DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vvl and Pou2f3

DIOPT Version :9

Sequence 1:	NP_001303384.1	Gene:	vvl / 38752	FlyBaseID:	FBgn0086680	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_001099215.1	Gene:	Pou2f3 / 116544	RGDID:	621691	Length:	430	Species:	Rattus norvegicus

Alignment Length:	395	Identity:	151/395 - (38%)
Similarity:	193/395 - (48%)	Gaps:	95/395 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 DTVKQEMS----HLSQQTRIQQG------MASPH-------AAWHAPHAGHY----APTGGSPLQ 155
            ||::|.:|    ||||...:..|      |||.|       ...|......:    .|.|...||
  Rat    52 DTLQQSLSHRPCHLSQGPTMMPGNQMSGDMASLHPLQQLVLVPGHLQSVSQFLLSQTPPGQQGLQ 116

  Fly   156 YHHAMNGMLHHPAHAVAAAHHQSVAPLHHT-------------LRGES--PQLHIHHHMGGGDRD 205
                 ..:|..|       ..||...|..|             |.|.|  |.|....|:.|....
  Rat   117 -----PNLLSFP-------QQQSTLLLPQTGPGLTSQAVGRPGLSGSSLEPHLEASQHLPGPKHL 169

  Fly   206 AISGGEEDTPTSDDLEAFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKN 270
            ...||.::....::||.|||.||||||||||||.|||||:|.||||.||||||.|||||.|||||
  Rat   170 PGPGGNDEPTDLEELEKFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKN 234

  Fly   271 MCKLKPLLQKWLEEADS-----TTGSPTSIDKIA-AQGRKRKKRTSIEVSVKGALEQHFHKQPKP 329
            ||||||||:|||.:|:|     :..:|:|...:: ..|||||||||||.:::..||:.|...|||
  Rat   235 MCKLKPLLEKWLNDAESSPSDPSASTPSSYPTLSEVFGRKRKKRTSIETNIRLTLEKRFQDNPKP 299

  Fly   330 SAQEITSLADSLQLEKEVVRVWFCNRRQKEKR------------------MTPPNTLGGDMMDGM 376
            |::||:.:|:.|.:||||||||||||||||||                  ::|..:||.   ..:
  Rat   300 SSEEISMIAEQLSMEKEVVRVWFCNRRQKEKRINCPVATPVKPPIYNSRLVSPSGSLGS---LSV 361

  Fly   377 PPGHMHHGGYHPHHDMHGSPMGTHSHSHSPPMLSPQNMQSSAVAAHQLAAHXQSEIQESNSAAAA 441
            ||             :|.:..||.:.|.||...|..:...|.:       | .|.....|::.||
  Rat   362 PP-------------VHSTMPGTVTSSCSPGNNSRPSSPGSGL-------HASSPTASQNNSKAA 406

  Fly   442 STPAS 446
            ..|:|
  Rat   407 MNPSS 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vvl	NP_001303384.1	POU	212..286	CDD:197673	54/73 (74%)
vvl	NP_001303384.1	Homeobox	307..360	CDD:278475	32/52 (62%)
Pou2f3	NP_001099215.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	129..180		11/50 (22%)
		POU	176..250	CDD:197673	54/73 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..271		4/21 (19%)
		Homeobox	277..330	CDD:278475	32/52 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..413		19/80 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810