Protein Alignment vvl and POU4F3

DIOPT Version :10

• Sequence 1: NP_001303384.1
• Gene: vvl / 38752
• FlyBaseID: FBgn0086680
• Length: 742
• Species: Drosophila melanogaster
• Sequence 2: NP_002691.1
• Gene: POU4F3 / 5459
• HGNCID: 9220
• Length: 338
• Species: Homo sapiens
• Alignment Length: 328
• Identity: 128/328 - (39%)
• Similarity: 171/328 - (52%)
• Gaps: 59/328 - (17%)

  Fly    62 PSPNGQGNGGGLGLGSGSGLGSWSAL-----------HPDPWMQTHHTHHLPAAAAVASAADTVK 115
            |:|..|||  ..|....|.|....||           ||   .:...|:|..::....|.:.||
Human    37 PAPQLQGN--IFGSFDESLLARAEALAAVDIVSHGKNHP---FKPDATYHTMSSVPCTSTSSTV- 95

  Fly   116 QEMSHLSQQTRIQQGMASPHAAWHAPHAG-------HYAPT---GGSPLQYHHAMNGMLHHPAHA 170
             .:||.:..|      :.||   ||.|.|       |.:||   .|.....|..|...: ||.|.
Human    96 -PISHPAALT------SHPH---HAVHQGLEGDLLEHISPTLSVSGLGAPEHSVMPAQI-HPHHL 149

  Fly   171 VAAAH-HQSVAPLH-HTLRGESPQLHIHHHMGGGDRDAISGGEEDTPTSDDLEAFAKQFKQRRIK 233
            .|..| ||::...| ||:   :|    |..|..    .:|..|.|   ..:|||||::|||||||
Human   150 GAMGHLHQAMGMSHPHTV---AP----HSAMPA----CLSDVESD---PRELEAFAERFKQRRIK 200

  Fly   234 LGFTQADVGLALGTL----YGNVFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEADSTTGSPTS 294
            ||.||||||.||..|    .|:: ||:||||||:|.||..||..|||:||.|||||::......|
Human   201 LGVTQADVGAALANLKIPGVGSL-SQSTICRFESLTLSHNNMIALKPVLQAWLEEAEAAYREKNS 264

  Fly   295 IDKIAAQGRKRKKRTSIEVSVKGALEQHFHKQPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKE 359
            ..::.....:::|||||....|.:||.:|..||:||:::|.::|:.|.|:|.||||||||:|||:
Human   265 KPELFNGSERKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQ 329

  Fly   360 KRM 362
            |||
Human   330 KRM 332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vvl	NP_001303384.1	POU	212..286	CDD:197673	47/77 (61%)
		Homeodomain	305..361	CDD:459649	29/55 (53%)
POU4F3	NP_002691.1	POU-IV box	56..65		2/8 (25%)
		POU	179..256	CDD:197673	48/80 (60%)
		Homeodomain	275..331	CDD:459649	29/55 (53%)