DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vvl and Pou2f3

DIOPT Version :9

Sequence 1:	NP_001303384.1	Gene:	vvl / 38752	FlyBaseID:	FBgn0086680	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_035269.2	Gene:	Pou2f3 / 18988	MGIID:	102565	Length:	431	Species:	Mus musculus

Alignment Length:	400	Identity:	153/400 - (38%)
Similarity:	198/400 - (49%)	Gaps:	96/400 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 DTVKQEMS----HLSQQTRIQQG------MASPH-------AAWHAPHAGHY----APTGGSPLQ 155
            |:::|.:|    ||||...:..|      |||.|       ...|......:    .|.|...||
Mouse    52 DSLQQTLSHRPCHLSQGPTMMPGNQMSGDMASLHPLQQLVLVPGHLQSVSQFLLSQTPPGQQGLQ 116

  Fly   156 YHHAMNGMLHHPAHAVAAAHHQSVAPLHHT-------------LRGES--PQLHIHHHMGGGDRD 205
                 ..:|..|       ..||...|..|             |.|.|  |.|....|:.|....
Mouse   117 -----PNLLSFP-------QQQSTLLLPQTGPGLASQAVGRPGLSGSSLEPHLDAPQHLPGPKHL 169

  Fly   206 AISGGEEDTPTSDDLEAFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKN 270
            ...||.::....::||.|||.||||||||||||.|||||:|.||||.||||||.|||||.|||||
Mouse   170 PGPGGNDEPTDLEELEKFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKN 234

  Fly   271 MCKLKPLLQKWLEEADS-----TTGSPTSIDKIA-AQGRKRKKRTSIEVSVKGALEQHFHKQPKP 329
            ||||||||:|||.:|:|     :..:|:|...:: ..|||||||||||.:::..||:.|...|||
Mouse   235 MCKLKPLLEKWLNDAESSPSDPSASTPSSYPTLSEVFGRKRKKRTSIETNIRLTLEKRFQDNPKP 299

  Fly   330 SAQEITSLADSLQLEKEVVRVWFCNRRQKEKR------------------MTPPNTLGGDMMDGM 376
            |::||:.:|:.|.:||||||||||||||||||                  ::|..:||   ...:
Mouse   300 SSEEISMIAEQLSMEKEVVRVWFCNRRQKEKRINCPVATPVKPPIYNSRLVSPSGSLG---PLSV 361

  Fly   377 PPGHMHHGGYHPHHDMHGSPMGTHSHSHSPPMLSPQNMQSSAVAAHQLAAHXQSEIQESNSAAA- 440
            ||             :|.:..||.:.|.||...|..:...|.:.|....|      .::||.||
Mouse   362 PP-------------VHSTMPGTVTSSCSPGNNSRPSSPGSGLHASSPTA------SQNNSKAAM 407

  Fly   441 -ASTPASLNS 449
             :|:.:|.||
Mouse   408 NSSSSSSFNS 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vvl	NP_001303384.1	POU	212..286	CDD:197673	54/73 (74%)
vvl	NP_001303384.1	Homeobox	307..360	CDD:278475	32/52 (62%)
Pou2f3	NP_035269.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	130..180		11/49 (22%)
		POU	176..250	CDD:197673	54/73 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	247..275		6/27 (22%)
		Homeobox	277..330	CDD:278475	32/52 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	352..419		22/87 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810