DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vvl and POU4F2

DIOPT Version :9

Sequence 1:	NP_001303384.1	Gene:	vvl / 38752	FlyBaseID:	FBgn0086680	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_004566.2	Gene:	POU4F2 / 5458	HGNCID:	9219	Length:	409	Species:	Homo sapiens

Alignment Length:	442	Identity:	145/442 - (32%)
Similarity:	193/442 - (43%)	Gaps:	133/442 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SYMTPPSGDLDMALGGGGYHTSSPRSAADAGEMKYMQHHHHHHAAAAAAAHHQLPSSPSPNGQGN 69
            ::..|..|.|.:.......|::||.|:|.              .|.:|::    |||.|..|.|.
Human    11 AFSMPHGGSLHVEPKYSALHSTSPGSSAP--------------IAPSASS----PSSSSNAGGGG 57

  Fly    70 GGGLGLGSGSGLGSWS----------------ALHPDP--------------------------W 92
            |||.|.|.|.|..|.|                |..|.|                          .
Human    58 GGGGGGGGGGGRSSSSSSSGSSGGGGSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDIVSQ 122

  Fly    93 MQTHH-------------THHLPAAAAVASAADTVKQEMSHLSQQTRIQQGMASPHAAWHAPHAG 144
            .::||             |:|........|||.:....:||.|       .:|..|...|..|..
Human   123 SKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISHPS-------ALAGTHHHHHHHHHH 180

  Fly   145 HYAPTGGSPLQYHHAMNG-MLHH--------------------PAHAVAAAHHQSVAPLHHTLRG 188
            |:.|        |.|:.| :|.|                    |||   |.|..::.|:|   :.
Human   181 HHQP--------HQALEGELLEHLSPGLALGAMAGPDGAVVSTPAH---APHMATMNPMH---QA 231

  Fly   189 ESPQLHIH---HHMG-GGDRDAISGGEEDTPTSDDLEAFAKQFKQRRIKLGFTQADVGLALGTL- 248
            .....|.|   .||| ..|.||         ...||||||::|||||||||.||||||.||..|
Human   232 ALSMAHAHGLPSHMGCMSDVDA---------DPRDLEAFAERFKQRRIKLGVTQADVGSALANLK 287

  Fly   249 ---YGNVFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEADSTTGSPTSIDKIAAQGRKRKKRTS 310
               .|:: ||:||||||:|.||..||..|||:||.|||||:.:.....:..::.....|::||||
Human   288 IPGVGSL-SQSTICRFESLTLSHNNMIALKPILQAWLEEAEKSHREKLTKPELFNGAEKKRKRTS 351

  Fly   311 IEVSVKGALEQHFHKQPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRM 362
            |....|.:||.:|..||:||:::|.::|:.|.|:|.||||||||:|||:|||
Human   352 IAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRM 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vvl	NP_001303384.1	POU	212..286	CDD:197673	47/77 (61%)
vvl	NP_001303384.1	Homeobox	307..360	CDD:278475	29/52 (56%)
POU4F2	NP_004566.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..93		23/84 (27%)
		Required for transcriptional activation. /evidence=ECO:0000250\|UniProtKB:Q63934	91..237		30/166 (18%)
		POU-IV box	110..119		0/8 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..188		12/49 (24%)
		Nuclear speckle targeting signal. /evidence=ECO:0000269\|PubMed:19266028	171..185		5/21 (24%)
		Required for DNA-binding and transcriptional repression. /evidence=ECO:0000250\|UniProtKB:Q63934	238..409		88/176 (50%)
		POU	250..327	CDD:197673	50/86 (58%)
		Homeobox	348..401	CDD:278475	29/52 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156606
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740