DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vvl and CCHCR1

DIOPT Version :9

Sequence 1:	NP_001303384.1	Gene:	vvl / 38752	FlyBaseID:	FBgn0086680	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_001381570.1	Gene:	CCHCR1 / 54535	HGNCID:	13930	Length:	880	Species:	Homo sapiens

Alignment Length:	543	Identity:	98/543 - (18%)
Similarity:	182/543 - (33%)	Gaps:	161/543 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 LPAAAAVASAADTVKQEMSHLS---------QQTRIQQGM------------ASPHAAWHAPHAG 144
            |..:.|::..|:.:.:::..|.         ::|.:||.|            |....|..|...|
Human   179 LEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEG 243

  Fly   145 HYAPTGGSPLQYHHAMNG---------MLH-HPAHAVAAAHHQSVAPLHHTLRGESPQLHIHHHM 199
            ..|...|:.:...:...|         .|| ....::..||.::::.|.....|....|......
Human   244 LRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETR 308

  Fly   200 GGGDRDAISGGEED--------TPTSDDLEA--------------------FAKQFKQRRIKLGF 236
            ..|:...::..:.:        :.|.:||||                    .::.::..|.||..
Human   309 RAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLE 373

  Fly   237 TQADVGLALGTLYG-------NVFSQTTICRF------------EALQLSFKNMCKLKPLLQKW- 281
            |...:.....:|:.       .|.|.|.|...            ::|:..|...|  :.||.:|
Human   374 TMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKC--QSLLNRWR 436

  Fly   282 --------------LEEADST---TGSPTSI-DKIAAQGRK--------RKKRTSIEVSVKGA-- 318
                          ||.:||.   .|...|: :|:.:|.::        :.|...:||...||
Human   437 EKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKG 501

  Fly   319 --LEQHFHKQPKPSAQEITSLA-DSLQLEKEVV---RVWFCNRRQKEKRMTPPNTLGGDMMDGMP 377
              ||....::.:...|:.|:.| :.|:|....|   ::|.      |..|.........:
Human   502 LQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWL------ETTMAKVEGAAAQL----- 555

  Fly   378 PGHMHHGGY--HPHHDMHG--------SPMGTHSHSHSPPM----LSPQNM---QSSAVAAHQLA 425
            |...:...|  ...|.:.|        :.:...|....||:    |..|.:   ::...|..||:
Human   556 PSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLS 620

  Fly   426 AH-XQSEIQESNSAAAASTPASLNSLSQQQQQQQQQQQQ-------QHQQQQQHQQQQHTPNTPS 482
            |.  |.|:..:.....|.. ..|:.::||.:|:.||.|:       |.:..:|.||:
Human   621 ARLIQQEVGRAREQGEAER-QQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQE-------- 676

  Fly   483 SSAGSSATMTSQVMSPQSPLGSS 505
             |...:|::..::...|...|.:
Human   677 -STEEAASLRQELTQQQELYGQA 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vvl	NP_001303384.1	POU	212..286	CDD:197673	22/135 (16%)
vvl	NP_001303384.1	Homeobox	307..360	CDD:278475	14/60 (23%)
CCHCR1	NP_001381570.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900