Protein Alignment vvl and pou2f1

DIOPT Version :10

• Sequence 1: NP_001303384.1
• Gene: vvl / 38752
• FlyBaseID: FBgn0086680
• Length: 742
• Species: Drosophila melanogaster
• Sequence 2: XP_012812406.1
• Gene: pou2f1 / 549091
• XenbaseID: XB-GENE-853992
• Length: 764
• Species: Xenopus tropicalis
• Alignment Length: 683
• Identity: 192/683 - (28%)
• Similarity: 276/683 - (40%)
• Gaps: 215/683 - (31%)

  Fly    51 AAAAHHQLPSSPSPNGQGNGGGLGLGSGSGLGSWSALHPDPWMQTHHTHHLPAAAAVASAADTVK 115
            |||..|      |.:.|.:..|..:         ||....|..|      :|.:..:..|.|.
 Frog   154 AAAVQH------SASQQHSAAGATI---------SASAATPMTQ------IPLSQPIQIAQDL-- 195

  Fly   116 QEMSHLSQQTRIQQGMASPHAAWHAPHAG---HYAPTGGSPL---------------------QY 156
            |::..|.||....|.....|...:.|.|.   ...|.|...|                     |.
 Frog   196 QQLQQLQQQNLNLQQFVLVHPTTNLPPAQFIISQTPQGQQGLLQAQNLLTQLPQQSQANLLQSQP 260

  Fly   157 HHAMNGMLHHPAHAVAAAHHQSVAPLHHTL--RGESPQLHIHHHMGGGDRDAISGGEEDTPTSDD 219
            ...:......|...:||...|.: |...|.  |.::|.|                  |:....::
 Frog   261 SITLTSQPATPTRTIAATPVQQL-PQSQTTPKRIDTPSL------------------EEPSDLEE 306

  Fly   220 LEAFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLQKWLEE 284
            ||.|||.||||||||||||.|||||:|.||||.||||||.|||||.|||||||||||||:|||.:
 Frog   307 LEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLND 371

  Fly   285 A-------DSTTGSPTSIDK----IAAQGRKRKKRTSIEVSVKGALEQHFHKQPKPSAQEITSLA 338
            |       ||:..:.:.::.    :....|:||||||||.:::.|||:.|.:..||:::|||.:|
 Frog   372 AVLENITSDSSLSNQSVLNSPGHGMEGLNRRRKKRTSIETNIRVALEKSFLENQKPTSEEITMIA 436

  Fly   339 DSLQLEKEVVRVWFCNRRQKEKRMTPPNTLGGDMMDGMPPGHMHHGGYHPHHDMHGSPMGTHSHS 403
            |.|.:||||:|||||||||||||:.||::.|..                      .||:.:...|
 Frog   437 DQLNMEKEVIRVWFCNRRQKEKRINPPSSGGSS----------------------SSPIKSLFSS 479

  Fly   404 HSPPMLSPQNMQSSAVAAHQLAAHXQSEIQESNSAAAASTPASLNSLSQQQQQQQQQQQQQHQQQ 468
            .:|.:.:..::.:|:.|.   ... ...:..:::||..|.|
 Frog   480 ANPLVATTPSLVTSSTAT---TLTVNPVLPLTSAAAITSFP------------------------ 517

  Fly   469 QQHQQQQHTPNTPSSSAGSSAT-----------MTSQVMSPQSPLGSSSAGNQANNNNNNNNNNN 522
                    .|.|..:|:.::||           :||..:|| || .:::|.::|:..:..:..:.
 Frog   518 --------VPGTTGTSSANTATVISTAPPVSSVLTSPSLSP-SP-SATAATSEASTASGTSTTHT 572

  Fly   523 SSTNNNNNNNNNEEQVKHH---------QQQQQQQQASSIAAAAAAAMYMDPMRYQHPHHPHPHP 578
            :||...:..:..:..|...         |...|...::|:||.||||
 Frog   573 TSTPLTSPLSTGQVMVTASGIHTAATALQGAAQLPTSASLAAMAAAA------------------ 619

  Fly   579 HQHPHLNPAHHPHLFHTSDQLQHSQQQTVGGT-------SSNSQLSPGAGSNSGL-PLQPPSSA- 634
                .|||.           |....|...||.       :..|.|||...|||.| .:|..:|:
 Frog   620 ----GLNPG-----------LMAPSQFAAGGALFSLNPGALGSALSPALMSNSTLATIQALASSG 669

  Fly   635 ---------------SPAGSASSVLGGHLNLNP 652
                           :.||...:::...|.|||
 Frog   670 SLPITSLDATGNLVFANAGGTPNIVTAPLFLNP 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vvl	NP_001303384.1	POU	212..286	CDD:197673	56/80 (70%)
		Homeodomain	305..361	CDD:459649	35/55 (64%)
pou2f1	XP_012812406.1	POU	299..372	CDD:197673	55/72 (76%)
		Homeodomain	403..459	CDD:459649	35/55 (64%)
		POU2F1_C	473..750	CDD:437368	56/300 (19%)