DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vvl and POU5F1

DIOPT Version :9

Sequence 1:	NP_001303384.1	Gene:	vvl / 38752	FlyBaseID:	FBgn0086680	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_002692.2	Gene:	POU5F1 / 5460	HGNCID:	9221	Length:	360	Species:	Homo sapiens

Alignment Length:	393	Identity:	138/393 - (35%)
Similarity:	176/393 - (44%)	Gaps:	113/393 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 SPSPNGQGNG---------------------GGLGLGSGSGLGS--WSALH-PDPWMQTHHTHHL 101
            ||.|.|.|:|                     ||.|:|.|.|.||  |.... |.|:
Human    12 SPPPGGGGDGPGGPEPGWVDPRTWLSFQGPPGGPGIGPGVGPGSEVWGIPPCPPPY--------- 67

  Fly   102 PAAAAVASAADTVKQEMSHLSQQTRIQQGMASPHAAWHAPHAG-HYAPTGGSPLQYHHAMNGMLH 165
                                    ....||     |:..|..| ...|.||..........|:
Human    68 ------------------------EFCGGM-----AYCGPQVGVGLVPQGGLETSQPEGEAGV-- 101

  Fly   166 HPAHAVAAAHHQSVAPLHHTLRGESPQLHIHHHMGGGDRDAISGGEEDT----PTSDDLEAFAKQ 226
                 ...::....:|...|:...:.:|         :::.:....|::    ....:||.|||.
Human   102 -----GVESNSDGASPEPCTVTPGAVKL---------EKEKLEQNPEESQDIKALQKELEQFAKL 152

  Fly   227 FKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEADSTTGS 291
            .||:||.||:|||||||.||.|:|.|||||||||||||||||||||||:||||||:||||:.
Human   153 LKQKRITLGYTQADVGLTLGVLFGKVFSQTTICRFEALQLSFKNMCKLRPLLQKWVEEADNN--- 214

  Fly   292 PTSIDKIA-----AQGRKRKKRTSIEVSVKGALEQHFHKQPKPSAQEITSLADSLQLEKEVVRVW 351
             .::.:|.     .|.||| ||||||..|:|.||..|.:.|||:.|:|:.:|..|.|||:|||||
Human   215 -ENLQEICKAETLVQARKR-KRTSIENRVRGNLENLFLQCPKPTLQQISHIAQQLGLEKDVVRVW 277

  Fly   352 FCNRRQKEKRMTPPNT------------LGGDMMDGMPPG-HMHHGGYHPHHDMHGSPMGTHSHS 403
            |||||||.||.:....            .||.:...:.|| |....||       |||..|..:|
Human   278 FCNRRQKGKRSSSDYAQREDFEAAGSPFSGGPVSFPLAPGPHFGTPGY-------GSPHFTALYS 335

  Fly   404 HSP 406
            ..|
Human   336 SVP 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vvl	NP_001303384.1	POU	212..286	CDD:197673	54/77 (70%)
vvl	NP_001303384.1	Homeobox	307..360	CDD:278475	33/52 (63%)
POU5F1	NP_002692.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		11/39 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	88..114		4/32 (13%)
		POU	138..212	CDD:197673	53/73 (73%)
		DNA binding. /evidence=ECO:0000250\|UniProtKB:P20263	180..186		5/5 (100%)
		DNA binding. /evidence=ECO:0000250\|UniProtKB:P20263	193..196		2/2 (100%)
		Homeobox	233..287	CDD:365835	33/53 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156629
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840