Protein Alignment vvl and POU3F2

DIOPT Version :10

• Sequence 1: NP_001303384.1
• Gene: vvl / 38752
• FlyBaseID: FBgn0086680
• Length: 742
• Species: Drosophila melanogaster
• Sequence 2: NP_005595.2
• Gene: POU3F2 / 5454
• HGNCID: 9215
• Length: 443
• Species: Homo sapiens
• Alignment Length: 460
• Identity: 225/460 - (48%)
• Similarity: 244/460 - (53%)
• Gaps: 107/460 - (23%)

  Fly     2 AATSYMTPPSGDLDMALGGGGYHTSSPRSAADAGEMKYMQHH-HHHHAAAAAAAHHQLPSSPSPN 65
            |:..:..||.|   |..|.|||..:......|.|.::...|. .|.|....|.:|    ......
Human    16 ASIVHAEPPGG---MQQGAGGYREAQSLVQGDYGALQSNGHPLSHAHQWITALSH----GGGGGG 73

  Fly    66 GQGNGGGLGLGSGSGLGS-WSA----------------------LH-PDPWMQTHHTHHLPAAAA 106
            |.|.|||.|.|.|.|.|| ||.                      || |....|.|....
Human    74 GGGGGGGGGGGGGGGDGSPWSTSPLGQPDIKPSVVVQQGGRGDELHGPGALQQQHQQQQ------ 132

  Fly   107 VASAADTVKQEMSHLSQQTRIQQGMASPHAAWHAPH-------------AGHYAPTGGSP---LQ 155
                    :|:.....||.:.||....||...||.:             |.|..|:.|:.   |.
Human   133 --------QQQQQQQQQQQQQQQQQRPPHLVHHAANHHPGPGAWRSAAAAAHLPPSMGASNGGLL 189

  Fly   156 YHH---AMNGM---------LHHPAHAVAAAHHQSVAPLHHTLRGESPQLHIHHHM--------- 199
            |..   .:|||         |||  |.:..||.:.....||      |..|.|.|.
Human   190 YSQPSFTVNGMLGAGGQPAGLHH--HGLRDAHDEPHHADHH------PHPHSHPHQQPPPPPPPQ 246

  Fly   200 -----GGGDRDAISGGEEDTPTSDDLEAFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTIC 259
                 .|...|..|  :||||||||||.|||||||||||||||||||||||||||||||||||||
Human   247 GPPGHPGAHHDPHS--DEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTIC 309

  Fly   260 RFEALQLSFKNMCKLKPLLQKWLEEADSTTGSPTSIDKIAAQGRKRKKRTSIEVSVKGALEQHFH 324
            |||||||||||||||||||.||||||||::|||||||||||||||||||||||||||||||.||.
Human   310 RFEALQLSFKNMCKLKPLLNKWLEEADSSSGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFL 374

  Fly   325 KQPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPP-NTLGG--DMMDG---MPPGHMHH 383
            |.||||||||||||||||||||||||||||||||||||||| .||.|  |:..|   .||   ||
Human   375 KCPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGGTLPGAEDVYGGSRDTPP---HH 436

  Fly   384 GGYHP 388
            |...|
Human   437 GVQTP 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vvl	NP_001303384.1	POU	212..286	CDD:197673	71/73 (97%)
		Homeodomain	305..361	CDD:459649	52/55 (95%)
POU3F2	NP_005595.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	64..171		29/124 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..267		19/75 (25%)
		POU	262..336	CDD:197673	71/73 (97%)
		Homeodomain	355..411	CDD:459649	52/55 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	409..443		18/36 (50%)