DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vvl and Pou3f3

DIOPT Version :9

Sequence 1:	NP_001303384.1	Gene:	vvl / 38752	FlyBaseID:	FBgn0086680	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_620192.2	Gene:	Pou3f3 / 192109	RGDID:	619768	Length:	497	Species:	Rattus norvegicus

Alignment Length:	470	Identity:	227/470 - (48%)
Similarity:	248/470 - (52%)	Gaps:	128/470 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GGGGYHTSSPRSAA--------DAGEMK-----------------YMQHHHHH------HAAAAA 52
            ||||   ..|.|||        |...:|                 :|..|.|.      ||||||
  Rat    46 GGGG---MQPGSAAVTSGAYRGDPSSVKMVQSDFMQGAMAASNGGHMLSHAHQWVTALPHAAAAA 107

  Fly    53 AA----------------------HHQLPSSPSPNGQGNG--GGLG---LGSGSGLGSWSALHPD 90
            ||                      ..|.|..|.|..||..  ||.|   |.:|:.|......|..
  Rat   108 AAAAAAAVEASSPWSGSAVGMAGSPQQPPQPPPPPPQGPDVKGGAGREDLHAGTALHHRGPPHLG 172

  Fly    91 PWMQTHHTHHLP---AAAAVASAADTVKQEMSHLSQQTRIQQGMASPHAAWHAPHAGHYAPTGGS 152
            |.....|..| |   .|||.|:||.......:||......||         ..|.:..|:..||
  Rat   173 PPPPPPHQGH-PGGWGAAAAAAAAAAAAAAAAHLPSMAGGQQ---------PPPQSLLYSQPGG- 226

  Fly   153 PLQYHHAMNGMLHHP-----AHAVAAAHHQSVAPLHHTL-RGESPQL---------HIH------ 196
                 ..:||||..|     ....|....||:  :|..| ||::|:|         |.|
  Rat   227 -----FTVNGMLSAPPGPGGGGGGAGGGAQSL--VHPGLVRGDTPELAEHHHHHHHHAHPHPPHP 284

  Fly   197 -------HHMGGGDRDAISG----GEEDTPTSDDLEAFAKQFKQRRIKLGFTQADVGLALGTLYG 250
                   ||.|||....::.    .:||||||||||.||||||||||||||||||||||||||||
  Rat   285 HHAQGPPHHGGGGAGPGLNSHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYG 349

  Fly   251 NVFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEADSTTGSPTSIDKIAAQGRKRKKRTSIEVSV 315
            ||||||||||||||||||||||||||||.||||||||:|||||||||||||||||||||||||||
  Rat   350 NVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSTGSPTSIDKIAAQGRKRKKRTSIEVSV 414

  Fly   316 KGALEQHFHKQPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPP-----------NTLG 369
            |||||.||.|.|||||||||:|||||||||||||||||||||||||||||           :.:|
  Rat   415 KGALESHFLKCPKPSAQEITNLADSLQLEKEVVRVWFCNRRQKEKRMTPPGIQQQTPDDVYSQVG 479

  Fly   370 GDMMDGMPPGHMHHG 384
            ....|..||   |||
  Rat   480 TVSADTPPP---HHG 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vvl	NP_001303384.1	POU	212..286	CDD:197673	71/73 (97%)
vvl	NP_001303384.1	Homeobox	307..360	CDD:278475	48/52 (92%)
Pou3f3	NP_620192.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..62		8/18 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..189		17/68 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..316		25/87 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	458..497		14/37 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	139	1.000	Domainoid score	I4657
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	325	1.000	Inparanoid score	I2400
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D328823at33208
OrthoFinder	1	1.000	-	-		FOG0000890
OrthoInspector	1	1.000	-	-		otm45409
orthoMCL	1	0.900	-	-		OOG6_106207
Panther	1	1.100	-	-	O	PTHR11636
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X514
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.970