DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vvl and Pou3f1

DIOPT Version :9

Sequence 1:	NP_001303384.1	Gene:	vvl / 38752	FlyBaseID:	FBgn0086680	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_620193.1	Gene:	Pou3f1 / 192110	RGDID:	619767	Length:	451	Species:	Rattus norvegicus

Alignment Length:	435	Identity:	204/435 - (46%)
Similarity:	222/435 - (51%)	Gaps:	135/435 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SGDLDMALGGGGYHTSSPRSAADAGEMKYMQHHHHHHAAAAAA----AHHQLPS-SPSPNGQG-- 68
            :|..|...||||:|..             :.|....||.||.|    |||..|: ||||...|
  Rat   100 TGRADDGGGGGGFHAR-------------LVHQGAAHAGAAWAQGGTAHHLGPAMSPSPGAGGGH 151

  Fly    69 --------------NGGGLGL-------GSGSGLGSWSALHPDPWMQTHHTHHLPAAAAVASAAD 112
                          .|||.||       |.|:|.|...|||.|
  Rat   152 QPQPLGLYAQAAYPGGGGGGLAGMLAAGGGGAGPGLHHALHED---------------------- 194

  Fly   113 TVKQEMSHLSQQTRIQQGMASPHAAWHAPHAGHYAPTGGSPLQYHHAMNGMLHHPAHAVAAAHHQ 177
                  .|.:|    .:....||...|. ||..:|..||                .||.||
  Rat   195 ------GHEAQ----LEPSPPPHLGAHG-HAHGHAHAGG----------------LHAAAA---- 228

  Fly   178 SVAPLHHTLRGESPQLHIHHHMGGGDRDAISGGEEDTPTSDDLEAFAKQFKQRRIKLGFTQADVG 242
                            |:|...|||........:||.|:|||||.||||||||||||||||||||
  Rat   229 ----------------HLHPGAGGGGSSVGEHSDEDAPSSDDLEQFAKQFKQRRIKLGFTQADVG 277

  Fly   243 LALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEADSTTGSPTSIDKIAAQGRKRKK 307
            ||||||||||||||||||||||||||||||||||||.|||||.||::||||::||||||||||||
  Rat   278 LALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEETDSSSGSPTNLDKIAAQGRKRKK 342

  Fly   308 RTSIEVSVKGALEQHFHKQPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPNTLGGDM 372
            ||||||.||||||.||.|.|||||.|||.||||||||||||||||||||||||||||....|...
  Rat   343 RTSIEVGVKGALESHFLKCPKPSAHEITGLADSLQLEKEVVRVWFCNRRQKEKRMTPAAGAGHPP 407

  Fly   373 MDGM----------------------PPGHMHHGGYHPHHDMHGS 395
            ||.:                      ||..:||   |.||.:.||
  Rat   408 MDDVYAPGELGPGGGGASPPSAPPPPPPAALHH---HHHHTLPGS 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vvl	NP_001303384.1	POU	212..286	CDD:197673	69/73 (95%)
vvl	NP_001303384.1	Homeobox	307..360	CDD:278475	46/52 (88%)
Pou3f1	NP_620193.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	69..114		6/13 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	134..154		9/19 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	186..253		27/135 (20%)
		POU	247..321	CDD:197673	69/73 (95%)
		Homeobox	342..396	CDD:395001	47/53 (89%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	395..451		17/58 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	139	1.000	Domainoid score	I4657
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D328823at33208
OrthoFinder	1	1.000	-	-		FOG0000890
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11636
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X514
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.020