DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vvl and Pou3f4

DIOPT Version :9

Sequence 1:	NP_001303384.1	Gene:	vvl / 38752	FlyBaseID:	FBgn0086680	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_058948.1	Gene:	Pou3f4 / 29589	RGDID:	61947	Length:	361	Species:	Rattus norvegicus

Alignment Length:	395	Identity:	198/395 - (50%)
Similarity:	214/395 - (54%)	Gaps:	91/395 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 HAAAAAAAHHQLPSSPSPNGQ------------GNGGGLGLGSGSGLGSWSALHPD--PWMQTHH 97
            ||.:|....    .||..|.|            .||..||       ..|.....|  ||..|..
  Rat    19 HADSAGMQQ----GSPFRNPQKLLQSDYLQGVPSNGHPLG-------HHWVTSLSDGGPWSSTLA 72

  Fly    98 THHLPAAAAVASAADTVKQEMSHLSQQTRIQQGMASPHAAWHAPHAGHYAPTGGSPL-------- 154
            |..|..........|.....:.|          ..|||.|.|:||..|....|.||.
  Rat    73 TSPLDQQDVKPGREDLQLGAIIH----------HRSPHVAHHSPHTNHPNAWGASPAPNSSITSS 127

  Fly   155 --------QYHHAMNGMLHH----PAHAVAAAHHQSVAPLHHTLRGESP---QLHIHHHMGGGDR 204
                    |....::|||.|    |..|.|     |...||..|| |.|   :|..||.....|
  Rat   128 GQPLNVYSQPGFTVSGMLEHGGLTPPPAAA-----STQSLHPVLR-EPPDHGELGSHHCQDHSD- 185

  Fly   205 DAISGGEEDTPTSDDLEAFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFK 269
                   |:|||||:||.|||||||||||||||||||||||||||||||||||||||||||||||
  Rat   186 -------EETPTSDELEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFK 243

  Fly   270 NMCKLKPLLQKWLEEADSTTGSPTSIDKIAAQGRKRKKRTSIEVSVKGALEQHFHKQPKPSAQEI 334
            |||||||||.||||||||:|||||||||||||||||||||||||||||.||.||.|.|||:||||
  Rat   244 NMCKLKPLLNKWLEEADSSTGSPTSIDKIAAQGRKRKKRTSIEVSVKGVLETHFLKCPKPAAQEI 308

  Fly   335 TSLADSLQLEKEVVRVWFCNRRQKEKRMTPPNTLGGDMMDGMPPGHMHHGGYHPHHDMHGSPMGT 399
            :||||||||||||||||||||||||||||||                  |...| |:::...:.|
  Rat   309 SSLADSLQLEKEVVRVWFCNRRQKEKRMTPP------------------GDQQP-HEVYSHTVKT 354

  Fly   400 HSHSH 404
            .:..|
  Rat   355 DASCH 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vvl	NP_001303384.1	POU	212..286	CDD:197673	69/73 (95%)
vvl	NP_001303384.1	Homeobox	307..360	CDD:278475	46/52 (88%)
Pou3f4	NP_058948.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	99..131		10/31 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..192		21/61 (34%)
		POU	186..260	CDD:197673	69/73 (95%)
		Homeobox	281..335	CDD:395001	47/53 (89%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	334..361		11/45 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350543
Domainoid	1	1.000	139	1.000	Domainoid score	I4657
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	325	1.000	Inparanoid score	I2400
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D328823at33208
OrthoFinder	1	1.000	-	-		FOG0000890
OrthoInspector	1	1.000	-	-		otm45409
orthoMCL	1	0.900	-	-		OOG6_106207
Panther	1	1.100	-	-	O	PTHR11636
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X514
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.760