DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vvl and pou3f2b

DIOPT Version :9

Sequence 1:	NP_001303384.1	Gene:	vvl / 38752	FlyBaseID:	FBgn0086680	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_571235.1	Gene:	pou3f2b / 30397	ZFINID:	ZDB-GENE-980526-370	Length:	378	Species:	Danio rerio

Alignment Length:	402	Identity:	205/402 - (50%)
Similarity:	234/402 - (58%)	Gaps:	76/402 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 TSSPRSA-ADAGEMKYMQHHHHHHAAAAAAAHHQLPSSPSPNGQGNGGGLGLGSGSGLGSWSA-- 86
            ||||... ::.|.|:  |...:..|.....:.:.|.|:..|....:.....|..|.| |.||:
Zfish    13 TSSPSIVHSEPGSMQ--QATAYRDAQTLLQSDYSLQSNSHPLSHAHQWITALSHGEG-GPWSSSP 74

  Fly    87 -----LHPDPWMQTHHTHHLPAAAAVASAADTVKQEMSHLSQQTR----IQQGMASPH--AAWHA 140
                 :.|                ||.|..|.: ...|:|..|:|    :.|...:.|  .||..
Zfish    75 LGEQDIKP----------------AVQSPRDEM-HNSSNLQHQSRPPHLVHQTHGNHHDSRAWRT 122

  Fly   141 PHAGH---YAPTGGSPLQYHH---AMNGM-------LHHPAHAVAAAHHQSVAPLHHTLRGESPQ 192
            ..|.|   .|.:.|..|.|..   ::||:       :||  |::..||....:| |.:..|..|.
Zfish   123 TTAAHIPSMATSNGQSLIYSQPSFSVNGLIPGSGQGIHH--HSMRDAHEDHHSP-HLSDHGHPPS 184

  Fly   193 LHIH-----HHMGGGDRDAISGGEEDTPTSDDLEAFAKQFKQRRIKLGFTQADVGLALGTLYGNV 252
            .|.|     ||         ...:||||||||||.||||||||||||||||||||||||||||||
Zfish   185 QHQHQSHQSHH---------DHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNV 240

  Fly   253 FSQTTICRFEALQLSFKNMCKLKPLLQKWLEEADSTTGSPTSIDKIAAQGRKRKKRTSIEVSVKG 317
            ||||||||||||||||||||||||||.|||||||||:|||||:||||||||||||||||||||||
Zfish   241 FSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSTSGSPTSLDKIAAQGRKRKKRTSIEVSVKG 305

  Fly   318 ALEQHFHKQPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPNTLGG------DMMDGM 376
            |||.||.|.|||:|.|||||||||||||||||||||||||||||||||   ||      |:....
Zfish   306 ALESHFLKCPKPAASEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPP---GGPLPGTEDVYGDT 367

  Fly   377 PPGHMHHGGYHP 388
            ||   |||...|
Zfish   368 PP---HHGVQTP 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vvl	NP_001303384.1	POU	212..286	CDD:197673	71/73 (97%)
vvl	NP_001303384.1	Homeobox	307..360	CDD:278475	47/52 (90%)
pou3f2b	NP_571235.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		6/16 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	86..118		8/32 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..205		17/65 (26%)
		POU	200..274	CDD:197673	71/73 (97%)
		Homeobox	295..348	CDD:278475	47/52 (90%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..378		16/36 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	139	1.000	Domainoid score	I4736
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	324	1.000	Inparanoid score	I2470
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D328823at33208
OrthoFinder	1	1.000	-	-		FOG0000890
OrthoInspector	1	1.000	-	-		otm24456
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11636
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3844
SonicParanoid	1	1.000	-	-		X514
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.960