DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vvl and pou3f3a

DIOPT Version :9

Sequence 1:	NP_001303384.1	Gene:	vvl / 38752	FlyBaseID:	FBgn0086680	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_571225.2	Gene:	pou3f3a / 30386	ZFINID:	ZDB-GENE-980526-220	Length:	446	Species:	Danio rerio

Alignment Length:	453	Identity:	225/453 - (49%)
Similarity:	254/453 - (56%)	Gaps:	102/453 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 MALGGGGY-----H---TSSPRSAADAGEMKYMQHHHHHHAAAAAAAHHQLPSSPSPNGQ-GNGG 71
            ||...||:     |   ||.|.:||.|..           |||||||....|.|.||.|. |:..
Zfish    63 MAASNGGHMLSHAHQWVTSLPHAAAAAAA-----------AAAAAAAEAGSPWSSSPVGMAGSPQ 116

  Fly    72 GLGLGSGSG---LGSWSALHPDP-WMQTHHTHHLPAAAAVASAADTV---KQEMSHLSQQTRIQ- 128
            ...:.|.|.   |.|.:|||..| .:..|.:|........||...|:   :|:    |||:.|.
Zfish   117 QQDVKSSSNREDLHSGTALHHRPSHLGAHQSHQSAWGGTTASHISTITGGQQQ----SQQSLIYS 177

  Fly   129 -------QGMASPHAAWHAPHAGHYAPTGGSP-LQYHHAMNGMLHHPAHAVAAAHHQSVAPLHHT 185
                   .||.:|..:  ..|.|  ...|.|| :.:||      ||  |     |||...|.||.
Zfish   178 QPGGFTVNGMLNPPGS--LVHPG--LMRGESPEMDHHH------HH--H-----HHQQQHPHHHH 225

  Fly   186 LRGESPQLHIHHHMGGGDRDAISGGEEDTPTSDDLEAFAKQFKQRRIKLGFTQADVGLALGTLYG 250
                    |..||.|....|  |..:||||||||||.||||||||||||||||||||||||||||
Zfish   226 --------HHQHHAGVNSHD--SHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYG 280

  Fly   251 NVFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEADSTTGSPTSIDKIAAQGRKRKKRTSIEVSV 315
            ||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||
Zfish   281 NVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSTTGSPTSIDKIAAQGRKRKKRTSIEVSV 345

  Fly   316 KGALEQHFHKQPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPNTLGGDMMDGMPPGH 380
            |||||.||.|.|||||||||||||:|||||||||||||||||||||||||         |:|.
Zfish   346 KGALESHFLKCPKPSAQEITSLADNLQLEKEVVRVWFCNRRQKEKRMTPP---------GVPQ-- 399

  Fly   381 MHHGGYHPHHDMHGSPMGTHSHSHSPPMLSPQNMQSSAVAAHQLAAHXQSEIQESNSAAAAST 443
                          :|...::|:.:          .|.|..:...|. :.|...:::...||:
Zfish   400 --------------TPEDVYTHAGN----------GSFVVDYLKGASLKDEPDSNHNVTTASS 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vvl	NP_001303384.1	POU	212..286	CDD:197673	71/73 (97%)
vvl	NP_001303384.1	Homeobox	307..360	CDD:278475	48/52 (92%)
pou3f3a	NP_571225.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..43
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	102..172		21/73 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	186..248		30/88 (34%)
		POU	242..316	CDD:197673	71/73 (97%)
		Homeobox	337..390	CDD:278475	48/52 (92%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592248
Domainoid	1	1.000	139	1.000	Domainoid score	I4736
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	324	1.000	Inparanoid score	I2470
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D328823at33208
OrthoFinder	1	1.000	-	-		FOG0000890
OrthoInspector	1	1.000	-	-		otm24456
orthoMCL	1	0.900	-	-		OOG6_106207
Panther	1	1.100	-	-	O	PTHR11636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X514
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.760