DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vvl and Pou2f2

DIOPT Version :9

Sequence 1:	NP_001303384.1	Gene:	vvl / 38752	FlyBaseID:	FBgn0086680	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	XP_038968890.1	Gene:	Pou2f2 / 117058	RGDID:	621690	Length:	825	Species:	Rattus norvegicus

Alignment Length:	734	Identity:	208/734 - (28%)
Similarity:	274/734 - (37%)	Gaps:	210/734 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 AAAAAAAH-----HQLPSSPSPNGQGNGGGLGLGSGSGLGSWSALHP-DPWMQTHHTHHLPAAAA 106
            |||||||.     ....||.|.....:|||             .|.| .|..|...|..|..:..
  Rat   159 AAAAAAASTSSSTSSASSSTSQTPASSGGG-------------DLPPSQPTSQPPGTPQLTLSQP 210

  Fly   107 VASAADTVKQEMS----------HLS--------QQTRIQQGMASPHAAWHAPHAGHYA-----P 148
            :...|..::|.:.          ||.        |..:.|.|:......:..|.....|     |
  Rat   211 IQLTAQDIQQLLQLQQLVLVPGHHLQPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQP 275

  Fly   149 TGGSPLQYHHAMNGMLHHPAHAVAAAHHQSVAPLHHTLRGESPQLHIHHHMGGGDRDAISGGEED 213
            ..|.|.|.|..       |...:.:    :..|.....|...|..|:.|.......:..|..||.
  Rat   276 RAGLPTQLHPG-------PRSCIPS----TCPPYQAMTRPTLPDPHLSHPQPSKCLEPPSHPEEP 329

  Fly   214 TPTSDDLEAFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLL 278
            :.. ::||.||:.||||||||||||.|||||:|.||||.||||||.|||||.|||||||||||||
  Rat   330 SDL-EELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLL 393

  Fly   279 QKWLEEA-----DSTTGSPTSIDKIA-----AQGRKRKKRTSIEVSVKGALEQHFHKQPKPSAQE 333
            :|||.:|     ||:..||..:...:     ..||:||||||||.:|:.|||:.|....||:::|
  Rat   394 EKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKKRTSIETNVRFALEKSFLANQKPTSEE 458

  Fly   334 ITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPNTLGGDMMDGMPPGHMHHGGYHPHHDMHGSPMG 398
            |..:|:.|.:||||:|||||||||||||:.|.:..                   |.....|.|.
  Rat   459 ILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCSAA-------------------PMLPSPGKPT- 503

  Fly   399 THSHSHSPPMLSPQNMQSSAVAAHQLAAHXQSEIQESNSAAAASTPA--------------SLNS 449
                |:||.:::||. .:..:...|.::. .:.:...:||.....|:              .|||
  Rat   504 ----SYSPHLVTPQG-GAGTLPLSQASSSLSTTVTTLSSAVGTLHPSRTAGGGGGGGGAAPPLNS 563

  Fly   450 LSQQQQQQQQQQQQQHQQQQQHQQQQHTPNTPSSSAGSSATMTSQVMSPQ---SPLGSSSAGNQA 511
            :                              ||.:....||..|...|||   |.:|.:.....|
  Rat   564 I------------------------------PSVTPPPPATTNSTNPSPQGSHSAIGLTGLNPSA 598

  Fly   512 NNNNNNNNNNNSSTNNNNNNNNNEEQVKHHQQQQQQQQASSIAAAAAAAMYMDPMRYQHPHHPHP 576
            .:.....::..|.....||                     .:|....|...|.           |
  Rat   599 GSTMVGLSSGLSPALMGNN---------------------PLATIQGACCLMS-----------P 631

  Fly   577 HPHQH-PHLNPAHHPHLFHTSDQLQHSQQQTVGGTSSNSQLSPGAGSNSGLPLQP--PSSASPAG 638
            |.||. |.|                        |..:.|.|.|       .|..|  |.:|..|.
  Rat   632 HCHQSCPLL------------------------GLEAPSPLLP-------QPCHPALPLTALLAC 665

  Fly   639 SASSVLGGHLNLNPLHQHHHYQHHHHQQHHHHQQQQQQLHARRLFELSLQFGA-AAAPGAVRHFN 702
            |:.||.|..:.:..|......|........|   :.|.|......:|||.|.: |.|.|......
  Rat   666 SSPSVFGEGVRVLLLGSQWDRQEMGCSGRVH---RGQGLPGLMYLQLSLSFSSPALASGGTLPLT 727

  Fly   703 SFGGAG----GAGGEXHSS 717
            |...:|    ||.|. ..|
  Rat   728 SLDSSGNLVLGAAGAAPGS 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vvl	NP_001303384.1	POU	212..286	CDD:197673	55/78 (71%)
vvl	NP_001303384.1	Homeobox	307..360	CDD:278475	31/52 (60%)
Pou2f2	XP_038968890.1	PRK10263	<231..>348	CDD:236669	30/128 (23%)
		POU	327..401	CDD:197673	55/74 (74%)
		Homeobox	432..486	CDD:395001	32/53 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350541
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840