DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vvl and Pou2f1

DIOPT Version :9

Sequence 1:	NP_001303384.1	Gene:	vvl / 38752	FlyBaseID:	FBgn0086680	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_001094109.1	Gene:	Pou2f1 / 171068	RGDID:	621689	Length:	768	Species:	Rattus norvegicus

Alignment Length:	742	Identity:	211/742 - (28%)
Similarity:	292/742 - (39%)	Gaps:	252/742 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 MQTHHT--HHLPAAAAVASAADTVK---------------QEMSHLSQQTRIQQGMASPHAAWHA 140
            :|.|..  .|..|.|.::::|.|..               |::..|.||....|.....|..
  Rat   160 VQQHSASQQHSAAGATISASAATPMTQIPLSQPIQIAQDLQQLQQLQQQNLNLQQFVLVHPT--- 221

  Fly   141 PHAGHYAPTGGSPLQY-----HHAMNGMLH------------------------------HPAHA 170
                    |...|.|:     .....|:|.                              .|...
  Rat   222 --------TNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQQSQANLLQPQPSITLTSQPTTPTRT 278

  Fly   171 VAAAHHQSVAPLHHTL--RGESPQLHIHHHMGGGDRDAISGGEEDTPTSDDLEAFAKQFKQRRIK 233
            :||...|:: |...|.  |.::|.|                  |:....::||.|||.|||||||
  Rat   279 IAATPIQTL-PQSQTTPKRIDTPSL------------------EEPSDLEELEQFAKTFKQRRIK 324

  Fly   234 LGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEA-----DSTTGSPT 293
            |||||.|||||:|.||||.||||||.|||||.|||||||||||||:|||.:|     |||..||:
  Rat   325 LGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDSTASSPS 389

  Fly   294 SIDK--IAAQG--RKRKKRTSIEVSVKGALEQHFHKQPKPSAQEITSLADSLQLEKEVVRVWFCN 354
            :::.  :.|:|  |:||||||||.:::.|||:.|.:..||::::||.:|:.|.:||||:||||||
  Rat   390 ALNSPGLGAEGLNRRRKKRTSIETNIRVALEKSFMENQKPTSEDITLIAEQLNMEKEVIRVWFCN 454

  Fly   355 RRQKEKRMTPPNTLGGDMMDGMPPGHMHHGGYHPHHDMHGSPMGTHSHSHSPPMLSPQN------ 413
            |||||||:.||:: ||....             |...:..||  |...:.:|.:::...
  Rat   455 RRQKEKRINPPSS-GGTSSS-------------PIKAIFPSP--TSLVATTPSLVTSSTATTLTV 503

  Fly   414 ---MQSSAVAAHQLAAHXQSEIQESNSAAAAST--PAS----LNSLSQQQQQQQQQQQQQHQQQQ 469
               :..::.|...|:.. .::...:|:|...||  |||    ..|||.
  Rat   504 NPVLPLTSAAMTNLSLTGTTDSTSNNTATVISTAPPASSAVTSPSLSP----------------- 551

  Fly   470 QHQQQQHTPNTPSSSA----GSSATMTSQVMSPQSPLGSSSAGNQANNNNNNNNNNNSSTNNNNN 530
                      :||:||    .|||:.||...:..:||.|....:|.....:......::.
  Rat   552 ----------SPSASASTSEASSASETSTTQTTSTPLPSPLGASQVMVTASGLQTAAAAA----- 601

  Fly   531 NNNNEEQVKHHQQQQQQQQASSIAAAAAAAMYMDPMRYQHPHHPHPHPHQHPHLNPA-HHPHLFH 594
                      .|...|....:|:||.||||                      .|||. ..|..|.
  Rat   602 ----------LQGAAQLPANASLAAMAAAA----------------------GLNPGLMAPSQFA 634

  Fly   595 TSDQLQHSQQQTVGGTSSNSQLSPGAGSNSGL-PLQPPSSA----------------SPAGSASS 642
            ....|......|:||.     |||...|||.| .:|..:|:                :.||.|.:
  Rat   635 AGGALLSLNPGTLGGA-----LSPALMSNSTLATIQALASSGSLPITSLDATGNLVFANAGGAPN 694

  Fly   643 VLGGHLNLNPLHQHHHYQHHHHQQHHHHQQQQQQLHARRLFELSLQFGAAA-----APGAVRHFN 702
            ::...|.|||                      |.|.......:||...|||     ||.|..|.:
  Rat   695 IVTAPLFLNP----------------------QNLSLLTSNPVSLVSAAAASTGNSAPTASLHAS 737

  Fly   703 S----------FGGAGGAGGEXHSSAA 719
            |          |..|..:|.. .::||
  Rat   738 STSTESIQNSLFTVASASGAASTTTAA 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vvl	NP_001303384.1	POU	212..286	CDD:197673	56/78 (72%)
vvl	NP_001303384.1	Homeobox	307..360	CDD:278475	30/52 (58%)
Pou2f1	NP_001094109.1	POU	303..377	CDD:197673	55/73 (75%)
Pou2f1	NP_001094109.1	Homeobox	407..460	CDD:278475	30/52 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810