	FlyBaseID:	FBgn0086680	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_001016504.1	Gene:	pou3f1 / 549258	XenbaseID:	XB-GENE-853354	Length:	375	Species:	Xenopus tropicalis

Alignment Length:	450	Identity:	217/450 - (48%)
Similarity:	243/450 - (54%)	Gaps:	126/450 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAATSYMTP-----PSGDLDMALGGGGYHTSSPR--SAADAGEMKYMQHHHHHHAAAAAA----- 53
            ||||:...|     ||..|        .|..|.|  ......|::.|.|..:....|..|
Frog     1 MAATAQYLPRNNSLPSNPL--------MHPDSDRMHQGTTYREVQKMMHQEYLQGLATNAGHPMS 57

  Fly    54 -AHHQLPSSPSPNGQGNGGGLGLGSGSGLGSWSALHPDPWMQT----------HHTHHLPAAAAV 107
             .|||...:|:.:         .||||.||: .|.|....:|:          ||..||
Frog    58 LTHHQWLPNPASD---------WGSGSHLGA-QAEHGKSGVQSSREDLSSSFHHHRSHL------ 106

  Fly   108 ASAADTVKQEMSHLSQQTRIQQGMASPHAAWHAPHAGHYAP--TGGS----PLQYHHA----MNG 162
                         :.|||      .|.| || |...||:.|  :.||    ||.|..:    :||
Frog   107 -------------VHQQT------PSSH-AW-AQSGGHHLPPMSPGSNSHQPLIYSQSSYTNLNG 150

  Fly   163 MLHHPAHAVAAAHHQSVAPLH--------HTLRGESPQLHIHHHMGGGDRDAISGGEEDTPTSDD 219
            ||...|   ::.||....|||        |.   |||..|:.||....|        ||.|:|||
Frog   151 MLGPQA---SSLHHSMRDPLHDDPGVLDTHV---ESPPQHLSHHQDHSD--------EDAPSSDD 201

  Fly   220 LEAFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLQKWLEE 284
            ||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||
Frog   202 LEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEE 266

  Fly   285 ADSTTGSPTSIDKIAAQGRKRKKRTSIEVSVKGALEQHFHKQPKPSAQEITSLADSLQLEKEVVR 349
            .||||||||::||||||||||||||||||.||||||.||.|.|||||.|||||||||||||||||
Frog   267 TDSTTGSPTNLDKIAAQGRKRKKRTSIEVGVKGALENHFLKCPKPSAHEITSLADSLQLEKEVVR 331

  Fly   350 VWFCNRRQKEKRMTPPNTLGGDMMDGMPPGHMHHGGYHPHHDMHGSPM-GTHSHSHSPPM 408
            |||||||||||||||.         |:|         ||       || ..:|.:.:||:
Frog   332 VWFCNRRQKEKRMTPA---------GVP---------HP-------PMEDVYSQAETPPL 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vvl	NP_001303384.1	POU	212..286	CDD:197673	69/73 (95%)
vvl	NP_001303384.1	Homeobox	307..360	CDD:278475	47/52 (90%)
pou3f1	NP_001016504.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29		11/35 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	56..139		31/119 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..200		19/62 (31%)
		POU	194..268	CDD:197673	69/73 (95%)
		Homeobox	289..343	CDD:365835	48/53 (91%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	139	1.000	Domainoid score	I4743
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	308	1.000	Inparanoid score	I2579
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D328823at33208
OrthoFinder	1	1.000	-	-		FOG0000890
OrthoInspector	1	1.000	-	-		otm48484
Panther	1	1.100	-	-	O	PTHR11636
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3844
SonicParanoid	1	1.000	-	-		X514
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.100