DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vvl and Pou3f2

DIOPT Version :9

Sequence 1:	NP_001303384.1	Gene:	vvl / 38752	FlyBaseID:	FBgn0086680	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_032925.1	Gene:	Pou3f2 / 18992	MGIID:	101895	Length:	445	Species:	Mus musculus

Alignment Length:	459	Identity:	224/459 - (48%)
Similarity:	244/459 - (53%)	Gaps:	103/459 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AATSYMTPPSGDLDMALGGGGYHTSSPRSAADAGEMKYMQHH-HHHHAAAAAAAHHQLPSSPSPN 65
            |:..:..||.|   |..|.|||..:......|.|.::...|. .|.|....|.:|    ......
Mouse    16 ASIVHAEPPGG---MQQGAGGYREAQSLVQGDYGALQSNGHPLSHAHQWITALSH----GGGGGG 73

  Fly    66 GQGNGGGLGLGSGSGLGS-WSA----------------------LHPDPWMQTHHTHHLPAAAAV 107
            |.|.|||.|.|.|.|.|| ||.                      ||....:|..|...
Mouse    74 GGGGGGGGGGGGGGGDGSPWSTSPLGQPDIKPSVVVQQGGRGDELHGPGALQQQHQQQ------- 131

  Fly   108 ASAADTVKQEMSHLSQQTRIQQGMASPHAAWHAPH-------------AGHYAPTGGSP---LQY 156
                ...:|:.....||.:.||....||...||.:             |.|..|:.|:.   |.|
Mouse   132 ----QQQQQQQQQQQQQQQQQQQQRPPHLVHHAANHHPGPGAWRSAAAAAHLPPSMGASNGGLLY 192

  Fly   157 HH---AMNGM---------LHHPAHAVAAAHHQSVAPLHHTLRGESPQLHIHHHM---------- 199
            ..   .:|||         |||  |.:..||.:.....||      |..|.|.|.
Mouse   193 SQPSFTVNGMLGAGGQPAGLHH--HGLRDAHDEPHHADHH------PHPHSHPHQQPPPPPPPQG 249

  Fly   200 ----GGGDRDAISGGEEDTPTSDDLEAFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICR 260
                .|...|..|  :||||||||||.||||||||||||||||||||||||||||||||||||||
Mouse   250 PPGHPGAHHDPHS--DEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICR 312

  Fly   261 FEALQLSFKNMCKLKPLLQKWLEEADSTTGSPTSIDKIAAQGRKRKKRTSIEVSVKGALEQHFHK 325
            ||||||||||||||||||.||||||||::|||||||||||||||||||||||||||||||.||.|
Mouse   313 FEALQLSFKNMCKLKPLLNKWLEEADSSSGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLK 377

  Fly   326 QPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPP-NTLGG--DMMDG---MPPGHMHHG 384
            .||||||||||||||||||||||||||||||||||||||| .||.|  |:..|   .||   |||
Mouse   378 CPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGGTLPGAEDVYGGSRDTPP---HHG 439

  Fly   385 GYHP 388
            ...|
Mouse   440 VQTP 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vvl	NP_001303384.1	POU	212..286	CDD:197673	71/73 (97%)
vvl	NP_001303384.1	Homeobox	307..360	CDD:278475	49/52 (94%)
Pou3f2	NP_032925.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	64..173		28/123 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..269		19/75 (25%)
		POU	264..338	CDD:197673	71/73 (97%)
		Homeobox	359..413	CDD:395001	50/53 (94%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	411..445		18/36 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	139	1.000	Domainoid score	I4762
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	329	1.000	Inparanoid score	I2431
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D328823at33208
OrthoFinder	1	1.000	-	-		FOG0000890
OrthoInspector	1	1.000	-	-		otm43337
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11636
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3844
SonicParanoid	1	1.000	-	-		X514
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.960